Molecule Details
InChIKeyAFGYODUJVVOZAX-CYFREDJKSA-N
Canonical SMILESC=CC(=O)N1CCN([C@@H](CC2CC2)c2ccc([C@H](C)Nc3ncc4c(n3)N(CC)C(=O)OC4)cc2)CC1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Homologous
Avg pChEMBL7.81
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB21642
Drug NameCrelosidenib
CAS Number2230263-60-0
Groups investigational
ATC Codes nan
DescriptionCrelosidenib is a small molecule drug. Crelosidenib is under investigation in clinical trial NCT04603001 (Study of Oral LY3410738 in Patients With Advanced Hematologic Malignancies With IDH1 or IDH2 Mutations). Crelosidenib has a monoisotopic molecular weight of 504.28 Da.

Cross-references: BindingDB: 497335 CHEMBL6000618
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
O75874 IDH1 Homo sapiens Human PF00180 8.2 IC50 ChEMBL;BindingDB
P48735 IDH2 Homo sapiens Human PF00180 7.4 IC50 ChEMBL;BindingDB