Lipid and atherosclerosis
hsa05417 136 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
O60674 |
JAK2 | Tyrosine-protein kinase JAK2 | Homo sapiens | 10545 | Detail |
P42336 |
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 5616 | Detail |
O00329 |
PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 3772 | Detail |
P27986 |
PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | Homo sapiens | 2553 | Detail |
P49841 |
GSK3B | Glycogen synthase kinase-3 beta | Homo sapiens | 2206 | Detail |
P12931 |
SRC | Proto-oncogene tyrosine-protein kinase Src | Homo sapiens | 1978 | Detail |
P42338 |
PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 1951 | Detail |
P14780 |
MMP9 | Matrix metalloproteinase-9 | Homo sapiens | 1941 | Detail |
P01116 |
KRAS | GTPase KRas | Homo sapiens | 1811 | Detail |
Q16539 |
MAPK14 | Mitogen-activated protein kinase 14 | Homo sapiens | 1754 | Detail |
O75116 |
ROCK2 | Rho-associated protein kinase 2 | Homo sapiens | 1696 | Detail |
P31749 |
AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens | 1633 | Detail |
P03956 |
MMP1 | Interstitial collagenase | Homo sapiens | 1338 | Detail |
P08254 |
MMP3 | Stromelysin-1 | Homo sapiens | 1292 | Detail |
P04637 |
TP53 | Cellular tumor antigen p53 | Homo sapiens | 1173 | Detail |
P10415 |
BCL2 | Apoptosis regulator Bcl-2 | Homo sapiens | 1065 | Detail |
Q07817 |
BCL2L1 | Bcl-2-like protein 1 | Homo sapiens | 990 | Detail |
P01111 |
NRAS | GTPase NRas | Homo sapiens | 923 | Detail |
P28482 |
MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens | 906 | Detail |
P31751 |
AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens | 896 | Detail |
P45983 |
MAPK8 | Mitogen-activated protein kinase 8 | Homo sapiens | 748 | Detail |
P19793 |
RXRA | Retinoic acid receptor RXR-alpha | Homo sapiens | 702 | Detail |
P17252 |
PRKCA | Protein kinase C alpha type | Homo sapiens | 679 | Detail |
P45984 |
MAPK9 | Mitogen-activated protein kinase 9 | Homo sapiens | 676 | Detail |
P07900 |
HSP90AA1 | Heat shock protein HSP 90-alpha | Homo sapiens | 674 | Detail |
Q9UHD2 |
TBK1 | Serine/threonine-protein kinase TBK1 | Homo sapiens | 639 | Detail |
P53779 |
MAPK10 | Mitogen-activated protein kinase 10 | Homo sapiens | 625 | Detail |
P53778 |
MAPK12 | Mitogen-activated protein kinase 12 | Homo sapiens | 606 | Detail |
P08238 |
HSP90AB1 | Heat shock protein HSP 90-beta | Homo sapiens | 602 | Detail |
Q14164 |
IKBKE | Inhibitor of nuclear factor kappa-B kinase subunit epsilon | Homo sapiens | 596 | Detail |
Q15759 |
MAPK11 | Mitogen-activated protein kinase 11 | Homo sapiens | 594 | Detail |
Q16236 |
NFE2L2 | Nuclear factor erythroid 2-related factor 2 | Homo sapiens | 557 | Detail |
O15264 |
MAPK13 | Mitogen-activated protein kinase 13 | Homo sapiens | 533 | Detail |
O00459 |
PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | Homo sapiens | 485 | Detail |
P07948 |
LYN | Tyrosine-protein kinase Lyn | Homo sapiens | 474 | Detail |
P05362 |
ICAM1 | Intercellular adhesion molecule 1 | Homo sapiens | 462 | Detail |
P42574 |
CASP3 | Caspase-3 | Homo sapiens | 444 | Detail |
Q9NWZ3 |
IRAK4 | Interleukin-1 receptor-associated kinase 4 | Homo sapiens | 431 | Detail |
P37231 |
PPARG | Peroxisome proliferator-activated receptor gamma | Homo sapiens | 417 | Detail |
O14920 |
IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | Homo sapiens | 411 | Detail |
P11712 |
CYP2C9 | Cytochrome P450 2C9 | Homo sapiens | 408 | Detail |
Q05397 |
PTK2 | Focal adhesion kinase 1 | Homo sapiens | 325 | Detail |
Q9Y243 |
AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens | 321 | Detail |
P51617 |
