Prion disease
hsa05020 190 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
P42336 |
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 5616 | Detail |
O00329 |
PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 3772 | Detail |
P27986 |
PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | Homo sapiens | 2553 | Detail |
P49841 |
GSK3B | Glycogen synthase kinase-3 beta | Homo sapiens | 2206 | Detail |
P42338 |
PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 1951 | Detail |
Q05586 |
GRIN1 | Glutamate receptor ionotropic, NMDA 1 | Homo sapiens | 1847 | Detail |
Q13224 |
GRIN2B | Glutamate receptor ionotropic, NMDA 2B | Homo sapiens | 1823 | Detail |
Q16539 |
MAPK14 | Mitogen-activated protein kinase 14 | Homo sapiens | 1754 | Detail |
P28482 |
MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens | 906 | Detail |
P45983 |
MAPK8 | Mitogen-activated protein kinase 8 | Homo sapiens | 748 | Detail |
Q05655 |
PRKCD | Protein kinase C delta type | Homo sapiens | 742 | Detail |
P45984 |
MAPK9 | Mitogen-activated protein kinase 9 | Homo sapiens | 676 | Detail |
P68400 |
CSNK2A1 | Casein kinase II subunit alpha | Homo sapiens | 639 | Detail |
P53779 |
MAPK10 | Mitogen-activated protein kinase 10 | Homo sapiens | 625 | Detail |
P53778 |
MAPK12 | Mitogen-activated protein kinase 12 | Homo sapiens | 606 | Detail |
Q15759 |
MAPK11 | Mitogen-activated protein kinase 11 | Homo sapiens | 594 | Detail |
O15264 |
MAPK13 | Mitogen-activated protein kinase 13 | Homo sapiens | 533 | Detail |
O00459 |
PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | Homo sapiens | 485 | Detail |
P17612 |
PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | Homo sapiens | 453 | Detail |
P42574 |
CASP3 | Caspase-3 | Homo sapiens | 444 | Detail |
P28074 |
PSMB5 | Proteasome subunit beta type-5 | Homo sapiens | 406 | Detail |
P19784 |
CSNK2A2 | Casein kinase II subunit alpha' | Homo sapiens | 400 | Detail |
P67870 |
CSNK2B | Casein kinase II subunit beta | Homo sapiens | 356 | Detail |
P06241 |
FYN | Tyrosine-protein kinase Fyn | Homo sapiens | 333 | Detail |
Q92569 |
PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | Homo sapiens | 289 | Detail |
Q13509 |
TUBB3 | Tubulin beta-3 chain | Homo sapiens | 278 | Detail |
P68371 |
TUBB4B | Tubulin beta-4B chain | Homo sapiens | 273 | Detail |
P07437 |
TUBB | Tubulin beta chain | Homo sapiens | 273 | Detail |
Q9BVA1 |
TUBB2B | Tubulin beta-2B chain | Homo sapiens | 273 | Detail |
P04350 |
TUBB4A | Tubulin beta-4A chain | Homo sapiens | 272 | Detail |
Q3ZCM7 |
TUBB8 | Tubulin beta-8 chain | Homo sapiens | 271 | Detail |
Q13885 |
TUBB2A | Tubulin beta-2A chain | Homo sapiens | 271 | Detail |
Q9H4B7 |
TUBB1 | Tubulin beta-1 chain | Homo sapiens | 271 | Detail |
Q9BUF5 |
TUBB6 | Tubulin beta-6 chain | Homo sapiens | 271 | Detail |
Q12879 |
GRIN2A | Glutamate receptor ionotropic, NMDA 2A | Homo sapiens | 270 | Detail |
P68366 |
TUBA4A | Tubulin alpha-4A chain | Homo sapiens | 268 | Detail |
Q71U36 |
TUBA1A | Tubulin alpha-1A chain | Homo sapiens | 267 | Detail |
Q9BQE3 |
