Central carbon metabolism in cancer
hsa05230 57 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
P42336 |
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 5616 | Detail |
O00329 |
PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 3772 | Detail |
P00533 |
EGFR | Epidermal growth factor receptor | Homo sapiens | 3433 | Detail |
P11362 |
FGFR1 | Fibroblast growth factor receptor 1 | Homo sapiens | 3320 | Detail |
P22607 |
FGFR3 | Fibroblast growth factor receptor 3 | Homo sapiens | 2742 | Detail |
P27986 |
PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | Homo sapiens | 2553 | Detail |
P42345 |
MTOR | Serine/threonine-protein kinase mTOR | Homo sapiens | 2517 | Detail |
P36888 |
FLT3 | Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens | 2188 | Detail |
P04049 |
RAF1 | RAF proto-oncogene serine/threonine-protein kinase | Homo sapiens | 2133 | Detail |
P21802 |
FGFR2 | Fibroblast growth factor receptor 2 | Homo sapiens | 2130 | Detail |
P04626 |
ERBB2 | Receptor tyrosine-protein kinase erbB-2 | Homo sapiens | 2123 | Detail |
P42338 |
PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 1951 | Detail |
P01116 |
KRAS | GTPase KRas | Homo sapiens | 1811 | Detail |
P31749 |
AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens | 1633 | Detail |
P09619 |
PDGFRB | Platelet-derived growth factor receptor beta | Homo sapiens | 1527 | Detail |
P04637 |
TP53 | Cellular tumor antigen p53 | Homo sapiens | 1173 | Detail |
P10721 |
KIT | Mast/stem cell growth factor receptor Kit | Homo sapiens | 1134 | Detail |
P04629 |
NTRK1 | High affinity nerve growth factor receptor | Homo sapiens | 1127 | Detail |
P08581 |
MET | Hepatocyte growth factor receptor | Homo sapiens | 1125 | Detail |
P01111 |
NRAS | GTPase NRas | Homo sapiens | 923 | Detail |
P28482 |
MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens | 906 | Detail |
P31751 |
AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens | 896 | Detail |
P16234 |
PDGFRA | Platelet-derived growth factor receptor alpha | Homo sapiens | 860 | Detail |
P07949 |
RET | Proto-oncogene tyrosine-protein kinase receptor Ret | Homo sapiens | 656 | Detail |
Q02750 |
MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens | 543 | Detail |
Q15118 |
PDK1 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozym | Homo sapiens | 524 | Detail |
Q16288 |
NTRK3 | NT-3 growth factor receptor | Homo sapiens | 503 | Detail |
O00459 |
PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | Homo sapiens | 485 | Detail |
Q9Y243 |
AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens | 321 | Detail |
Q92569 |
PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | Homo sapiens | 289 | Detail |
P27361 |
MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens | 234 | Detail |
P11166 |
SLC2A1 | Solute carrier family 2, facilitated glucose transporter mem | Homo sapiens | 189 | Detail |
O75874 |
IDH1 | Isocitrate dehydrogenase [NADP] cytoplasmic | Homo sapiens | 148 | Detail |
P36507 |
MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | Homo sapiens | 146 | Detail |
P00338 |
LDHA | L-lactate dehydrogenase A chain | Homo sapiens | 125 | Detail |
P07195 |
LDHB | L-lactate dehydrogenase B chain | Homo sapiens | 119 | Detail |
Q16665 |
HIF1A | Hypoxia-inducible factor 1-alpha | Homo sapiens | 81 | Detail |
P48735 |
IDH2 | Isocitrate dehydrogenase [NADP], mitochondrial | Homo sapiens | 78 | Detail |
Q9NTG7 |
SIRT3 | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | Homo sapiens | 64 | Detail |
O94925 |
GLS | Glutaminase kidney isoform, mitochondrial | Homo sapiens | 52 | Detail |
P35557 |
GCK | Hexokinase-4 | Homo sapiens | 39 | Detail |
O15427 |
SLC16A3 | Monocarboxylate transporter 4 | Homo sapiens | 33 | Detail |
P01106 |
MYC | Myc proto-oncogene protein | Homo sapiens | 19 | Detail |
P01112 |
HRAS | GTPase HRas | Homo sapiens | 14 | Detail |
P19367 |
HK1 | Hexokinase-1 | Homo sapiens | 12 | Detail |
P52789 |
HK2 | Hexokinase-2 | Homo sapiens | 11 | Detail |
P11168 |
SLC2A2 | Solute carrier family 2, facilitated glucose transporter mem | Homo sapiens | 10 | Detail |
Q9UI32 |
GLS2 | Glutaminase liver isoform, mitochondrial | Homo sapiens | 4 | Detail |
P14618 |
PKM | Pyruvate kinase PKM | Homo sapiens | 4 | Detail |
V9HWB9 |
HEL-S-133P | L-lactate dehydrogenase | Homo sapiens | 3 | Detail |
P08559 |
PDHA1 | Pyruvate dehydrogenase E1 component subunit alpha, somatic f | Homo sapiens | 2 | Detail |
Q01813 |
PFKP | ATP-dependent 6-phosphofructokinase, platelet type | Homo sapiens | 2 | Detail |
P18669 |
PGAM1 | Phosphoglycerate mutase 1 | Homo sapiens | 2 | Detail |
Q15758 |
SLC1A5 | Neutral amino acid transporter B(0) | Homo sapiens | 2 | Detail |
P11413 |
G6PD | Glucose-6-phosphate 1-dehydrogenase | Homo sapiens | 1 | Detail |
Q8N6T7 |
SIRT6 | NAD-dependent protein deacylase sirtuin-6 | Homo sapiens | 1 | Detail |
P17858 |
PFKL | ATP-dependent 6-phosphofructokinase, liver type | Homo sapiens | 1 | Detail |