Molecule Details
| InChIKey | ALCVRKZFLFWUAZ-UHFFFAOYSA-N |
|---|---|
| Compound Name | 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,5-dienamide |
| Canonical SMILES | CC(=CC(C)C=CC(=O)NO)C(=O)c1ccc(N(C)C)cc1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 13 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.87 |
| Source | BindingDB |
2D Structure
Activity Profile
Target Activities (13)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| O15379 | HDAC3 | Homo sapiens | Human | PF00850 | 8.7 | IC50 | BindingDB |
| Q13547 | HDAC1 | Homo sapiens | Human | PF00850 | 8.1 | IC50 | BindingDB |
| Q969S8 | HDAC10 | Homo sapiens | Human | PF00850 | 8.1 | IC50 | BindingDB |
| Q9UQL6 | HDAC5 | Homo sapiens | Human | PF12203 PF00850 | 7.9 | IC50 | BindingDB |
| Q92769 | HDAC2 | Homo sapiens | Human | PF00850 | 7.8 | IC50 | BindingDB |
| Q9UBN7 | HDAC6 | Homo sapiens | Human | PF00850 PF02148 | 7.8 | IC50 | BindingDB |
| Q96DB2 | HDAC11 | Homo sapiens | Human | PF00850 | 7.8 | IC50 | BindingDB |
| P13726 | F3 | Homo sapiens | Human | PF09294 PF01108 | 7.6 | IC50 | BindingDB |
| Q9UKV0 | HDAC9 | Homo sapiens | Human | PF12203 PF00850 | 7.6 | IC50 | BindingDB |
| P56524 | HDAC4 | Homo sapiens | Human | PF12203 PF00850 | 7.5 | IC50 | BindingDB |
| Q8WUI4 | HDAC7 | Homo sapiens | Human | PF00850 | 7.3 | IC50 | BindingDB |
| Q9BY41 | HDAC8 | Homo sapiens | Human | PF00850 | 6.8 | IC50 | BindingDB |
| Q7K6A1 | Plasmodium falciparum (isolate 3D7) | Pathogen | PF00850 | 9.2 | IC50 | BindingDB |