PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05235 63 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
O60674 |
JAK2 | Tyrosine-protein kinase JAK2 | Homo sapiens | 10545 | Detail |
P23458 |
JAK1 | Tyrosine-protein kinase JAK1 | Homo sapiens | 8920 | Detail |
P42336 |
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 5616 | Detail |
O00329 |
PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 3772 | Detail |
P00533 |
EGFR | Epidermal growth factor receptor | Homo sapiens | 3433 | Detail |
Q9NZQ7 |
CD274 | Programmed cell death 1 ligand 1 | Homo sapiens | 3096 | Detail |
Q15116 |
PDCD1 | Programmed cell death protein 1 | Homo sapiens | 2775 | Detail |
P27986 |
PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | Homo sapiens | 2553 | Detail |
P42345 |
MTOR | Serine/threonine-protein kinase mTOR | Homo sapiens | 2517 | Detail |
P04049 |
RAF1 | RAF proto-oncogene serine/threonine-protein kinase | Homo sapiens | 2133 | Detail |
P42338 |
PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 1951 | Detail |
P01116 |
KRAS | GTPase KRas | Homo sapiens | 1811 | Detail |
Q16539 |
MAPK14 | Mitogen-activated protein kinase 14 | Homo sapiens | 1754 | Detail |
P31749 |
AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens | 1633 | Detail |
P06239 |
LCK | Tyrosine-protein kinase Lck | Homo sapiens | 1537 | Detail |
P23443 |
RPS6KB1 | Ribosomal protein S6 kinase beta-1 | Homo sapiens | 1180 | Detail |
Q9NR96 |
TLR9 | Toll-like receptor 9 | Homo sapiens | 1027 | Detail |
P01111 |
NRAS | GTPase NRas | Homo sapiens | 923 | Detail |
P28482 |
MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens | 906 | Detail |
P31751 |
AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens | 896 | Detail |
Q04759 |
PRKCQ | Protein kinase C theta type | Homo sapiens | 750 | Detail |
Q9UM73 |
ALK | ALK tyrosine kinase receptor | Homo sapiens | 712 | Detail |
P68400 |
CSNK2A1 | Casein kinase II subunit alpha | Homo sapiens | 639 | Detail |
P53778 |
MAPK12 | Mitogen-activated protein kinase 12 | Homo sapiens | 606 | Detail |
Q15759 |
MAPK11 | Mitogen-activated protein kinase 11 | Homo sapiens | 594 | Detail |
Q02750 |
MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens | 543 | Detail |
O15264 |
MAPK13 | Mitogen-activated protein kinase 13 | Homo sapiens | 533 | Detail |
O00459 |
PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | Homo sapiens | 485 | Detail |
O14920 |
IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | Homo sapiens | 411 | Detail |
P19784 |
CSNK2A2 | Casein kinase II subunit alpha' | Homo sapiens | 400 | Detail |
P67870 |
CSNK2B | Casein kinase II subunit beta | Homo sapiens | 356 | Detail |
Q9Y243 |
AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens | 321 | Detail |
Q92569 |
PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | Homo sapiens | 289 | Detail |
P27361 |
MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens | 234 | Detail |
Q06124 |
PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | Homo sapiens | 214 | Detail |
O15111 |
CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | Homo sapiens | 170 | Detail |
P15260 |
IFNGR1 | Interferon gamma receptor 1 | Homo sapiens | 150 | Detail |
P36507 |
MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | Homo sapiens | 146 | Detail |
P19838 |
NFKB1 | Nuclear factor NF-kappa-B p105 subunit | Homo sapiens | 140 | Detail |
Q04206 |
RELA | Transcription factor p65 | Homo sapiens | 134 | Detail |
Q8NEV1 |
CSNK2A3 | Casein kinase II subunit alpha 3 | Homo sapiens | 96 | Detail |
Q16665 |
HIF1A | Hypoxia-inducible factor 1-alpha | Homo sapiens | 81 | Detail |
P05412 |
JUN | Transcription factor Jun | Homo sapiens | 69 | Detail |
P43403 |
ZAP70 | Tyrosine-protein kinase ZAP-70 | Homo sapiens | 67 | Detail |
P40763 |
STAT3 | Signal transducer and activator of transcription 3 | Homo sapiens | 49 | Detail |
Q9HC35 |
EML4 | Echinoderm microtubule-associated protein-like 4 | Homo sapiens | 37 | Detail |
P48454 |
PPP3CC | Serine/threonine-protein phosphatase 2B catalytic subunit ga | Homo sapiens | 27 | Detail |
Q99759 |
MAP3K3 | Mitogen-activated protein kinase kinase kinase 3 | Homo sapiens | 26 | Detail |
P01100 |
FOS | Protein c-Fos | Homo sapiens | 25 | Detail |
P52564 |
MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | Homo sapiens | 17 | Detail |
P01112 |
HRAS | GTPase HRas | Homo sapiens | 14 | Detail |
O60603 |
TLR2 | Toll-like receptor 2 | Homo sapiens | 14 | Detail |
O95267 |
RASGRP1 | RAS guanyl-releasing protein 1 | Homo sapiens | 13 | Detail |
Q9UBS0 |
RPS6KB2 | Ribosomal protein S6 kinase beta-2 | Homo sapiens | 13 | Detail |
Q9Y6K9 |
IKBKG | NF-kappa-B essential modulator | Homo sapiens | 13 | Detail |
P46734 |
MAP2K3 | Dual specificity mitogen-activated protein kinase kinase 3 | Homo sapiens | 12 | Detail |
P29350 |
PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | Homo sapiens | 12 | Detail |
O00206 |
TLR4 | Toll-like receptor 4 | Homo sapiens | 9 | Detail |
Q08209 |
PPP3CA | Protein phosphatase 3 catalytic subunit alpha | Homo sapiens | 4 | Detail |
P42224 |
STAT1 | Signal transducer and activator of transcription 1-alpha/bet | Homo sapiens | 4 | Detail |
P01730 |
CD4 | T-cell surface glycoprotein CD4 | Homo sapiens | 4 | Detail |
P19174 |
PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase ga | Homo sapiens | 2 | Detail |
P25963 |
NFKBIA | NF-kappa-B inhibitor alpha | Homo sapiens | 1 | Detail |