Molecule Details
| InChIKey | AEQDJSLRWYMAQI-KRWDZBQOSA-N |
|---|---|
| Compound Name | (-)-Tetrahydropalmatine |
| Canonical SMILES | COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.83 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB12093 |
|---|---|
| Drug Name | Tetrahydropalmatine |
| CAS Number | 483-14-7 |
| Groups | investigational |
| ATC Codes | nan |
| Description | Tetrahydropalmatine is under investigation in clinical trial NCT02118610 (Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity). |
Categories: Adrenergic Agents Agents causing hyperkalemia Alkaloids Analgesics Analgesics, Non-Narcotic Antiarrhythmic agents Antihypertensive Agents Antipsychotic Agents Benzylisoquinolines Bradycardia-Causing Agents Calcium Channel Blockers Calcium-Regulating Hormones and Agents Cardiovascular Agents Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Substrates Dopamine Agents Dopamine Antagonists Dopamine D2 Receptor Antagonists Heterocyclic Compounds, Fused-Ring Membrane Transport Modulators Neurotoxic agents Neurotransmitter Agents Peripheral Nervous System Agents Potential QTc-Prolonging Agents Psychotropic Drugs QTc Prolonging Agents Sensory System Agents Tranquilizing Agents Vasodilating Agents
Cross-references: BindingDB: 50424077 ChEBI: 16563 CHEMBL487182 ChemSpider: 65252 C02890 PubChem:72301 PubChem:347828397 Wikipedia: Tetrahydropalmatine ZINC: ZINC000019535049
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P13726 | F3 | Homo sapiens | Human | PF09294 PF01108 | 7.6 | IC50 | ChEMBL;BindingDB |
| P21728 | DRD1 | Homo sapiens | Human | PF00001 | 6.8 | Ki | ChEMBL;BindingDB |
| P21918 | DRD5 | Homo sapiens | Human | PF00001 | 6.5 | Ki | ChEMBL;BindingDB |
| P14416 | DRD2 | Homo sapiens | Human | PF00001 | 6.3 | IC50 | ChEMBL;BindingDB |