Molecule Details
| InChIKey | ADEBPBSSDYVVLD-HXUWFJFHSA-N |
|---|---|
| Compound Name | (R)-donepezil |
| Canonical SMILES | COc1cc2c(cc1OC)C(=O)[C@H](CC1CCN(Cc3ccccc3)CC1)C2 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 6 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.94 |
| Source | BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB07701 |
|---|---|
| Drug Name | 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE |
| CAS Number | nan |
| Groups | experimental |
| ATC Codes | nan |
| Description | nan |
Cross-references: BindingDB: 50037187 ChEBI: 53292 CHEMBL107316 ChemSpider: 976141 PDB: E20 PubChem:1150567 PubChem:99444172 ZINC: ZINC000000897251
Target Activities (6)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q99720 | SIGMAR1 | Homo sapiens | Human | PF04622 | 7.8 | Ki | BindingDB |
| P22303 | ACHE | Homo sapiens | Human | PF08674 PF00135 | 7.8 | IC50 | BindingDB |
| P06276 | BCHE | Homo sapiens | Human | PF08674 PF00135 | 6.9 | IC50 | BindingDB |
| P56817 | BACE1 | Homo sapiens | Human | PF00026 | 6.5 | IC50 | BindingDB |
| Q9Y5N1 | HRH3 | Homo sapiens | Human | PF00001 | 6.5 | IC50 | BindingDB |
| Q12809 | KCNH2 | Homo sapiens | Human | PF00027 PF00520 PF13426 | 6.2 | IC50 | BindingDB |
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P22303 | ACHE | Acetylcholinesterase | binder | targets |