TUBA1C | Tubulin alpha-1C chain | Homo sapiens | 267 | Detail |
P68363 |
TUBA1B | Tubulin alpha-1B chain | Homo sapiens | 266 | Detail |
Q6PEY2 |
TUBA3E | Tubulin alpha-3E chain | Homo sapiens | 266 | Detail |
P0DPH7 |
TUBA3C | Tubulin alpha-3C chain | Homo sapiens | 266 | Detail |
P49721 |
PSMB2 | Proteasome subunit beta type-2 | Homo sapiens | 263 | Detail |
P20618 |
PSMB1 | Proteasome subunit beta type-1 | Homo sapiens | 249 | Detail |
Q14957 |
GRIN2C | Glutamate receptor ionotropic, NMDA 2C | Homo sapiens | 243 | Detail |
O60391 |
GRIN3B | Glutamate receptor ionotropic, NMDA 3B | Homo sapiens | 240 | Detail |
P27361 |
MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens | 234 | Detail |
O15399 |
GRIN2D | Glutamate receptor ionotropic, NMDA 2D | Homo sapiens | 229 | Detail |
Q8TCU5 |
GRIN3A | Glutamate receptor ionotropic, NMDA 3A | Homo sapiens | 226 | Detail |
P60900 |
PSMA6 | Proteasome subunit alpha type-6 | Homo sapiens | 191 | Detail |
P25786 |
PSMA1 | Proteasome subunit alpha type-1 | Homo sapiens | 187 | Detail |
P25787 |
PSMA2 | Proteasome subunit alpha type-2 | Homo sapiens | 187 | Detail |
P25788 |
PSMA3 | Proteasome subunit alpha type-3 | Homo sapiens | 187 | Detail |
P25789 |
PSMA4 | Proteasome subunit alpha type-4 | Homo sapiens | 187 | Detail |
P49720 |
PSMB3 | Proteasome subunit beta type-3 | Homo sapiens | 187 | Detail |
Q99436 |
PSMB7 | Proteasome subunit beta type-7 | Homo sapiens | 187 | Detail |
Q8TAA3 |
PSMA8 | Proteasome subunit alpha-type 8 | Homo sapiens | 186 | Detail |
P28066 |
PSMA5 | Proteasome subunit alpha type-5 | Homo sapiens | 186 | Detail |
O14818 |
PSMA7 | Proteasome subunit alpha type-7 | Homo sapiens | 186 | Detail |
P28070 |
PSMB4 | Proteasome subunit beta type-4 | Homo sapiens | 186 | Detail |
P28072 |
PSMB6 | Proteasome subunit beta type-6 | Homo sapiens | 186 | Detail |
P30405 |
PPIF | Peptidyl-prolyl cis-trans isomerase F, mitochondrial | Homo sapiens | 172 | Detail |
Q9NZJ5 |
EIF2AK3 | Eukaryotic translation initiation factor 2-alpha kinase 3 | Homo sapiens | 154 | Detail |
P01584 |
IL1B | Interleukin-1 beta | Homo sapiens | 148 | Detail |
Q13936 |
CACNA1C | Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens | 147 | Detail |
P01375 |
TNF | Tumor necrosis factor | Homo sapiens | 144 | Detail |
P22694 |
PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Homo sapiens | 121 | Detail |
Q01668 |
CACNA1D | Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens | 117 | Detail |
O60840 |
CACNA1F | Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens | 117 | Detail |
Q13698 |
CACNA1S | Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens | 117 | Detail |
P22612 |
PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | Homo sapiens | 111 | Detail |
Q8NEV1 |
CSNK2A3 | Casein kinase II subunit alpha 3 | Homo sapiens | 96 | Detail |
Q00975 |
CACNA1B | Voltage-dependent N-type calcium channel subunit alpha-1B | Homo sapiens | 96 | Detail |
P46531 |
NOTCH1 | Neurogenic locus notch homolog protein 1 | Homo sapiens | 84 | Detail |
P33176 |
KIF5B | Kinesin-1 heavy chain | Homo sapiens | 46 | Detail |
