Molecule Details
InChIKeyAGYRJOAGMDIFKL-UHFFFAOYSA-N
Compound Name1-[4-(3-methyl-2H-indazol-4-yl)phenyl]-3-[3-(trifluoromethyl)phenyl]urea
Canonical SMILESCc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)c12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)17
Pfam Stratification Cross-Family
Avg pChEMBL6.79
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (17)
Target Gene Organism Category Pfam pChEMBL Type Source
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 8.3 Ki ChEMBL
Q8NE63 HIPK4 Homo sapiens Human PF00069 7.8 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 7.7 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 7.7 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 7.5 Ki ChEMBL
P30530 AXL Homo sapiens Human PF00041 PF13927 PF07714 7.2 Ki ChEMBL
P04629 NTRK1 Homo sapiens Human PF13855 PF16920 PF07714 PF18613 6.7 Ki ChEMBL
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.7 Ki ChEMBL
Q16620 NTRK2 Homo sapiens Human PF07679 PF13855 PF16920 PF01462 PF07714 6.7 Ki ChEMBL
P10721 KIT Homo sapiens Human PF00047 PF07714 6.4 Ki ChEMBL
P23443 RPS6KB1 Homo sapiens Human PF00069 PF00433 6.4 Ki ChEMBL
Q9H4B4 PLK3 Homo sapiens Human PF00069 PF00659 6.2 Ki ChEMBL
O75582 RPS6KA5 Homo sapiens Human PF00069 PF00433 6.1 Ki ChEMBL
O14920 IKBKB Homo sapiens Human PF18397 PF12179 PF00069 6.0 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 6.0 Ki ChEMBL