Shigellosis
hsa05131 123 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
P42336 |
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 5616 | Detail |
O00329 |
PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 3772 | Detail |
P00533 |
EGFR | Epidermal growth factor receptor | Homo sapiens | 3433 | Detail |
P27986 |
PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | Homo sapiens | 2553 | Detail |
P42345 |
MTOR | Serine/threonine-protein kinase mTOR | Homo sapiens | 2517 | Detail |
P49841 |
GSK3B | Glycogen synthase kinase-3 beta | Homo sapiens | 2206 | Detail |
P12931 |
SRC | Proto-oncogene tyrosine-protein kinase Src | Homo sapiens | 1978 | Detail |
P42338 |
PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 1951 | Detail |
Q16539 |
MAPK14 | Mitogen-activated protein kinase 14 | Homo sapiens | 1754 | Detail |
O75116 |
ROCK2 | Rho-associated protein kinase 2 | Homo sapiens | 1696 | Detail |
P31749 |
AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens | 1633 | Detail |
Q13464 |
ROCK1 | Rho-associated protein kinase 1 | Homo sapiens | 1614 | Detail |
P05556 |
ITGB1 | Integrin beta-1 | Homo sapiens | 1572 | Detail |
Q00987 |
MDM2 | E3 ubiquitin-protein ligase Mdm2 | Homo sapiens | 1334 | Detail |
P49840 |
GSK3A | Glycogen synthase kinase-3 alpha | Homo sapiens | 1262 | Detail |
P23443 |
RPS6KB1 | Ribosomal protein S6 kinase beta-1 | Homo sapiens | 1180 | Detail |
P04637 |
TP53 | Cellular tumor antigen p53 | Homo sapiens | 1173 | Detail |
P10415 |
BCL2 | Apoptosis regulator Bcl-2 | Homo sapiens | 1065 | Detail |
Q07817 |
BCL2L1 | Bcl-2-like protein 1 | Homo sapiens | 990 | Detail |
P28482 |
MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens | 906 | Detail |
P31751 |
AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens | 896 | Detail |
Q04759 |
PRKCQ | Protein kinase C theta type | Homo sapiens | 750 | Detail |
P45983 |
MAPK8 | Mitogen-activated protein kinase 8 | Homo sapiens | 748 | Detail |
Q05655 |
PRKCD | Protein kinase C delta type | Homo sapiens | 742 | Detail |
P45984 |
MAPK9 | Mitogen-activated protein kinase 9 | Homo sapiens | 676 | Detail |
Q9UHD2 |
TBK1 | Serine/threonine-protein kinase TBK1 | Homo sapiens | 639 | Detail |
P53779 |
MAPK10 | Mitogen-activated protein kinase 10 | Homo sapiens | 625 | Detail |
P53778 |
MAPK12 | Mitogen-activated protein kinase 12 | Homo sapiens | 606 | Detail |
Q15759 |
MAPK11 | Mitogen-activated protein kinase 11 | Homo sapiens | 594 | Detail |
O15264 |
MAPK13 | Mitogen-activated protein kinase 13 | Homo sapiens | 533 | Detail |
O00459 |
PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | Homo sapiens | 485 | Detail |
Q02156 |
PRKCE | Protein kinase C epsilon type | Homo sapiens | 423 | Detail |
O14920 |
IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | Homo sapiens | 411 | Detail |
P08648 |
ITGA5 | Integrin alpha-5 | Homo sapiens | 366 | Detail |
Q05397 |
PTK2 | Focal adhesion kinase 1 | Homo sapiens | 325 | Detail |
Q9Y243 |
AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens | 321 | Detail |
Q13546 |
RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | Homo sapiens | 315 | Detail |
Q92569 |
PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | Homo sapiens | 289 | Detail |
P27361 |
MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens | 234 | Detail |
O43353 |
