Molecule Details
InChIKeyAIOFXERAXQYANK-UWVGGRQHSA-N
Compound Nametrans-(1S,3S)-3-N-(3-chloro-5-propan-2-ylpyrazolo[1,5-a]pyrimidin-7-yl)cyclopentane-1,3-diamine
Canonical SMILESCC(C)c1cc(N[C@H]2CC[C@H](N)C2)n2ncc(Cl)c2n1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)9
Pfam Stratification Cross-Family
Avg pChEMBL6.96
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (9)
Target Gene Organism Category Pfam pChEMBL Type Source
O60563 CCNT1 Homo sapiens Human PF00134 PF21797 8.4 IC50 ChEMBL
P50750 CDK9 Homo sapiens Human PF00069 8.4 IC50 ChEMBL
P11802 CDK4 Homo sapiens Human PF00069 7.2 IC50 ChEMBL
P24385 CCND1 Homo sapiens Human PF02984 PF00134 6.6 IC50 ChEMBL
P50613 CDK7 Homo sapiens Human PF00069 6.6 IC50 ChEMBL
P51946 CCNH Homo sapiens Human PF16899 PF00134 6.6 IC50 ChEMBL
P24864 CCNE1 Homo sapiens Human PF02984 PF00134 6.5 IC50 ChEMBL
Q00526 CDK3 Homo sapiens Human PF00069 6.5 IC50 ChEMBL
Q00534 CDK6 Homo sapiens Human PF00069 6.0 IC50 ChEMBL