Diabetic cardiomyopathy
hsa05415 138 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
P42336 |
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 5616 | Detail |
O00329 |
PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 3772 | Detail |
P08253 |
MMP2 | 72 kDa type IV collagenase | Homo sapiens | 2719 | Detail |
P27986 |
PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | Homo sapiens | 2553 | Detail |
P42345 |
MTOR | Serine/threonine-protein kinase mTOR | Homo sapiens | 2517 | Detail |
P49841 |
GSK3B | Glycogen synthase kinase-3 beta | Homo sapiens | 2206 | Detail |
P42338 |
PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 1951 | Detail |
P14780 |
MMP9 | Matrix metalloproteinase-9 | Homo sapiens | 1941 | Detail |
Q16539 |
MAPK14 | Mitogen-activated protein kinase 14 | Homo sapiens | 1754 | Detail |
P31749 |
AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens | 1633 | Detail |
P31751 |
AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens | 896 | Detail |
P09874 |
PARP1 | Poly [ADP-ribose] polymerase 1 | Homo sapiens | 886 | Detail |
P45983 |
MAPK8 | Mitogen-activated protein kinase 8 | Homo sapiens | 748 | Detail |
Q05655 |
PRKCD | Protein kinase C delta type | Homo sapiens | 742 | Detail |
P30556 |
AGTR1 | Type-1 angiotensin II receptor | Homo sapiens | 696 | Detail |
P17252 |
PRKCA | Protein kinase C alpha type | Homo sapiens | 679 | Detail |
P45984 |
MAPK9 | Mitogen-activated protein kinase 9 | Homo sapiens | 676 | Detail |
P06213 |
INSR | Insulin receptor | Homo sapiens | 656 | Detail |
P53779 |
MAPK10 | Mitogen-activated protein kinase 10 | Homo sapiens | 625 | Detail |
P53778 |
MAPK12 | Mitogen-activated protein kinase 12 | Homo sapiens | 606 | Detail |
Q15759 |
MAPK11 | Mitogen-activated protein kinase 11 | Homo sapiens | 594 | Detail |
P07339 |
CTSD | Cathepsin D | Homo sapiens | 551 | Detail |
O15264 |
MAPK13 | Mitogen-activated protein kinase 13 | Homo sapiens | 533 | Detail |
Q15119 |
PDK2 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozym | Homo sapiens | 493 | Detail |
O00459 |
PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | Homo sapiens | 485 | Detail |
P05771 |
PRKCB | Protein kinase C beta type | Homo sapiens | 457 | Detail |
P36897 |
TGFBR1 | TGF-beta receptor type-1 | Homo sapiens | 428 | Detail |
Q16654 |
PDK4 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozym | Homo sapiens | 381 | Detail |
Q15120 |
PDK3 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozym | Homo sapiens | 362 | Detail |
Q07869 |
PPARA | Peroxisome proliferator-activated receptor alpha | Homo sapiens | 355 | Detail |
Q9Y243 |
AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens | 321 | Detail |
P05129 |
PRKCG | Protein kinase C gamma type | Homo sapiens | 311 | Detail |
Q92569 |
PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | Homo sapiens | 289 | Detail |
P12821 |
ACE | Angiotensin-converting enzyme | Homo sapiens | 233 | Detail |
P11166 |
SLC2A1 | Solute carrier family 2, facilitated glucose transporter mem | Homo sapiens | 189 | Detail |
P30405 |
PPIF | Peptidyl-prolyl cis-trans isomerase F, mitochondrial | Homo sapiens | 172 | Detail |
Q05513 |
PRKCZ | Protein kinase C zeta type | Homo sapiens | 166 | Detail |
Q13557 |
CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 150 | Detail |
P37173 |
TGFBR2 | TGF-beta receptor type-2 | Homo sapiens | 144 | Detail |
P19838 |
NFKB1 | Nuclear factor NF-kappa-B p105 subunit | Homo sapiens | 140 | Detail |
Q04206 |
RELA | Transcription factor p65 | Homo sapiens | 134 | Detail |
Q13555 |
CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 123 | Detail |
P00797 |
REN | Renin | Homo sapiens | 120 | Detail |
P29474 |
NOS3 | Nitric oxide synthase 3 | Homo sapiens | 94 | Detail |
Q9UQM7 |
CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 75 | Detail |
Q13554 |
CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 68 | Detail |
P23946 |
CMA1 | Chymase | Homo sapiens | 67 | Detail |
Q92523 |
CPT1B | Carnitine O-palmitoyltransferase 1, muscle isoform | Homo sapiens | 51 | Detail |
P23786 |
CPT2 | Carnitine O-palmitoyltransferase 2, mitochondrial | Homo sapiens | 40 | Detail |
P14672 |