IRAK1 | Interleukin-1 receptor-associated kinase 1 | Homo sapiens | 312 | Detail |
P04798 |
CYP1A1 | Cytochrome P450 1A1 | Homo sapiens | 311 | Detail |
P55210 |
CASP7 | Caspase-7 | Homo sapiens | 306 | Detail |
Q92569 |
PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | Homo sapiens | 289 | Detail |
P27361 |
MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens | 234 | Detail |
O15530 |
PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | Homo sapiens | 228 | Detail |
P01130 |
LDLR | Low-density lipoprotein receptor | Homo sapiens | 224 | Detail |
Q14790 |
CASP8 | Caspase-8 | Homo sapiens | 219 | Detail |
O43318 |
MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | Homo sapiens | 178 | Detail |
P29466 |
CASP1 | Caspase-1 | Homo sapiens | 173 | Detail |
O15111 |
CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | Homo sapiens | 170 | Detail |
Q9NZJ5 |
EIF2AK3 | Eukaryotic translation initiation factor 2-alpha kinase 3 | Homo sapiens | 154 | Detail |
Q13557 |
CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 150 | Detail |
P01584 |
IL1B | Interleukin-1 beta | Homo sapiens | 148 | Detail |
P01375 |
TNF | Tumor necrosis factor | Homo sapiens | 144 | Detail |
P19838 |
NFKB1 | Nuclear factor NF-kappa-B p105 subunit | Homo sapiens | 140 | Detail |
Q04206 |
RELA | Transcription factor p65 | Homo sapiens | 134 | Detail |
Q13555 |
CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 123 | Detail |
P55212 |
CASP6 | Caspase-6 | Homo sapiens | 112 | Detail |
P16581 |
SELE | E-selectin | Homo sapiens | 99 | Detail |
Q15750 |
TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | Homo sapiens | 97 | Detail |
P29474 |
NOS3 | Nitric oxide synthase 3 | Homo sapiens | 94 | Detail |
P48443 |
RXRG | Retinoic acid receptor RXR-gamma | Homo sapiens | 94 | Detail |
P28702 |
RXRB | Retinoic acid receptor RXR-beta | Homo sapiens | 87 | Detail |
Q99683 |
MAP3K5 | Mitogen-activated protein kinase kinase kinase 5 | Homo sapiens | 81 | Detail |
Q9UQM7 |
CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 75 | Detail |
P05412 |
JUN | Transcription factor Jun | Homo sapiens | 69 | Detail |
Q13554 |
CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 68 | Detail |
P14625 |
HSP90B1 | Endoplasmin | Homo sapiens | 67 | Detail |
P13500 |
CCL2 | C-C motif chemokine 2 | Homo sapiens | 65 | Detail |
P19320 |
VCAM1 | Vascular cell adhesion protein 1 | Homo sapiens | 64 | Detail |
P10632 |
CYP2C8 | Cytochrome P450 2C8 | Homo sapiens | 62 | Detail |
P40763 |
STAT3 | Signal transducer and activator of transcription 3 | Homo sapiens | 49 | Detail |
P04114 |
APOB | Apolipoprotein B-100 | Homo sapiens | 47 | Detail |
O75460 |
ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | Homo sapiens | 46 | Detail |
P55957 |
BID | BH3-interacting domain death agonist | Homo sapiens | 41 | Detail |
P55211 |
CASP9 | Caspase-9 | Homo sapiens | 32 | Detail |
P45985 |
MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | Homo sapiens | 31 | Detail |
P11509 |
CYP2A6 | Cytochrome P450 2A6 | Homo sapiens | 29 | Detail |
P48454 |
PPP3CC | Serine/threonine-protein phosphatase 2B catalytic subunit ga | Homo sapiens | 27 | Detail |
Q92934 |
BAD | Bcl2-associated agonist of cell death | Homo sapiens | 27 | Detail |
P01100 |
FOS | Protein c-Fos | Homo sapiens | 25 | Detail |
P20813 |
CYP2B6 | Cytochrome P450 2B6 | Homo sapiens | 22 | Detail |
P05198 |
EIF2S1 | Eukaryotic translation initiation factor 2 subunit 1 | Homo sapiens | 22 | Detail |
P05231 |
IL6 | Interleukin-6 | Homo sapiens | 17 | Detail |
P52564 |
MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | Homo sapiens | 17 | Detail |
Q96P20 |
NLRP3 | NACHT, LRR and PYD domains-containing protein 3 | Homo sapiens | 16 | Detail |
