Chemical carcinogenesis - receptor activation
hsa05207 122 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
O60674 |
JAK2 | Tyrosine-protein kinase JAK2 | Homo sapiens | 10545 | Detail |
P42336 |
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 5616 | Detail |
O00329 |
PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 3772 | Detail |
P00533 |
EGFR | Epidermal growth factor receptor | Homo sapiens | 3433 | Detail |
P27986 |
PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | Homo sapiens | 2553 | Detail |
P42345 |
MTOR | Serine/threonine-protein kinase mTOR | Homo sapiens | 2517 | Detail |
P04049 |
RAF1 | RAF proto-oncogene serine/threonine-protein kinase | Homo sapiens | 2133 | Detail |
P12931 |
SRC | Proto-oncogene tyrosine-protein kinase Src | Homo sapiens | 1978 | Detail |
P42338 |
PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 1951 | Detail |
P01116 |
KRAS | GTPase KRas | Homo sapiens | 1811 | Detail |
P24385 |
CCND1 | G1/S-specific cyclin-D1 | Homo sapiens | 1643 | Detail |
P31749 |
AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens | 1633 | Detail |
P03372 |
ESR1 | Estrogen receptor | Homo sapiens | 1446 | Detail |
Q92731 |
ESR2 | Estrogen receptor beta | Homo sapiens | 1440 | Detail |
P23443 |
RPS6KB1 | Ribosomal protein S6 kinase beta-1 | Homo sapiens | 1180 | Detail |
P10415 |
BCL2 | Apoptosis regulator Bcl-2 | Homo sapiens | 1065 | Detail |
P01111 |
NRAS | GTPase NRas | Homo sapiens | 923 | Detail |
P28482 |
MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens | 906 | Detail |
P98170 |
XIAP | E3 ubiquitin-protein ligase XIAP | Homo sapiens | 897 | Detail |
P31751 |
AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens | 896 | Detail |
P08684 |
CYP3A4 | Cytochrome P450 3A4 | Homo sapiens | 851 | Detail |
P17787 |
CHRNB2 | Neuronal acetylcholine receptor subunit beta-2 | Homo sapiens | 781 | Detail |
Q07889 |
SOS1 | Son of sevenless homolog 1 | Homo sapiens | 766 | Detail |
P43681 |
CHRNA4 | Neuronal acetylcholine receptor subunit alpha-4 | Homo sapiens | 755 | Detail |
P19793 |
RXRA | Retinoic acid receptor RXR-alpha | Homo sapiens | 702 | Detail |
P07550 |
ADRB2 | Beta-2 adrenergic receptor | Homo sapiens | 697 | Detail |
P17252 |
PRKCA | Protein kinase C alpha type | Homo sapiens | 679 | Detail |
P07900 |
HSP90AA1 | Heat shock protein HSP 90-alpha | Homo sapiens | 674 | Detail |
P30281 |
CCND3 | G1/S-specific cyclin-D3 | Homo sapiens | 656 | Detail |
P06401 |
PGR | Progesterone receptor | Homo sapiens | 617 | Detail |
P08238 |
HSP90AB1 | Heat shock protein HSP 90-beta | Homo sapiens | 602 | Detail |
Q14164 |
IKBKE | Inhibitor of nuclear factor kappa-B kinase subunit epsilon | Homo sapiens | 596 | Detail |
Q02750 |
MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens | 543 | Detail |
P08588 |
ADRB1 | Beta-1 adrenergic receptor | Homo sapiens | 541 | Detail |
P32297 |
CHRNA3 | Neuronal acetylcholine receptor subunit alpha-3 | Homo sapiens | 506 | Detail |
O00459 |
PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | Homo sapiens | 485 | Detail |
P41182 |
BCL6 | B-cell lymphoma 6 protein | Homo sapiens | 472 | Detail |
P05771 |
PRKCB | Protein kinase C beta type | Homo sapiens | 457 | Detail |
P17612 |
PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | Homo sapiens | 453 | Detail |
P30926 |
CHRNB4 | Neuronal acetylcholine receptor subunit beta-4 | Homo sapiens | 431 | Detail |
P05177 |
CYP1A2 | Cytochrome P450 1A2 | Homo sapiens | 386 | Detail |
P10275 |
AR | Androgen receptor | Homo sapiens | 364 | Detail |
Q13541 |
EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein | Homo sapiens | 358 | Detail |
Q07869 |
PPARA | Peroxisome proliferator-activated receptor alpha | Homo sapiens | 355 | Detail |
P51812 |
RPS6KA3 | Ribosomal protein S6 kinase alpha-3 | Homo sapiens | 322 | Detail |
Q9Y243 |
AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens | 321 | Detail |
Q16678 |
CYP1B1 | Cytochrome P450 1B1 | Homo sapiens | 315 | Detail |
P36544 |
CHRNA7 | Neuronal acetylcholine receptor subunit alpha-7 | Homo sapiens | 311 | Detail |
P04798 |
CYP1A1 | Cytochrome P450 1A1 | Homo sapiens | 311 | Detail |
P05129 |
PRKCG | Protein kinase C gamma type | Homo sapiens | 311 | Detail |
Q92569 |
PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | Homo sapiens | 289 | Detail |
P34913 |
EPHX2 | Bifunctional epoxide hydrolase 2 | Homo sapiens | 257 | Detail |
P13945 |
ADRB3 | Beta-3 adrenergic receptor | Homo sapiens | 254 | Detail |
P27361 |
MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens | 234 | Detail |
Q13936 |
CACNA1C | Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens | 147 | Detail |
P36507 |
MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | Homo sapiens | 146 | Detail |
Q15418 |
RPS6KA1 | Ribosomal protein S6 kinase alpha-1 | Homo sapiens | 144 | Detail |
P19838 |
NFKB1 | Nuclear factor NF-kappa-B p105 subunit | Homo sapiens | 140 | Detail |
Q04206 |
RELA | Transcription factor p65 | Homo sapiens | 134 | Detail |
P22694 |
PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Homo sapiens | 121 | Detail |
Q01668 |
CACNA1D | Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens | 117 | Detail |
O60840 |
CACNA1F | Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens | 117 | Detail |
Q13698 |
CACNA1S | Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens | 117 | Detail |
P07099 |
EPHX1 | Epoxide hydrolase 1 | Homo sapiens | 114 | Detail |
P22612 |
PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | Homo sapiens | 111 | Detail |
Q15349 |
RPS6KA2 | Ribosomal protein S6 kinase alpha-2 | Homo sapiens | 109 | Detail |
Q00975 |
CACNA1B | Voltage-dependent N-type calcium channel subunit alpha-1B | Homo sapiens | 96 | Detail |
P48443 |
RXRG | Retinoic acid receptor RXR-gamma | Homo sapiens | 94 | Detail |
P28702 |
RXRB | Retinoic acid receptor RXR-beta | Homo sapiens | 87 | Detail |
P11473 |
VDR | Vitamin D3 receptor | Homo sapiens | 87 | Detail |
Q9UGM1 |
CHRNA9 | Neuronal acetylcholine receptor subunit alpha-9 | Homo sapiens | 78 | Detail |
P09038 |
FGF2 | Fibroblast growth factor 2 | Homo sapiens | 69 | Detail |
P05412 |
JUN | Transcription factor Jun | Homo sapiens | 69 | Detail |
P14625 |
HSP90B1 | Endoplasmin | Homo sapiens | 67 | Detail |
Q9UK32 |
RPS6KA6 | Ribosomal protein S6 kinase alpha-6 | Homo sapiens | 53 | Detail |
P40763 |
STAT3 | Signal transducer and activator of transcription 3 | Homo sapiens | 49 | Detail |
O00555 |
CACNA1A | Voltage-dependent P/Q-type calcium channel subunit alpha-1A | Homo sapiens | 45 | Detail |
P15692 |
VEGFA | Vascular endothelial growth factor A, long form | Homo sapiens | 44 | Detail |
Q08828 |
ADCY1 | Adenylate cyclase type 1 | Homo sapiens | 30 | Detail |
P27540 |
ARNT | Aryl hydrocarbon receptor nuclear translocator | Homo sapiens | 30 | Detail |
P04628 |
WNT1 | Proto-oncogene Wnt-1 | Homo sapiens | 30 | Detail |
P28161 |
GSTM2 | Glutathione S-transferase Mu 2 | Homo sapiens | 28 | Detail |
P40145 |
ADCY8 | Adenylate cyclase type 8 | Homo sapiens | 27 | Detail |
Q92934 |
BAD | Bcl2-associated agonist of cell death | Homo sapiens | 27 | Detail |
P01100 |
FOS | Protein c-Fos | Homo sapiens | 25 | Detail |
O95622 |
ADCY5 | Adenylate cyclase type 5 | Homo sapiens | 23 | Detail |
P20813 |
CYP2B6 | Cytochrome P450 2B6 | Homo sapiens | 22 | Detail |
Q08462 |
ADCY2 | Adenylate cyclase type 2 | Homo sapiens | 21 | Detail |
O60266 |
ADCY3 | Adenylate cyclase type 3 | Homo sapiens | 21 | Detail |
O43306 |
ADCY6 | Adenylate cyclase type 6 | Homo sapiens | 21 | Detail |
P51828 |
ADCY7 | Adenylate cyclase type 7 | Homo sapiens | 21 | Detail |
O60503 |
ADCY9 | Adenylate cyclase type 9 | Homo sapiens | 21 | Detail |
Q8NFM4 |
ADCY4 | Adenylate cyclase type 4 | Homo sapiens | 21 | Detail |
P01106 |
MYC | Myc proto-oncogene protein | Homo sapiens | 19 | Detail |
P01112 |
HRAS | GTPase HRas | Homo sapiens | 14 | Detail |
Q9UBS0 |
RPS6KB2 | Ribosomal protein S6 kinase beta-2 | Homo sapiens | 13 | Detail |
P42229 |
STAT5A | Signal transducer and activator of transcription 5A | Homo sapiens | 11 | Detail |
P08263 |
GSTA1 | Glutathione S-transferase A1 | Homo sapiens | 9 | Detail |
Q13887 |
KLF5 | Krueppel-like factor 5 | Homo sapiens | 9 | Detail |
P06400 |
RB1 | Retinoblastoma-associated protein | Homo sapiens | 8 | Detail |
P35869 |
AHR | Aryl hydrocarbon receptor | Homo sapiens | 5 | Detail |
P51692 |
STAT5B | Signal transducer and activator of transcription 5B | Homo sapiens | 5 | Detail |
P30304 |
CDC25A | M-phase inducer phosphatase 1 | Homo sapiens | 5 | Detail |
P62993 |
GRB2 | Growth factor receptor-bound protein 2 | Homo sapiens | 4 | Detail |
P04899 |
GNAI2 | Guanine nucleotide-binding protein G(i) subunit alpha-2 | Homo sapiens | 3 | Detail |
P22309 |
UGT1A1 | UDP-glucuronosyltransferase 1A1 | Homo sapiens | 3 | Detail |
Q14994 |
NR1I3 | Nuclear receptor subfamily 1 group I member 3 | Homo sapiens | 3 | Detail |
P08754 |
GNAI3 | Guanine nucleotide-binding protein G(i) subunit alpha-3 | Homo sapiens | 2 | Detail |
P09210 |
GSTA2 | Glutathione S-transferase A2 | Homo sapiens | 2 | Detail |
P52292 |
KPNA2 | Importin subunit alpha-1 | Homo sapiens | 2 | Detail |
P78417 |
GSTO1 | Glutathione S-transferase omega-1 | Homo sapiens | 2 | Detail |
O60684 |
KPNA6 | Importin subunit alpha-7 | Homo sapiens | 1 | Detail |
P52294 |
KPNA1 | Importin subunit alpha-5 | Homo sapiens | 1 | Detail |
Q14974 |
KPNB1 | Importin subunit beta-1 | Homo sapiens | 1 | Detail |
O00505 |
KPNA3 | Importin subunit alpha-4 | Homo sapiens | 1 | Detail |
O00629 |
KPNA4 | Importin subunit alpha-3 | Homo sapiens | 1 | Detail |
P49407 |
ARRB1 | Beta-arrestin-1 | Homo sapiens | 1 | Detail |
Q04721 |
NOTCH2 | Neurogenic locus notch homolog protein 2 | Homo sapiens | 1 | Detail |
P19224 |
UGT1A6 | UDP-glucuronosyltransferase 1A6 | Homo sapiens | 1 | Detail |
P16662 |
UGT2B7 | UDP-glucuronosyltransferase 2B7 | Homo sapiens | 1 | Detail |
O14788 |
TNFSF11 | Tumor necrosis factor ligand superfamily member 11 | Homo sapiens | 1 | Detail |
O00170 |
AIP | AH receptor-interacting protein | Homo sapiens | 1 | Detail |