O00487 |
PSMD14 | Ubiquitin C-terminal hydrolase PSMD14 | Homo sapiens | 38 | Detail |
P21817 |
RYR1 | Ryanodine receptor 1 | Homo sapiens | 35 | Detail |
P55211 |
CASP9 | Caspase-9 | Homo sapiens | 32 | Detail |
P43686 |
PSMC4 | 26S proteasome regulatory subunit 6B | Homo sapiens | 30 | Detail |
O00231 |
PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | Homo sapiens | 30 | Detail |
Q16186 |
ADRM1 | Proteasomal ubiquitin receptor ADRM1 | Homo sapiens | 29 | Detail |
P62191 |
PSMC1 | 26S proteasome regulatory subunit 4 | Homo sapiens | 29 | Detail |
P17980 |
PSMC3 | 26S proteasome regulatory subunit 6A | Homo sapiens | 29 | Detail |
P62195 |
PSMC5 | 26S proteasome regulatory subunit 8 | Homo sapiens | 29 | Detail |
P62333 |
PSMC6 | 26S proteasome regulatory subunit 10B | Homo sapiens | 29 | Detail |
Q99460 |
PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | Homo sapiens | 29 | Detail |
O43242 |
PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | Homo sapiens | 29 | Detail |
P51665 |
PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | Homo sapiens | 29 | Detail |
P48556 |
PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | Homo sapiens | 29 | Detail |
O00232 |
PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | Homo sapiens | 29 | Detail |
Q15008 |
PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | Homo sapiens | 29 | Detail |
P35998 |
PSMC2 | 26S proteasome regulatory subunit 7 | Homo sapiens | 28 | Detail |
Q13200 |
PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | Homo sapiens | 28 | Detail |
P55036 |
PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | Homo sapiens | 28 | Detail |
Q9UNM6 |
PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | Homo sapiens | 28 | Detail |
P60896 |
SEM1 | 26S proteasome complex subunit SEM1 | Homo sapiens | 28 | Detail |
P48454 |
PPP3CC | Serine/threonine-protein phosphatase 2B catalytic subunit ga | Homo sapiens | 27 | Detail |
Q92934 |
BAD | Bcl2-associated agonist of cell death | Homo sapiens | 27 | Detail |
P05198 |
EIF2S1 | Eukaryotic translation initiation factor 2 subunit 1 | Homo sapiens | 22 | Detail |
P05231 |
IL6 | Interleukin-6 | Homo sapiens | 17 | Detail |
P13501 |
CCL5 | C-C motif chemokine 5 | Homo sapiens | 12 | Detail |
P00403 |
MT-CO2 | Cytochrome c oxidase subunit 2 | Homo sapiens | 8 | Detail |
A6NNZ2 |
TUBB8B | Tubulin beta 8B | Homo sapiens | 7 | Detail |
P04839 |
CYBB | NADPH oxidase 2 | Homo sapiens | 6 | Detail |
P0DMV8 |
HSPA1A | Heat shock 70 kDa protein 1A | Homo sapiens | 6 | Detail |
P11021 |
HSPA5 | Endoplasmic reticulum chaperone BiP | Homo sapiens | 6 | Detail |
P01031 |
C5 | Complement C5 | Homo sapiens | 6 | Detail |
O14727 |
APAF1 | Apoptotic protease-activating factor 1 | Homo sapiens | 5 | Detail |
P11142 |
HSPA8 | Heat shock cognate 71 kDa protein | Homo sapiens | 5 | Detail |
P14598 |
NCF1 | Neutrophil cytosol factor 1 | Homo sapiens | 5 | Detail |
Q14643 |
ITPR1 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 | Homo sapiens | 4 | Detail |
Q14573 |
ITPR3 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 | