Chemical carcinogenesis - reactive oxygen species
hsa05208 156 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
P42336 |
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 5616 | Detail |
O00329 |
PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 3772 | Detail |
P00533 |
EGFR | Epidermal growth factor receptor | Homo sapiens | 3433 | Detail |
P15056 |
BRAF | Serine/threonine-protein kinase B-raf | Homo sapiens | 2643 | Detail |
P27986 |
PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | Homo sapiens | 2553 | Detail |
P04049 |
RAF1 | RAF proto-oncogene serine/threonine-protein kinase | Homo sapiens | 2133 | Detail |
P12931 |
SRC | Proto-oncogene tyrosine-protein kinase Src | Homo sapiens | 1978 | Detail |
P42338 |
PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 1951 | Detail |
P01116 |
KRAS | GTPase KRas | Homo sapiens | 1811 | Detail |
Q16539 |
MAPK14 | Mitogen-activated protein kinase 14 | Homo sapiens | 1754 | Detail |
P31749 |
AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens | 1633 | Detail |
P00519 |
ABL1 | Tyrosine-protein kinase ABL1 | Homo sapiens | 1419 | Detail |
P08581 |
MET | Hepatocyte growth factor receptor | Homo sapiens | 1125 | Detail |
P01111 |
NRAS | GTPase NRas | Homo sapiens | 923 | Detail |
P28482 |
MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens | 906 | Detail |
P31751 |
AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens | 896 | Detail |
Q07889 |
SOS1 | Son of sevenless homolog 1 | Homo sapiens | 766 | Detail |
P45983 |
MAPK8 | Mitogen-activated protein kinase 8 | Homo sapiens | 748 | Detail |
Q05655 |
PRKCD | Protein kinase C delta type | Homo sapiens | 742 | Detail |
P45984 |
MAPK9 | Mitogen-activated protein kinase 9 | Homo sapiens | 676 | Detail |
P53779 |
MAPK10 | Mitogen-activated protein kinase 10 | Homo sapiens | 625 | Detail |
P53778 |
MAPK12 | Mitogen-activated protein kinase 12 | Homo sapiens | 606 | Detail |
Q15759 |
MAPK11 | Mitogen-activated protein kinase 11 | Homo sapiens | 594 | Detail |
Q14145 |
KEAP1 | Kelch-like ECH-associated protein 1 | Homo sapiens | 558 | Detail |
Q16236 |
NFE2L2 | Nuclear factor erythroid 2-related factor 2 | Homo sapiens | 557 | Detail |
Q02750 |
MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens | 543 | Detail |
O15264 |
MAPK13 | Mitogen-activated protein kinase 13 | Homo sapiens | 533 | Detail |
P18031 |
PTPN1 | Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens | 511 | Detail |
O00459 |
PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | Homo sapiens | 485 | Detail |
O14920 |
IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | Homo sapiens | 411 | Detail |
P05177 |
CYP1A2 | Cytochrome P450 1A2 | Homo sapiens | 386 | Detail |
O94806 |
PRKD3 | Serine/threonine-protein kinase D3 | Homo sapiens | 354 | Detail |
Q05397 |
PTK2 | Focal adhesion kinase 1 | Homo sapiens | 325 | Detail |
Q9Y243 |
AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens | 321 | Detail |
Q16678 |
CYP1B1 | Cytochrome P450 1B1 | Homo sapiens | 315 | Detail |
P04798 |
CYP1A1 | Cytochrome P450 1A1 | Homo sapiens | 311 | Detail |
O14939 |
PLD2 | Phospholipase D2 | Homo sapiens | 310 | Detail |
Q13393 |
PLD1 | Phospholipase D1 | Homo sapiens | 309 | Detail |
Q92569 |
PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | Homo sapiens | 289 | Detail |
P34913 |
EPHX2 | Bifunctional epoxide hydrolase 2 | Homo sapiens | 257 | Detail |
P27361 |
MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens | 234 | Detail |
O15530 |
PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | Homo sapiens | 228 | Detail |
Q99558 |
MAP3K14 | Mitogen-activated protein kinase kinase kinase 14 | Homo sapiens | 224 | Detail |
Q9BZL6 |
PRKD2 | Serine/threonine-protein kinase D2 | Homo sapiens | 219 | Detail |
Q06124 |
PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | Homo sapiens | 214 | Detail |
Q15139 |
PRKD1 | Serine/threonine-protein kinase D1 | Homo sapiens | 208 | Detail |
P42684 |
ABL2 | Tyrosine-protein kinase ABL2 | Homo sapiens | 202 | Detail |
P30405 |
PPIF | Peptidyl-prolyl cis-trans isomerase F, mitochondrial | Homo sapiens | 172 | Detail |
O15111 |
CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | Homo sapiens | 170 | Detail |
P36507 |
MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | Homo sapiens | 146 | Detail |
P19838 |
NFKB1 | Nuclear factor NF-kappa-B p105 subunit | Homo sapiens | 140 | Detail |
Q04206 |
RELA | Transcription factor p65 | Homo sapiens | 134 | Detail |
P42330 |
AKR1C3 | Aldo-keto reductase family 1 member C3 | Homo sapiens | 118 | Detail |
P07099 |
EPHX1 | Epoxide hydrolase 1 | Homo sapiens | 114 | Detail |
P52895 |
AKR1C2 | Aldo-keto reductase family 1 member C2 | Homo sapiens | 96 | Detail |
Q16665 |
HIF1A | Hypoxia-inducible factor 1-alpha | Homo sapiens | 81 | Detail |
Q99683 |
MAP3K5 | Mitogen-activated protein kinase kinase kinase 5 | Homo sapiens | 81 | Detail |
P05412 |
JUN | Transcription factor Jun | Homo sapiens | 69 | Detail |
P24666 |
ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Homo sapiens | 51 | Detail |
P15692 |
VEGFA | Vascular endothelial growth factor A, long form | Homo sapiens | 44 | Detail |
Q04828 |
AKR1C1 | Aldo-keto reductase family 1 member C1 | Homo sapiens | 39 | Detail |
P10398 |
ARAF | Serine/threonine-protein kinase A-Raf | Homo sapiens | 37 | Detail |
P45985 |
MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | Homo sapiens | 31 | Detail |
P27540 |
ARNT | Aryl hydrocarbon receptor nuclear translocator | Homo sapiens | 30 | Detail |
P28161 |
GSTM2 | Glutathione S-transferase Mu 2 | Homo sapiens | 28 | Detail |
Q92934 |
BAD | Bcl2-associated agonist of cell death | Homo sapiens | 27 | Detail |
P01100 |
FOS | Protein c-Fos | Homo sapiens | 25 | Detail |
P14550 |
AKR1A1 | Aldo-keto reductase family 1 member A1 | Homo sapiens | 23 | Detail |
P05181 |
CYP2E1 | Cytochrome P450 2E1 | Homo sapiens | 16 | Detail |
P15559 |
NQO1 | NAD(P)H dehydrogenase [quinone] 1 | Homo sapiens | 16 | Detail |
O14733 |
MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 | Homo sapiens | 15 | Detail |
P01112 |
HRAS | GTPase HRas | Homo sapiens | 14 | Detail |
Q9Y6K9 |
IKBKG | NF-kappa-B essential modulator | Homo sapiens | 13 | Detail |
P16152 |
CBR1 | Carbonyl reductase [NADPH] 1 | Homo sapiens | 13 | Detail |
P17516 |
AKR1C4 | Aldo-keto reductase family 1 member C4 | Homo sapiens | 10 | Detail |
P08263 |
GSTA1 | Glutathione S-transferase A1 | Homo sapiens | 9 | Detail |
P00403 |
MT-CO2 | Cytochrome c oxidase subunit 2 | Homo sapiens | 8 | Detail |
Q9NPH5 |
NOX4 | NADPH oxidase 4 | Homo sapiens | 8 | Detail |
P35869 |
AHR | Aryl hydrocarbon receptor | Homo sapiens | 5 | Detail |
Q9Y5S8 |
NOX1 | NADPH oxidase 1 | Homo sapiens | 5 | Detail |
P14598 |
NCF1 | Neutrophil cytosol factor 1 | Homo sapiens | 5 | Detail |
P62993 |
GRB2 | Growth factor receptor-bound protein 2 | Homo sapiens | 4 | Detail |