SLC2A4 | Solute carrier family 2, facilitated glucose transporter mem | Homo sapiens | 40 | Detail |
P84022 |
SMAD3 | SMAD family member 3 | Homo sapiens | 11 | Detail |
Q15796 |
SMAD2 | SMAD family member 2 | Homo sapiens | 10 | Detail |
P00403 |
MT-CO2 | Cytochrome c oxidase subunit 2 | Homo sapiens | 8 | Detail |
Q15257 |
PTPA | Serine/threonine-protein phosphatase 2A activator | Homo sapiens | 8 | Detail |
P01137 |
TGFB1 | Transforming growth factor beta-1 proprotein | Homo sapiens | 8 | Detail |
P04839 |
CYBB | NADPH oxidase 2 | Homo sapiens | 6 | Detail |
P16615 |
ATP2A2 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | Homo sapiens | 5 | Detail |
P36873 |
PPP1CC | Serine/threonine-protein phosphatase PP1-gamma catalytic sub | Homo sapiens | 5 | Detail |
P14598 |
NCF1 | Neutrophil cytosol factor 1 | Homo sapiens | 5 | Detail |
P03905 |
MT-ND4 | NADH-ubiquinone oxidoreductase chain 4 | Homo sapiens | 4 | Detail |
P28331 |
NDUFS1 | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | Homo sapiens | 4 | Detail |
O75306 |
NDUFS2 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitoc | Homo sapiens | 4 | Detail |
Q9P0J0 |
NDUFA13 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | Homo sapiens | 4 | Detail |
P12236 |
SLC25A6 | ADP/ATP translocase 3 | Homo sapiens | 3 | Detail |
O75251 |
NDUFS7 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitoc | Homo sapiens | 3 | Detail |
P00395 |
MT-CO1 | Cytochrome c oxidase subunit 1 | Homo sapiens | 3 | Detail |
P00156 |
MT-CYB | Cytochrome b | Homo sapiens | 3 | Detail |
P03886 |
MT-ND1 | NADH-ubiquinone oxidoreductase chain 1 | Homo sapiens | 3 | Detail |
Q16718 |
NDUFA5 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | Homo sapiens | 3 | Detail |
O95299 |
NDUFA10 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | Homo sapiens | 3 | Detail |
O95169 |
NDUFB8 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, | Homo sapiens | 3 | Detail |
Q9Y6M9 |
NDUFB9 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | Homo sapiens | 3 | Detail |
O96000 |
NDUFB10 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | Homo sapiens | 3 | Detail |
O75489 |
NDUFS3 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitoc | Homo sapiens | 3 | Detail |
P19404 |
NDUFV2 | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondria | Homo sapiens | 3 | Detail |
P63000 |
RAC1 | Ras-related C3 botulinum toxin substrate 1 | Homo sapiens | 3 | Detail |
P15153 |
RAC2 | Ras-related C3 botulinum toxin substrate 2 | Homo sapiens | 3 | Detail |
O75947 |
ATP5PD | ATP synthase peripheral stalk subunit d, mitochondrial | Homo sapiens | 2 | Detail |
Q86Y39 |
NDUFA11 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | Homo sapiens | 2 | Detail |
P08574 |
CYC1 | Cytochrome c1, heme protein, mitochondrial | Homo sapiens | 2 | Detail |
Q06210 |
GFPT1 | Glutamine--fructose-6-phosphate aminotransferase [isomerizin | Homo sapiens | 2 | Detail |
P05141 |
SLC25A5 | ADP/ATP translocase 2 | Homo sapiens | 2 | Detail |
P00390 |
GSR | Glutathione reductase, mitochondrial | Homo sapiens | 2 | Detail |
P35568 |
IRS1 | Insulin receptor substrate 1 | Homo sapiens | 2 | Detail |
P00846 |
MT-ATP6 | ATP synthase F(0) complex subunit a | Homo sapiens | 2 | Detail |
P03891 |
MT-ND2 | NADH-ubiquinone oxidoreductase chain 2 | Homo sapiens | 2 | Detail |
P03897 |
MT-ND3 | NADH-ubiquinone oxidoreductase chain 3 | Homo sapiens | 2 | Detail |
P03901 |
MT-ND4L | NADH-ubiquinone oxidoreductase chain 4L | Homo sapiens | 2 | Detail |
P03915 |
MT-ND5 | NADH-ubiquinone oxidoreductase chain 5 | Homo sapiens | 2 | Detail |
P03923 |
MT-ND6 | NADH-ubiquinone oxidoreductase chain 6 | Homo sapiens | 2 | Detail |
O15239 |
NDUFA1 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | Homo sapiens | 2 | Detail |
O43678 |
NDUFA2 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | Homo sapiens | 2 | Detail |
O95167 |
NDUFA3 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 | Homo sapiens | 2 | Detail |
O00483 |
COXFA4 | Cytochrome c oxidase subunit FA4 | Homo sapiens | 2 | Detail |
P56556 |
NDUFA6 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | Homo sapiens | 2 | Detail |
O95182 |
