Molecule Details
| InChIKey | ABVXSVHDNRZRGD-UHFFFAOYSA-N |
|---|---|
| Compound Name | US11472805, Example 59 |
| Canonical SMILES | COc1c(F)cc(-c2c3n(c4nccnc24)CCN(C2CC2)C3=O)cc1F |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.38 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q07343 | PDE4B | Homo sapiens | Human | PF18100 PF00233 | 8.0 | IC50 | BindingDB |
| P27815 | PDE4A | Homo sapiens | Human | PF18100 PF00233 | 7.9 | IC50 | ChEMBL;BindingDB |
| Q08493 | PDE4C | Homo sapiens | Human | PF18100 PF00233 | 7.1 | IC50 | BindingDB |
| Q08499 | PDE4D | Homo sapiens | Human | PF18100 PF00233 | 6.5 | IC50 | BindingDB |