P14210 |
HGF | Hepatocyte growth factor | Homo sapiens | 4 | Detail |
P03905 |
MT-ND4 | NADH-ubiquinone oxidoreductase chain 4 | Homo sapiens | 4 | Detail |
P28331 |
NDUFS1 | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | Homo sapiens | 4 | Detail |
O75306 |
NDUFS2 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitoc | Homo sapiens | 4 | Detail |
Q9P0J0 |
NDUFA13 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | Homo sapiens | 4 | Detail |
P24903 |
CYP2F1 | Cytochrome P450 2F1 | Homo sapiens | 3 | Detail |
P12236 |
SLC25A6 | ADP/ATP translocase 3 | Homo sapiens | 3 | Detail |
O75251 |
NDUFS7 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitoc | Homo sapiens | 3 | Detail |
P00395 |
MT-CO1 | Cytochrome c oxidase subunit 1 | Homo sapiens | 3 | Detail |
P00156 |
MT-CYB | Cytochrome b | Homo sapiens | 3 | Detail |
P03886 |
MT-ND1 | NADH-ubiquinone oxidoreductase chain 1 | Homo sapiens | 3 | Detail |
Q16718 |
NDUFA5 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | Homo sapiens | 3 | Detail |
O95299 |
NDUFA10 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | Homo sapiens | 3 | Detail |
O95169 |
NDUFB8 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, | Homo sapiens | 3 | Detail |
Q9Y6M9 |
NDUFB9 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | Homo sapiens | 3 | Detail |
O96000 |
NDUFB10 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | Homo sapiens | 3 | Detail |
O75489 |
NDUFS3 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitoc | Homo sapiens | 3 | Detail |
P19404 |
NDUFV2 | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondria | Homo sapiens | 3 | Detail |
P63000 |
RAC1 | Ras-related C3 botulinum toxin substrate 1 | Homo sapiens | 3 | Detail |
O75947 |
ATP5PD | ATP synthase peripheral stalk subunit d, mitochondrial | Homo sapiens | 2 | Detail |
Q86Y39 |
NDUFA11 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | Homo sapiens | 2 | Detail |
P08574 |
CYC1 | Cytochrome c1, heme protein, mitochondrial | Homo sapiens | 2 | Detail |
P05141 |
SLC25A5 | ADP/ATP translocase 2 | Homo sapiens | 2 | Detail |
P09210 |
GSTA2 | Glutathione S-transferase A2 | Homo sapiens | 2 | Detail |
P22079 |
LPO | Lactoperoxidase | Homo sapiens | 2 | Detail |
P00846 |
MT-ATP6 | ATP synthase F(0) complex subunit a | Homo sapiens | 2 | Detail |
P03891 |
MT-ND2 | NADH-ubiquinone oxidoreductase chain 2 | Homo sapiens | 2 | Detail |
P03897 |
MT-ND3 | NADH-ubiquinone oxidoreductase chain 3 | Homo sapiens | 2 | Detail |
P03901 |
MT-ND4L | NADH-ubiquinone oxidoreductase chain 4L | Homo sapiens | 2 | Detail |
P03915 |
MT-ND5 | NADH-ubiquinone oxidoreductase chain 5 | Homo sapiens | 2 | Detail |
P03923 |
MT-ND6 | NADH-ubiquinone oxidoreductase chain 6 | Homo sapiens | 2 | Detail |
O15239 |
NDUFA1 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | Homo sapiens | 2 | Detail |
O43678 |
NDUFA2 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | Homo sapiens | 2 | Detail |
O95167 |
NDUFA3 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 | Homo sapiens | 2 | Detail |
O00483 |
COXFA4 | Cytochrome c oxidase subunit FA4 | Homo sapiens | 2 | Detail |
P56556 |
NDUFA6 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | Homo sapiens | 2 | Detail |
O95182 |
NDUFA7 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 | Homo sapiens | 2 | Detail |
P51970 |
NDUFA8 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | Homo sapiens | 2 | Detail |
Q16795 |
NDUFA9 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9 | Homo sapiens | 2 | Detail |
O14561 |
NDUFAB1 | Acyl carrier protein, mitochondrial | Homo sapiens | 2 | Detail |
O75438 |
NDUFB1 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 | Homo sapiens | 2 | Detail |
O95178 |
NDUFB2 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, | Homo sapiens | 2 | Detail |
O43676 |
NDUFB3 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | Homo sapiens | 2 | Detail |
O95168 |
NDUFB4 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 | Homo sapiens | 2 | Detail |
O43674 |
NDUFB5 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, | Homo sapiens | 2 | Detail |
O95139 |
NDUFB6 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | Homo sapiens | 2 | Detail |
P17568 |
NDUFB7 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | Homo sapiens | 2 | Detail |
O43677 |
NDUFC1 | NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial | Homo sapiens | 2 | Detail |
O95298 |
NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | Homo sapiens | 2 | Detail |
P49821 |
NDUFV1 | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondria | Homo sapiens | 2 | Detail |
O43181 |
NDUFS4 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitoc | Homo sapiens | 2 | Detail |
O43920 |
NDUFS5 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 | Homo sapiens | 2 | Detail |
O75380 |
NDUFS6 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitoc | Homo sapiens | 2 | Detail |
O00217 |
NDUFS8 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitoc | Homo sapiens | 2 | Detail |
P56181 |
NDUFV3 | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondria | Homo sapiens | 2 | Detail |
Q9NX14 |
NDUFB11 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11 | Homo sapiens | 2 | Detail |
Q9UI09 |
NDUFA12 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | Homo sapiens | 2 | Detail |
Q9NRX3 |
COXFA4L2 | Cytochrome c oxidase hypoxia associated subunit FA4L2 | Homo sapiens | 2 | Detail |
P22695 |
UQCRC2 | Cytochrome b-c1 complex subunit 2, mitochondrial | Homo sapiens | 2 | Detail |
P21796 |
VDAC1 | Non-selective voltage-gated ion channel VDAC1 | Homo sapiens | 2 | Detail |
Q9Y277 |
VDAC3 | Non-selective voltage-gated ion channel VDAC3 | Homo sapiens | 2 | Detail |
P78417 |
GSTO1 | Glutathione S-transferase omega-1 | Homo sapiens | 2 | Detail |
P13073 |
COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | Homo sapiens | 1 | Detail |
P12074 |
COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | Homo sapiens | 1 | Detail |
P09669 |
COX6C | Cytochrome c oxidase subunit 6C | Homo sapiens | 1 | Detail |
P09601 |
HMOX1 | Heme oxygenase 1 | Homo sapiens | 1 | Detail |
P25963 |
NFKBIA | NF-kappa-B inhibitor alpha | Homo sapiens | 1 | Detail |
P06576 |
ATP5F1B | ATP synthase F(1) complex subunit beta, mitochondrial | Homo sapiens | 1 | Detail |
P24539 |
ATP5PB | ATP synthase peripheral stalk subunit b, mitochondrial | Homo sapiens | 1 | Detail |
P48047 |
ATP5PO | ATP synthase peripheral stalk subunit OSCP, mitochondrial | Homo sapiens | 1 | Detail |
P31040 |
SDHA | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, m | Homo sapiens | 1 | Detail |
P31930 |
UQCRC1 | Cytochrome b-c1 complex subunit 1, mitochondrial | Homo sapiens | 1 | Detail |
P45880 |
VDAC2 | Non-selective voltage-gated ion channel VDAC2 | Homo sapiens | 1 | Detail |
P04040 |
CAT | Catalase | Homo sapiens | 1 | Detail |