Molecule Details
InChIKeyAEUDFMRQSRTMSH-UHFFFAOYSA-N
Compound NameB-Raf IN 18
Canonical SMILESCC(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(Nc3ccc(N4CCOCC4)nc3)n2)s1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)4
Pfam Stratification Homologous
Avg pChEMBL7.55
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (4)
Target Gene Organism Category Pfam pChEMBL Type Source
Q02763 TEK Homo sapiens Human PF00041 PF10430 PF07714 8.5 Kd BindingDB
P15056 BRAF Homo sapiens Human PF00130 PF07714 PF02196 8.4 IC50 ChEMBL
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.7 Kd BindingDB
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.6 Kd BindingDB