RIPK2 | Receptor-interacting serine/threonine-protein kinase 2 | Homo sapiens | 210 | Detail |
Q8N122 |
RPTOR | Regulatory-associated protein of mTOR | Homo sapiens | 189 | Detail |
O43318 |
MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | Homo sapiens | 178 | Detail |
P29466 |
CASP1 | Caspase-1 | Homo sapiens | 173 | Detail |
O15111 |
CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | Homo sapiens | 170 | Detail |
Q13315 |
ATM | Serine-protein kinase ATM | Homo sapiens | 170 | Detail |
P07384 |
CAPN1 | Calpain-1 catalytic subunit | Homo sapiens | 168 | Detail |
O75582 |
RPS6KA5 | Ribosomal protein S6 kinase alpha-5 | Homo sapiens | 157 | Detail |
P01584 |
IL1B | Interleukin-1 beta | Homo sapiens | 148 | Detail |
P01375 |
TNF | Tumor necrosis factor | Homo sapiens | 144 | Detail |
P19838 |
NFKB1 | Nuclear factor NF-kappa-B p105 subunit | Homo sapiens | 140 | Detail |
Q04206 |
RELA | Transcription factor p65 | Homo sapiens | 134 | Detail |
P17655 |
CAPN2 | Calpain-2 catalytic subunit | Homo sapiens | 114 | Detail |
Q15750 |
TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | Homo sapiens | 97 | Detail |
Q8NEB9 |
PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3 | Homo sapiens | 93 | Detail |
P05412 |
JUN | Transcription factor Jun | Homo sapiens | 69 | Detail |
P04632 |
CAPNS1 | Calpain small subunit 1 | Homo sapiens | 56 | Detail |
Q9Y239 |
NOD1 | Nucleotide-binding oligomerization domain-containing protein | Homo sapiens | 43 | Detail |
P49662 |
CASP4 | Caspase-4 | Homo sapiens | 29 | Detail |
Q96B36 |
AKT1S1 | Proline-rich AKT1 substrate 1 | Homo sapiens | 22 | Detail |
Q96P20 |
NLRP3 | NACHT, LRR and PYD domains-containing protein 3 | Homo sapiens | 16 | Detail |
P60953 |
CDC42 | Cell division control protein 42 homolog | Homo sapiens | 16 | Detail |
P62330 |
ARF6 | ADP-ribosylation factor 6 | Homo sapiens | 14 | Detail |
Q9UBS0 |
RPS6KB2 | Ribosomal protein S6 kinase beta-2 | Homo sapiens | 13 | Detail |
Q9Y6K9 |
IKBKG | NF-kappa-B essential modulator | Homo sapiens | 13 | Detail |
P19367 |
HK1 | Hexokinase-1 | Homo sapiens | 12 | Detail |
P62979 |
RPS27A | Ubiquitin-ribosomal protein eS31 fusion protein | Homo sapiens | 12 | Detail |
P13501 |
CCL5 | C-C motif chemokine 5 | Homo sapiens | 12 | Detail |
P52789 |
HK2 | Hexokinase-2 | Homo sapiens | 11 | Detail |
Q9UDY8 |
MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation pro | Homo sapiens | 10 | Detail |
P10145 |
CXCL8 | Interleukin-8 | Homo sapiens | 9 | Detail |
O00206 |
TLR4 | Toll-like receptor 4 | Homo sapiens | 9 | Detail |
Q14457 |
BECN1 | Beclin-1 | Homo sapiens | 7 | Detail |
Q9GZQ8 |
MAP1LC3B | Microtubule-associated protein 1 light chain 3 beta | Homo sapiens | 6 | Detail |
Q9UHD8 |
SEPTIN9 | Septin-9 | Homo sapiens | 4 | Detail |
P04141 |
CSF2 | Granulocyte-macrophage colony-stimulating factor | Homo sapiens | 4 | Detail |
Q14643 |
ITPR1 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 | Homo sapiens | 4 | Detail |
Q14573 |
ITPR3 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 | Homo sapiens | 4 | Detail |
Q01081 |
U2AF1 | Splicing factor U2AF 35 kDa subunit | Homo sapiens | 3 | Detail |
Q13418 |
ILK | Scaffold protein ILK | Homo sapiens | 3 | Detail |
Q14571 |
ITPR2 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 | Homo sapiens | 3 | Detail |
Q08752 |
PPID | Peptidyl-prolyl cis-trans isomerase D | Homo sapiens | 3 | Detail |
P63000 |