NDUFA7 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 | Homo sapiens | 2 | Detail |
P51970 |
NDUFA8 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | Homo sapiens | 2 | Detail |
Q16795 |
NDUFA9 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9 | Homo sapiens | 2 | Detail |
O14561 |
NDUFAB1 | Acyl carrier protein, mitochondrial | Homo sapiens | 2 | Detail |
O75438 |
NDUFB1 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 | Homo sapiens | 2 | Detail |
O95178 |
NDUFB2 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, | Homo sapiens | 2 | Detail |
O43676 |
NDUFB3 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | Homo sapiens | 2 | Detail |
O95168 |
NDUFB4 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 | Homo sapiens | 2 | Detail |
O43674 |
NDUFB5 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, | Homo sapiens | 2 | Detail |
O95139 |
NDUFB6 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | Homo sapiens | 2 | Detail |
P17568 |
NDUFB7 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | Homo sapiens | 2 | Detail |
O43677 |
NDUFC1 | NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial | Homo sapiens | 2 | Detail |
O95298 |
NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | Homo sapiens | 2 | Detail |
P49821 |
NDUFV1 | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondria | Homo sapiens | 2 | Detail |
O43181 |
NDUFS4 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitoc | Homo sapiens | 2 | Detail |
O43920 |
NDUFS5 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 | Homo sapiens | 2 | Detail |
O75380 |
NDUFS6 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitoc | Homo sapiens | 2 | Detail |
O00217 |
NDUFS8 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitoc | Homo sapiens | 2 | Detail |
P56181 |
NDUFV3 | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondria | Homo sapiens | 2 | Detail |
O14983 |
ATP2A1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Homo sapiens | 2 | Detail |
Q93084 |
ATP2A3 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | Homo sapiens | 2 | Detail |
P08559 |
PDHA1 | Pyruvate dehydrogenase E1 component subunit alpha, somatic f | Homo sapiens | 2 | Detail |
Q9NX14 |
NDUFB11 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11 | Homo sapiens | 2 | Detail |
P62136 |
PPP1CA | Serine/threonine-protein phosphatase PP1-alpha catalytic sub | Homo sapiens | 2 | Detail |
Q9UI09 |
NDUFA12 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | Homo sapiens | 2 | Detail |
Q9NRX3 |
COXFA4L2 | Cytochrome c oxidase hypoxia associated subunit FA4L2 | Homo sapiens | 2 | Detail |
P61812 |
TGFB2 | Transforming growth factor beta-2 proprotein | Homo sapiens | 2 | Detail |
P22695 |
UQCRC2 | Cytochrome b-c1 complex subunit 2, mitochondrial | Homo sapiens | 2 | Detail |
P21796 |
VDAC1 | Non-selective voltage-gated ion channel VDAC1 | Homo sapiens | 2 | Detail |
Q9Y277 |
VDAC3 | Non-selective voltage-gated ion channel VDAC3 | Homo sapiens | 2 | Detail |
P13073 |
COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | Homo sapiens | 1 | Detail |
P12074 |
COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | Homo sapiens | 1 | Detail |
P09669 |
COX6C | Cytochrome c oxidase subunit 6C | Homo sapiens | 1 | Detail |
Q15109 |
AGER | Advanced glycosylation end product-specific receptor | Homo sapiens | 1 | Detail |
P11413 |
G6PD | Glucose-6-phosphate 1-dehydrogenase | Homo sapiens | 1 | Detail |
P04406 |
GAPDH | Glyceraldehyde-3-phosphate dehydrogenase | Homo sapiens | 1 | Detail |
P06576 |
ATP5F1B | ATP synthase F(1) complex subunit beta, mitochondrial | Homo sapiens | 1 | Detail |
P24539 |
ATP5PB | ATP synthase peripheral stalk subunit b, mitochondrial | Homo sapiens | 1 | Detail |
P48047 |
ATP5PO | ATP synthase peripheral stalk subunit OSCP, mitochondrial | Homo sapiens | 1 | Detail |
P31040 |
SDHA | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, m | Homo sapiens | 1 | Detail |
P31930 |
UQCRC1 | Cytochrome b-c1 complex subunit 1, mitochondrial | Homo sapiens | 1 | Detail |
P45880 |
VDAC2 | Non-selective voltage-gated ion channel VDAC2 | Homo sapiens | 1 | Detail |
P01019 |
AGT | Angiotensinogen | Homo sapiens | 0 | Detail |