Molecule Details
| InChIKey | ADZBMFGQQWPHMJ-RHSMWYFYSA-N |
|---|---|
| Compound Name | Sotuletinib |
| Canonical SMILES | CNC(=O)c1cc(Oc2ccc3nc(N[C@@H]4CCCC[C@H]4O)sc3c2)ccn1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.48 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB16838 |
|---|---|
| Drug Name | BLZ-945 |
| CAS Number | 953769-46-5 |
| Groups | investigational |
| ATC Codes | nan |
| Description | nan |
Categories: Heterocyclic Compounds, Fused-Ring Pyridines Receptor, Macrophage Colony-Stimulating Factor, antagonists & inhibitors Thiazoles
Cross-references: BindingDB: 50460035 CHEMBL4227505 ChemSpider: 29362221 ZINC: ZINC000068203100
Target Activities (3)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P07333 | CSF1R | Homo sapiens | Human | PF00047 PF25305 PF07714 | 9.0 | IC50 | ChEMBL;BindingDB |
| P09619 | PDGFRB | Homo sapiens | Human | PF00047 PF13927 PF25305 PF07714 | 6.8 | IC50 | ChEMBL;BindingDB |
| P16234 | PDGFRA | Homo sapiens | Human | PF07679 PF25305 PF07714 | 6.7 | Kd | ChEMBL;BindingDB |