RAC1 | Ras-related C3 botulinum toxin substrate 1 | Homo sapiens | 3 | Detail |
P68431 |
H3C1 | Histone H3.1 | Homo sapiens | 3 | Detail |
P61158 |
ACTR3 | Actin-related protein 3 | Homo sapiens | 2 | Detail |
P61160 |
ACTR2 | Actin-related protein 2 | Homo sapiens | 2 | Detail |
Q8N884 |
CGAS | Cyclic GMP-AMP synthase | Homo sapiens | 2 | Detail |
P19174 |
PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase ga | Homo sapiens | 2 | Detail |
P16885 |
PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase ga | Homo sapiens | 2 | Detail |
P19438 |
TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A | Homo sapiens | 2 | Detail |
P61088 |
UBE2N | Ubiquitin-conjugating enzyme E2 N | Homo sapiens | 2 | Detail |
Q13404 |
UBE2V1 | Ubiquitin-conjugating enzyme E2 variant 1 | Homo sapiens | 2 | Detail |
P21796 |
VDAC1 | Non-selective voltage-gated ion channel VDAC1 | Homo sapiens | 2 | Detail |
O43707 |
ACTN4 | Alpha-actinin-4 | Homo sapiens | 2 | Detail |
Q13616 |
CUL1 | Cullin-1 | Homo sapiens | 2 | Detail |
Q92974 |
ARHGEF2 | Rho guanine nucleotide exchange factor 2 | Homo sapiens | 2 | Detail |
P08571 |
CD14 | Monocyte differentiation antigen CD14 | Homo sapiens | 2 | Detail |
O15145 |
ARPC3 | Actin-related protein 2/3 complex subunit 3 | Homo sapiens | 1 | Detail |
O15143 |
ARPC1B | Actin-related protein 2/3 complex subunit 1B | Homo sapiens | 1 | Detail |
O15144 |
ARPC2 | Actin-related protein 2/3 complex subunit 2 | Homo sapiens | 1 | Detail |
Q13137 |
CALCOCO2 | Calcium-binding and coiled-coil domain-containing protein 2 | Homo sapiens | 1 | Detail |
Q9BYM8 |
RBCK1 | RanBP-type and C3HC4-type zinc finger-containing protein 1 | Homo sapiens | 1 | Detail |
Q13185 |
CBX3 | Chromobox protein homolog 3 | Homo sapiens | 1 | Detail |
P46109 |
CRKL | Crk-like protein | Homo sapiens | 1 | Detail |
O60610 |
DIAPH1 | Protein diaphanous homolog 1 | Homo sapiens | 1 | Detail |
Q14247 |
CTTN | Src substrate cortactin | Homo sapiens | 1 | Detail |
P14317 |
HCLS1 | Hematopoietic lineage cell-specific protein | Homo sapiens | 1 | Detail |
Q99570 |
PIK3R4 | Phosphoinositide 3-kinase regulatory subunit 4 | Homo sapiens | 1 | Detail |
Q86WV6 |
STING1 | Stimulator of interferon genes protein | Homo sapiens | 1 | Detail |
P14778 |
IL1R1 | Interleukin-1 receptor type 1 | Homo sapiens | 1 | Detail |
P25963 |
NFKBIA | NF-kappa-B inhibitor alpha | Homo sapiens | 1 | Detail |
P99999 |
CYCS | Cytochrome c | Homo sapiens | 1 | Detail |
Q96EP0 |
RNF31 | E3 ubiquitin-protein ligase RNF31 | Homo sapiens | 1 | Detail |
Q07812 |
BAX | Apoptosis regulator BAX | Homo sapiens | 1 | Detail |
P63208 |
SKP1 | S-phase kinase-associated protein 1 | Homo sapiens | 1 | Detail |
Q9Y490 |
TLN1 | Talin-1 | Homo sapiens | 1 | Detail |
Q12933 |
TRAF2 | TNF receptor-associated factor 2 | Homo sapiens | 1 | Detail |
P18206 |
VCL | Vinculin | Homo sapiens | 1 | Detail |
Q9H0F6 |
SHARPIN | Sharpin | Homo sapiens | 1 | Detail |
Q9BPX5 |
ARPC5L | Actin-related protein 2/3 complex subunit 5-like protein | Homo sapiens | 1 | Detail |
Q9H492 |
MAP1LC3A | Microtubule-associated protein 1 light chain 3 alpha | Homo sapiens | 1 | Detail |
P12814 |
ACTN1 | Alpha-actinin-1 | Homo sapiens | 1 | Detail |
Q13501 |
SQSTM1 | Sequestosome-1 | Homo sapiens | 1 | Detail |
P51178 |
PLCD1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase de | Homo sapiens | 0 | Detail |