Morphine addiction
hsa05032 70 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
P18505 |
GABRB1 | Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens | 5316 | Detail |
P35372 |
OPRM1 | Mu-type opioid receptor | Homo sapiens | 4568 | Detail |
P30542 |
ADORA1 | Adenosine receptor A1 | Homo sapiens | 3399 | Detail |
Q07343 |
PDE4B | 3',5'-cyclic-AMP phosphodiesterase 4B | Homo sapiens | 1901 | Detail |
Q08499 |
PDE4D | 3',5'-cyclic-AMP phosphodiesterase 4D | Homo sapiens | 1509 | Detail |
P14867 |
GABRA1 | Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens | 1420 | Detail |
P27815 |
PDE4A | 3',5'-cyclic-AMP phosphodiesterase 4A | Homo sapiens | 1354 | Detail |
P31644 |
GABRA5 | Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens | 1276 | Detail |
P18507 |
GABRG2 | Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens | 1275 | Detail |
Q08493 |
PDE4C | 3',5'-cyclic-AMP phosphodiesterase 4C | Homo sapiens | 1225 | Detail |
P28472 |
GABRB3 | Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens | 1198 | Detail |
P34903 |
GABRA3 | Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens | 1007 | Detail |
Q14432 |
PDE3A | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A | Homo sapiens | 995 | Detail |
Q13370 |
PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B | Homo sapiens | 936 | Detail |
P47869 |
GABRA2 | Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens | 901 | Detail |
P21728 |
DRD1 | D(1A) dopamine receptor | Homo sapiens | 738 | Detail |
P17252 |
PRKCA | Protein kinase C alpha type | Homo sapiens | 679 | Detail |
Q01064 |
PDE1B | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic n | Homo sapiens | 652 | Detail |
Q14123 |
PDE1C | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic n | Homo sapiens | 637 | Detail |
P54750 |
PDE1A | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic n | Homo sapiens | 624 | Detail |
Q8N1C3 |
GABRG1 | Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens | 485 | Detail |
P05771 |
PRKCB | Protein kinase C beta type | Homo sapiens | 457 | Detail |
P17612 |
PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | Homo sapiens | 453 | Detail |
P47870 |
GABRB2 | Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens | 445 | Detail |
Q16445 |
GABRA6 | Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens | 398 | Detail |
P48169 |
GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens | 364 | Detail |
Q9Y233 |
PDE10A | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase | Homo sapiens | 348 | Detail |
O14764 |
GABRD | Gamma-aminobutyric acid receptor subunit delta | Homo sapiens | 327 | Detail |
Q99928 |
GABRG3 | Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens | 326 | Detail |
P78334 |
GABRE | Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens | 325 | Detail |
O00591 |
GABRP | Gamma-aminobutyric acid receptor subunit pi | Homo sapiens | 325 | Detail |
Q9UN88 |
GABRQ | Gamma-aminobutyric acid receptor subunit theta | Homo sapiens | 325 | Detail |
P05129 |
PRKCG | Protein kinase C gamma type | Homo sapiens | 311 | Detail |
O00408 |
PDE2A | cGMP-dependent 3',5'-cyclic phosphodiesterase | Homo sapiens | 293 | Detail |
Q13946 |
PDE7A | High affinity 3',5'-cyclic-AMP phosphodiesterase 7A | Homo sapiens | 157 | Detail |
P48549 |
KCNJ3 | G protein-activated inward rectifier potassium channel 1 | Homo sapiens | 143 | Detail |
P25098 |
GRK2 | Beta-adrenergic receptor kinase 1 | Homo sapiens | 141 | Detail |
P48544 |
KCNJ5 | G protein-activated inward rectifier potassium channel 4 | Homo sapiens | 140 | Detail |
P22694 |
PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Homo sapiens | 121 | Detail |
P22612 |
PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | Homo sapiens | 111 | Detail |
Q00975 |
CACNA1B | Voltage-dependent N-type calcium channel subunit alpha-1B | Homo sapiens | 96 | Detail |
Q9NP56 |
PDE7B | 3',5'-cyclic-AMP phosphodiesterase 7B | Homo sapiens | 83 | Detail |
P34947 |
GRK5 | G protein-coupled receptor kinase 5 | Homo sapiens | 71 | Detail |
O00555 |
CACNA1A | Voltage-dependent P/Q-type calcium channel subunit alpha-1A | Homo sapiens | 45 | Detail |
P35626 |
GRK3 | G protein-coupled receptor kinase 3 | Homo sapiens | 35 | Detail |
Q9HCR9 |
PDE11A | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | Homo sapiens | 35 | Detail |
Q08828 |
ADCY1 | Adenylate cyclase type 1 | Homo sapiens | 30 | Detail |
P40145 |
ADCY8 | Adenylate cyclase type 8 | Homo sapiens | 27 | Detail |
Q9UBS5 |
GABBR1 | Gamma-aminobutyric acid type B receptor subunit 1 | Homo sapiens | 27 | Detail |
O75899 |
GABBR2 | Gamma-aminobutyric acid type B receptor subunit 2 | Homo sapiens | 26 | Detail |
O60658 |
PDE8A | High affinity cAMP-specific and IBMX-insensitive 3',5'-cycli | Homo sapiens | 25 | Detail |
O95622 |
ADCY5 | Adenylate cyclase type 5 | Homo sapiens | 23 | Detail |
P32298 |
GRK4 | G protein-coupled receptor kinase 4 | Homo sapiens | 22 | Detail |
Q08462 |
ADCY2 | Adenylate cyclase type 2 | Homo sapiens | 21 | Detail |
O60266 |
ADCY3 | Adenylate cyclase type 3 | Homo sapiens | 21 | Detail |
O43306 |
ADCY6 | Adenylate cyclase type 6 | Homo sapiens | 21 | Detail |
P51828 |
ADCY7 | Adenylate cyclase type 7 | Homo sapiens | 21 | Detail |
O60503 |
ADCY9 | Adenylate cyclase type 9 | Homo sapiens | 21 | Detail |
Q8NFM4 |
ADCY4 | Adenylate cyclase type 4 | Homo sapiens | 21 | Detail |
P43250 |
GRK6 | G protein-coupled receptor kinase 6 | Homo sapiens | 19 | Detail |
O95263 |
PDE8B | High affinity cAMP-specific and IBMX-insensitive 3',5'-cycli | Homo sapiens | 16 | Detail |
P48051 |
KCNJ6 | G protein-activated inward rectifier potassium channel 2 | Homo sapiens | 15 | Detail |
A8MPY1 |
GABRR3 | Gamma-aminobutyric acid receptor subunit rho-3 | Homo sapiens | 3 | Detail |
P24046 |
GABRR1 | Gamma-aminobutyric acid receptor subunit rho-1 | Homo sapiens | 3 | Detail |
P04899 |
GNAI2 | Guanine nucleotide-binding protein G(i) subunit alpha-2 | Homo sapiens | 3 | Detail |
P08754 |
GNAI3 | Guanine nucleotide-binding protein G(i) subunit alpha-3 | Homo sapiens | 2 | Detail |
P62873 |
GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit be | Homo sapiens | 2 | Detail |
P59768 |
GNG2 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit ga | Homo sapiens | 2 | Detail |
P28476 |
GABRR2 | Gamma-aminobutyric acid receptor subunit rho-2 | Homo sapiens | 1 | Detail |
P49407 |
ARRB1 | Beta-arrestin-1 | Homo sapiens | 1 | Detail |