InChIKey	AHYMHWXQRWRBKT-UHFFFAOYSA-N
Canonical SMILES	CN1CCC(COc2cnc(-c3cccc(Cn4nc(-c5cccc(C#N)c5)ccc4=O)c3)nc2)CC1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	2
Pfam Stratification	Cross-Family
Avg pChEMBL	7.29
Source	ChEMBL;BindingDB

DrugBank ID	DB15133
Drug Name	Tepotinib
CAS Number	1100598-32-0
Groups	approved investigational
ATC Codes	L01EX21
Description	Tepotinib is a MET tyrosine kinase inhibitor intended to treat a variety of MET-overexpressing solid tumors.[A228058] It was originally developed in partnership between EMD Serono and the University of Texas M.D. Anderson Cancer Center in 2009 and has since been investigated in the treatment of neur...

---

Categories: Antineoplastic Agents Antineoplastic and Immunomodulating Agents BCRP/ABCG2 Inhibitors BSEP/ABCB11 Inhibitors Cytochrome P-450 CYP2C8 Substrates Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strong) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (moderate) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Kinase Inhibitor MATE 1 Inhibitors MATE 2 Inhibitors MATE inhibitors Mesenchymal Epithelial Transition Inhibitors OCT1 inhibitors OCT2 Inhibitors P-glycoprotein inhibitors P-glycoprotein substrates Protein Kinase Inhibitors Proto-Oncogene Proteins c-met, antagonists & inhibitors Tyrosine Kinase Inhibitors

---

Cross-references: BindingDB: 50065457 CHEMBL3402762 ChemSpider: 28637823 Drugs Product Database (DPD): 23595 PDB: 3E8 RxCUI: 2477103 Wikipedia: C-Met_inhibitor ZINC: ZINC000043202335