(S)-6-fluoro-3-{4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-1,2,3-triazol-1-yl}-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one

InChIKey	`AAHNBILIYONQLX-QFIPXVFZSA-N`
Compound Name	(S)-6-fluoro-3-{4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-1,2,3-triazol-1-yl}-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one
Canonical SMILES	`COc1cc(-c2cn([C@H]3CCc4c(F)cccc4N(CC(F)(F)F)C3=O)nn2)ccc1-n1cnc(C)c1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	13
Pfam Stratification	Cross-Family
Avg pChEMBL	6.86
Source	ChEMBL;BindingDB

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P31645	SLC6A4	Homo sapiens	Human	PF03491 PF00209	7.6	Ki	ChEMBL
P49768	PSEN1	Homo sapiens	Human	PF01080	7.5	IC50	ChEMBL;BindingDB
P05067	APP	Homo sapiens	Human	PF10515 PF12924 PF12925 PF02177 PF03494 PF00014	7.2	IC50	ChEMBL
P49810	PSEN2	Homo sapiens	Human	PF01080	7.2	IC50	ChEMBL
Q8WW43	APH1B	Homo sapiens	Human	PF06105	7.2	IC50	ChEMBL
Q92542	NCSTN	Homo sapiens	Human	PF18266 PF05450	7.2	IC50	ChEMBL
Q96BI3	APH1A	Homo sapiens	Human	PF06105	7.2	IC50	ChEMBL
Q9NZ42	PSENEN	Homo sapiens	Human	PF10251	7.2	IC50	ChEMBL
Q01959	SLC6A3	Homo sapiens	Human	PF00209	6.7	Ki	ChEMBL
P23975	SLC6A2	Homo sapiens	Human	PF00209	6.1	Ki	ChEMBL
Q5BJF2	TMEM97	Homo sapiens	Human	PF05241	6.0	Ki	ChEMBL
P25021	HRH2	Homo sapiens	Human	PF00001	6.0	Ki	ChEMBL
O60939	SCN2B	Homo sapiens	Human	PF07686	6.0	IC50	ChEMBL