Colorectal cancer
hsa05210 61 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
P42336 |
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 5616 | Detail |
O00329 |
PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 3772 | Detail |
P00533 |
EGFR | Epidermal growth factor receptor | Homo sapiens | 3433 | Detail |
P15056 |
BRAF | Serine/threonine-protein kinase B-raf | Homo sapiens | 2643 | Detail |
P27986 |
PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | Homo sapiens | 2553 | Detail |
P42345 |
MTOR | Serine/threonine-protein kinase mTOR | Homo sapiens | 2517 | Detail |
P49841 |
GSK3B | Glycogen synthase kinase-3 beta | Homo sapiens | 2206 | Detail |
P04049 |
RAF1 | RAF proto-oncogene serine/threonine-protein kinase | Homo sapiens | 2133 | Detail |
P42338 |
PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 1951 | Detail |
O43521 |
BCL2L11 | Bcl-2-like protein 11 | Homo sapiens | 1888 | Detail |
P01116 |
KRAS | GTPase KRas | Homo sapiens | 1811 | Detail |
P24385 |
CCND1 | G1/S-specific cyclin-D1 | Homo sapiens | 1643 | Detail |
P31749 |
AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens | 1633 | Detail |
P23443 |
RPS6KB1 | Ribosomal protein S6 kinase beta-1 | Homo sapiens | 1180 | Detail |
P04637 |
TP53 | Cellular tumor antigen p53 | Homo sapiens | 1173 | Detail |
P10415 |
BCL2 | Apoptosis regulator Bcl-2 | Homo sapiens | 1065 | Detail |
P01111 |
NRAS | GTPase NRas | Homo sapiens | 923 | Detail |
P28482 |
MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens | 906 | Detail |
P31751 |
AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens | 896 | Detail |
Q07889 |
SOS1 | Son of sevenless homolog 1 | Homo sapiens | 766 | Detail |
P45983 |
MAPK8 | Mitogen-activated protein kinase 8 | Homo sapiens | 748 | Detail |
P45984 |
MAPK9 | Mitogen-activated protein kinase 9 | Homo sapiens | 676 | Detail |
P53779 |
MAPK10 | Mitogen-activated protein kinase 10 | Homo sapiens | 625 | Detail |
Q02750 |
MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens | 543 | Detail |
O00459 |
PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | Homo sapiens | 485 | Detail |
P42574 |
CASP3 | Caspase-3 | Homo sapiens | 444 | Detail |
P36897 |
TGFBR1 | TGF-beta receptor type-1 | Homo sapiens | 428 | Detail |
Q9Y243 |
AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens | 321 | Detail |
Q92569 |
PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | Homo sapiens | 289 | Detail |
P27361 |
MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens | 234 | Detail |
P35222 |
CTNNB1 | Catenin beta-1 | Homo sapiens | 176 | Detail |
Q9NQB0 |
TCF7L2 | Transcription factor 7-like 2 | Homo sapiens | 154 | Detail |
P36507 |
MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | Homo sapiens | 146 | Detail |
P37173 |
TGFBR2 | TGF-beta receptor type-2 | Homo sapiens | 144 | Detail |
P05412 |
JUN | Transcription factor Jun | Homo sapiens | 69 | Detail |
P10398 |
ARAF | Serine/threonine-protein kinase A-Raf | Homo sapiens | 37 | Detail |
P55211 |
CASP9 | Caspase-9 | Homo sapiens | 32 | Detail |
Q92934 |
BAD | Bcl2-associated agonist of cell death | Homo sapiens | 27 | Detail |
P01100 |
FOS | Protein c-Fos | Homo sapiens | 25 | Detail |
P01106 |
MYC | Myc proto-oncogene protein | Homo sapiens | 19 | Detail |
P01112 |
HRAS | GTPase HRas | Homo sapiens | 14 | Detail |
Q9UBS0 |
RPS6KB2 | Ribosomal protein S6 kinase beta-2 | Homo sapiens | 13 | Detail |
P84022 |
SMAD3 | SMAD family member 3 | Homo sapiens | 11 | Detail |
Q15796 |
SMAD2 | SMAD family member 2 | Homo sapiens | 10 | Detail |
P01137 |
TGFB1 | Transforming growth factor beta-1 proprotein | Homo sapiens | 8 | Detail |
P15514 |
AREG | Amphiregulin | Homo sapiens | 7 | Detail |
P25054 |
APC | Adenomatous polyposis coli protein | Homo sapiens | 6 | Detail |
Q16611 |
BAK1 | Bcl-2 homologous antagonist/killer | Homo sapiens | 6 | Detail |
P62993 |
GRB2 | Growth factor receptor-bound protein 2 | Homo sapiens | 4 | Detail |
P63000 |
RAC1 | Ras-related C3 botulinum toxin substrate 1 | Homo sapiens | 3 | Detail |
P15153 |
RAC2 | Ras-related C3 botulinum toxin substrate 2 | Homo sapiens | 3 | Detail |
P52701 |
MSH6 | DNA mismatch repair protein Msh6 | Homo sapiens | 2 | Detail |
P60763 |
RAC3 | Ras-related C3 botulinum toxin substrate 3 | Homo sapiens | 2 | Detail |
P36402 |
TCF7 | Transcription factor 7 | Homo sapiens | 2 | Detail |
P61812 |
TGFB2 | Transforming growth factor beta-2 proprotein | Homo sapiens | 2 | Detail |
P38936 |
CDKN1A | Cyclin-dependent kinase inhibitor 1 | Homo sapiens | 1 | Detail |
Q9BXH1 |
BBC3 | Bcl-2-binding component 3, isoforms 1/2 | Homo sapiens | 1 | Detail |
P43246 |
MSH2 | DNA mismatch repair protein Msh2 | Homo sapiens | 1 | Detail |
Q13794 |
PMAIP1 | Phorbol-12-myristate-13-acetate-induced protein 1 | Homo sapiens | 1 | Detail |
P99999 |
CYCS | Cytochrome c | Homo sapiens | 1 | Detail |
Q07812 |
BAX | Apoptosis regulator BAX | Homo sapiens | 1 | Detail |