InChIKey	AHOUBRCZNHFOSL-YOEHRIQHSA-N
Compound Name	Paroxetine
Canonical SMILES	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	13
Pfam Stratification	Cross-Family
Avg pChEMBL	7.09
Source	BindingDB;ChEMBL

DrugBank ID	DB00715
Drug Name	Paroxetine
CAS Number	61869-08-7
Groups	approved investigational
ATC Codes	N06AB05
Description	Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others.[T653] It was approved by the FDA in the early ...

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Categories: Agents producing tachycardia Anticholinergic Agents Antidepressive Agents Antidepressive Agents Indicated for Depression Antidepressive Agents, Second-Generation Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (strength unknown) Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (strength unknown) Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strong) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Drugs causing inadvertant photosensitivity Enzyme Inhibitors Hypoglycemia-Associated Agents Membrane Transport Modulators Muscarinic Antagonists Nervous System Neurotransmitter Agents Neurotransmitter Uptake Inhibitors P-glycoprotein inhibitors Photosensitizing Agents Piperidines Psychoanaleptics Psychotropic Drugs Selective Serotonin Reuptake Inhibitors Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin Agents Serotonin Modulators

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Cross-references: BindingDB: 50331515 ChEBI: 7936 CHEMBL490 ChemSpider: 39888 Drugs Product Database (DPD): 11340 C07415 D02362 PDB: 8PR PharmGKB: PA450801 PubChem:43815 PubChem:46504821 RxCUI: 32937 Therapeutic Targets Database: DAP001428 Wikipedia: Paroxetine ZINC: ZINC000000527386