P60953 |
CDC42 | Cell division control protein 42 homolog | Homo sapiens | 16 | Detail |
O14733 |
MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 | Homo sapiens | 15 | Detail |
P01112 |
HRAS | GTPase HRas | Homo sapiens | 14 | Detail |
O60603 |
TLR2 | Toll-like receptor 2 | Homo sapiens | 14 | Detail |
P17861 |
XBP1 | X-box-binding protein 1 | Homo sapiens | 14 | Detail |
Q9Y2C9 |
TLR6 | Toll-like receptor 6 | Homo sapiens | 13 | Detail |
Q9Y6K9 |
IKBKG | NF-kappa-B essential modulator | Homo sapiens | 13 | Detail |
P46734 |
MAP2K3 | Dual specificity mitogen-activated protein kinase kinase 3 | Homo sapiens | 12 | Detail |
P13501 |
CCL5 | C-C motif chemokine 5 | Homo sapiens | 12 | Detail |
P10145 |
CXCL8 | Interleukin-8 | Homo sapiens | 9 | Detail |
O00206 |
TLR4 | Toll-like receptor 4 | Homo sapiens | 9 | Detail |
P51589 |
CYP2J2 | Cytochrome P450 2J2 | Homo sapiens | 8 | Detail |
P16109 |
SELP | P-selectin | Homo sapiens | 8 | Detail |
P0DP23 |
CALM1 | Calmodulin-1 | Homo sapiens | 8 | Detail |
P09086 |
POU2F2 | POU domain, class 2, transcription factor 2 | Homo sapiens | 7 | Detail |
P04839 |
CYBB | NADPH oxidase 2 | Homo sapiens | 6 | Detail |
Q9Y6Y9 |
LY96 | Lymphocyte antigen 96 | Homo sapiens | 6 | Detail |
P0DMV8 |
HSPA1A | Heat shock 70 kDa protein 1A | Homo sapiens | 6 | Detail |
P11021 |
HSPA5 | Endoplasmic reticulum chaperone BiP | Homo sapiens | 6 | Detail |
Q9Y5S8 |
NOX1 | NADPH oxidase 1 | Homo sapiens | 5 | Detail |
O14727 |
APAF1 | Apoptotic protease-activating factor 1 | Homo sapiens | 5 | Detail |
P11142 |
HSPA8 | Heat shock cognate 71 kDa protein | Homo sapiens | 5 | Detail |
P10147 |
CCL3 | C-C motif chemokine 3 | Homo sapiens | 5 | Detail |
P14598 |
NCF1 | Neutrophil cytosol factor 1 | Homo sapiens | 5 | Detail |
Q14643 |
ITPR1 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 | Homo sapiens | 4 | Detail |
Q08209 |
PPP3CA | Protein phosphatase 3 catalytic subunit alpha | Homo sapiens | 4 | Detail |
P25942 |
CD40 | Tumor necrosis factor receptor superfamily member 5 | Homo sapiens | 4 | Detail |
P29965 |
CD40LG | CD40 ligand | Homo sapiens | 4 | Detail |
P20853 |
CYP2A7 | Cytochrome P450 2A7 | Homo sapiens | 3 | Detail |
P10809 |
HSPD1 | 60 kDa heat shock protein, mitochondrial | Homo sapiens | 3 | Detail |
P63000 |
RAC1 | Ras-related C3 botulinum toxin substrate 1 | Homo sapiens | 3 | Detail |
P19174 |
PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase ga | Homo sapiens | 2 | Detail |
P19438 |
TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A | Homo sapiens | 2 | Detail |
P08571 |
CD14 | Monocyte differentiation antigen CD14 | Homo sapiens | 2 | Detail |
Q92844 |
TANK | TRAF family member-associated NF-kappa-B activator | Homo sapiens | 1 | Detail |
Q15109 |
AGER | Advanced glycosylation end product-specific receptor | Homo sapiens | 1 | Detail |
Q96HE7 |
ERO1A | ERO1-like protein alpha | Homo sapiens | 1 | Detail |
P0DMV9 |
HSPA1B | Heat shock 70 kDa protein 1B | Homo sapiens | 1 | Detail |
P34932 |
HSPA4 | Heat shock 70 kDa protein 4 | Homo sapiens | 1 | Detail |
P25963 |
NFKBIA | NF-kappa-B inhibitor alpha | Homo sapiens | 1 | Detail |
P99999 |
CYCS | Cytochrome c | Homo sapiens | 1 | Detail |
P14859 |
POU2F1 | POU domain, class 2, transcription factor 1 | Homo sapiens | 1 | Detail |
Q07812 |
BAX | Apoptosis regulator BAX | Homo sapiens | 1 | Detail |
Q12933 |
TRAF2 | TNF receptor-associated factor 2 | Homo sapiens | 1 | Detail |
P15498 |
VAV1 | Proto-oncogene vav | Homo sapiens | 1 | Detail |
O00220 |
TNFRSF10A | Tumor necrosis factor receptor superfamily member 10A | Homo sapiens | 1 | Detail |