Proteoglycans in cancer
hsa05205 123 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
P35968 |
KDR | Vascular endothelial growth factor receptor 2 | Homo sapiens | 5667 | Detail |
P42336 |
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 5616 | Detail |
O00329 |
PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 3772 | Detail |
P00533 |
EGFR | Epidermal growth factor receptor | Homo sapiens | 3433 | Detail |
P11362 |
FGFR1 | Fibroblast growth factor receptor 1 | Homo sapiens | 3320 | Detail |
P08253 |
MMP2 | 72 kDa type IV collagenase | Homo sapiens | 2719 | Detail |
P15056 |
BRAF | Serine/threonine-protein kinase B-raf | Homo sapiens | 2643 | Detail |
P27986 |
PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | Homo sapiens | 2553 | Detail |
P42345 |
MTOR | Serine/threonine-protein kinase mTOR | Homo sapiens | 2517 | Detail |
P05106 |
ITGB3 | Integrin beta-3 | Homo sapiens | 2474 | Detail |
P04049 |
RAF1 | RAF proto-oncogene serine/threonine-protein kinase | Homo sapiens | 2133 | Detail |
P04626 |
ERBB2 | Receptor tyrosine-protein kinase erbB-2 | Homo sapiens | 2123 | Detail |
P12931 |
SRC | Proto-oncogene tyrosine-protein kinase Src | Homo sapiens | 1978 | Detail |
P42338 |
PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 1951 | Detail |
P14780 |
MMP9 | Matrix metalloproteinase-9 | Homo sapiens | 1941 | Detail |
P01116 |
KRAS | GTPase KRas | Homo sapiens | 1811 | Detail |
Q16539 |
MAPK14 | Mitogen-activated protein kinase 14 | Homo sapiens | 1754 | Detail |
O75116 |
ROCK2 | Rho-associated protein kinase 2 | Homo sapiens | 1696 | Detail |
P24385 |
CCND1 | G1/S-specific cyclin-D1 | Homo sapiens | 1643 | Detail |
P31749 |
AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens | 1633 | Detail |
P06756 |
ITGAV | Integrin alpha-V | Homo sapiens | 1632 | Detail |
Q13464 |
ROCK1 | Rho-associated protein kinase 1 | Homo sapiens | 1614 | Detail |
P05556 |
ITGB1 | Integrin beta-1 | Homo sapiens | 1572 | Detail |
P03372 |
ESR1 | Estrogen receptor | Homo sapiens | 1446 | Detail |
Q00987 |
MDM2 | E3 ubiquitin-protein ligase Mdm2 | Homo sapiens | 1334 | Detail |
P23443 |
RPS6KB1 | Ribosomal protein S6 kinase beta-1 | Homo sapiens | 1180 | Detail |
P04637 |
TP53 | Cellular tumor antigen p53 | Homo sapiens | 1173 | Detail |
P08581 |
MET | Hepatocyte growth factor receptor | Homo sapiens | 1125 | Detail |
P07711 |
CTSL | Procathepsin L | Homo sapiens | 975 | Detail |
P01111 |
NRAS | GTPase NRas | Homo sapiens | 923 | Detail |
P28482 |
MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens | 906 | Detail |
P31751 |
AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens | 896 | Detail |
Q07889 |
SOS1 | Son of sevenless homolog 1 | Homo sapiens | 766 | Detail |
P17252 |
PRKCA | Protein kinase C alpha type | Homo sapiens | 679 | Detail |
P08069 |
IGF1R | Insulin-like growth factor 1 receptor | Homo sapiens | 611 | Detail |
P53778 |
MAPK12 | Mitogen-activated protein kinase 12 | Homo sapiens | 606 | Detail |
Q15759 |
MAPK11 | Mitogen-activated protein kinase 11 | Homo sapiens | 594 | Detail |
Q02750 |
MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens | 543 | Detail |
O15264 |
MAPK13 | Mitogen-activated protein kinase 13 | Homo sapiens | 533 | Detail |
O00459 |
PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | Homo sapiens | 485 | Detail |
P05771 |
PRKCB | Protein kinase C beta type | Homo sapiens | 457 | Detail |
P17612 |
PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | Homo sapiens | 453 | Detail |
P42574 |
CASP3 | Caspase-3 | Homo sapiens | 444 | Detail |
P18084 |
ITGB5 | Integrin beta-5 | Homo sapiens | 402 | Detail |
P08648 |
ITGA5 | Integrin alpha-5 | Homo sapiens | 366 | Detail |
Q15303 |
ERBB4 | Receptor tyrosine-protein kinase erbB-4 | Homo sapiens | 336 | Detail |
Q05397 |
PTK2 | Focal adhesion kinase 1 | Homo sapiens | 325 | Detail |
Q9Y243 |
AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens | 321 | Detail |
P05129 |
PRKCG | Protein kinase C gamma type | Homo sapiens | 311 | Detail |
Q92569 |
PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | Homo sapiens | 289 | Detail |
P00749 |
PLAU | Urokinase-type plasminogen activator | Homo sapiens | 256 | Detail |
P27361 |
MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens | 234 | Detail |
O15530 |
PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | Homo sapiens | 228 | Detail |
Q06124 |
PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | Homo sapiens | 214 | Detail |
P35222 |
CTNNB1 | Catenin beta-1 | Homo sapiens | 176 | Detail |
Q13557 |
CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 150 | Detail |
P36507 |
MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | Homo sapiens | 146 | Detail |
P01375 |
TNF | Tumor necrosis factor | Homo sapiens | 144 | Detail |
Q13555 |
CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 123 | Detail |
P22694 |
PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Homo sapiens | 121 | Detail |
P22612 |
PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | Homo sapiens | 111 | Detail |
P21860 |
ERBB3 | Receptor tyrosine-protein kinase erbB-3 | Homo sapiens | 109 | Detail |
Q13153 |
PAK1 | Serine/threonine-protein kinase PAK 1 | Homo sapiens | 107 | Detail |
Q16665 |
HIF1A | Hypoxia-inducible factor 1-alpha | Homo sapiens | 81 | Detail |
Q9UQM7 |
CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 75 | Detail |
P09038 |
FGF2 | Fibroblast growth factor 2 | Homo sapiens | 69 | Detail |
Q13554 |
CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 68 | Detail |
P17301 |
ITGA2 | Integrin alpha-2 | Homo sapiens | 65 | Detail |
P40763 |
STAT3 | Signal transducer and activator of transcription 3 | Homo sapiens | 49 | Detail |
P15692 |
VEGFA | Vascular endothelial growth factor A, long form | Homo sapiens | 44 | Detail |
P10398 |
ARAF | Serine/threonine-protein kinase A-Raf | Homo sapiens | 37 | Detail |
Q9Y251 |
HPSE | Heparanase | Homo sapiens | 35 | Detail |
P04628 |
WNT1 | Proto-oncogene Wnt-1 | Homo sapiens | 30 | Detail |
Q99835 |
SMO | Protein smoothened | Homo sapiens | 20 | Detail |
P56704 |
WNT3A | Protein Wnt-3a | Homo sapiens | 20 | Detail |
P01106 |
MYC | Myc proto-oncogene protein | Homo sapiens | 19 | Detail |
P22681 |
CBL | E3 ubiquitin-protein ligase CBL | Homo sapiens | 16 | Detail |
P60953 |
CDC42 | Cell division control protein 42 homolog | Homo sapiens | 16 | Detail |
P01112 |
HRAS | GTPase HRas | Homo sapiens | 14 | Detail |
O60603 |
TLR2 | Toll-like receptor 2 | Homo sapiens | 14 | Detail |
P62753 |
RPS6 | Small ribosomal subunit protein eS6 | Homo sapiens | 13 | Detail |
Q9UBS0 |
RPS6KB2 | Ribosomal protein S6 kinase beta-2 | Homo sapiens | 13 | Detail |
P29350 |
PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | Homo sapiens | 12 | Detail |
Q15796 |
SMAD2 | SMAD family member 2 | Homo sapiens | 10 | Detail |
P19634 |
SLC9A1 | Sodium/hydrogen exchanger 1 | Homo sapiens | 10 | Detail |
O00206 |
TLR4 | Toll-like receptor 4 | Homo sapiens | 9 | Detail |
P01137 |
TGFB1 | Transforming growth factor beta-1 proprotein | Homo sapiens | 8 | Detail |
P36873 |
PPP1CC | Serine/threonine-protein phosphatase PP1-gamma catalytic sub | Homo sapiens | 5 | Detail |
P62993 |
GRB2 | Growth factor receptor-bound protein 2 | Homo sapiens | 4 | Detail |
P14210 |
HGF | Hepatocyte growth factor | Homo sapiens | 4 | Detail |
Q14643 |
ITPR1 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 | Homo sapiens | 4 | Detail |
Q14573 |
ITPR3 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 | Homo sapiens | 4 | Detail |
Q03405 |
PLAUR | Urokinase plasminogen activator surface receptor | Homo sapiens | 4 | Detail |
Q15465 |
SHH | Sonic hedgehog protein | Homo sapiens | 4 | Detail |
Q9UP38 |
FZD1 | Frizzled-1 | Homo sapiens | 4 | Detail |
P17844 |
DDX5 | Probable ATP-dependent RNA helicase DDX5 | Homo sapiens | 3 | Detail |
P02751 |
FN1 | Fibronectin | Homo sapiens | 3 | Detail |
Q14571 |
ITPR2 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 | Homo sapiens | 3 | Detail |
P63000 |
RAC1 | Ras-related C3 botulinum toxin substrate 1 | Homo sapiens | 3 | Detail |
O75084 |
FZD7 | Frizzled-7 | Homo sapiens | 3 | Detail |
P08962 |
CD63 | CD63 antigen | Homo sapiens | 3 | Detail |
P23588 |
EIF4B | Eukaryotic translation initiation factor 4B | Homo sapiens | 2 | Detail |
Q13480 |
GAB1 | GRB2-associated-binding protein 1 | Homo sapiens | 2 | Detail |
P19174 |
PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase ga | Homo sapiens | 2 | Detail |
P16885 |
PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase ga | Homo sapiens | 2 | Detail |
P62136 |
PPP1CA | Serine/threonine-protein phosphatase PP1-alpha catalytic sub | Homo sapiens | 2 | Detail |
P34741 |
SDC2 | Syndecan-2 | Homo sapiens | 2 | Detail |
P31431 |
SDC4 | Syndecan-4 | Homo sapiens | 2 | Detail |
P61812 |
TGFB2 | Transforming growth factor beta-2 proprotein | Homo sapiens | 2 | Detail |
P46940 |
IQGAP1 | Ras GTPase-activating-like protein IQGAP1 | Homo sapiens | 2 | Detail |
P38936 |
CDKN1A | Cyclin-dependent kinase inhibitor 1 | Homo sapiens | 1 | Detail |
Q8WU20 |
FRS2 | Fibroblast growth factor receptor substrate 2 | Homo sapiens | 1 | Detail |
Q14247 |
CTTN | Src substrate cortactin | Homo sapiens | 1 | Detail |
P21333 |
FLNA | Filamin-A | Homo sapiens | 1 | Detail |
Q14332 |
FZD2 | Frizzled-2 | Homo sapiens | 1 | Detail |
Q53EL6 |
PDCD4 | Programmed cell death protein 4 | Homo sapiens | 1 | Detail |
P14317 |
HCLS1 | Hematopoietic lineage cell-specific protein | Homo sapiens | 1 | Detail |
P26038 |
MSN | Moesin | Homo sapiens | 1 | Detail |
P35241 |
RDX | Radixin | Homo sapiens | 1 | Detail |
P18827 |
SDC1 | Syndecan-1 | Homo sapiens | 1 | Detail |
P35625 |
TIMP3 | Metalloproteinase inhibitor 3 | Homo sapiens | 1 | Detail |
P15498 |
VAV1 | Proto-oncogene vav | Homo sapiens | 1 | Detail |
P15311 |
EZR | Ezrin | Homo sapiens | 1 | Detail |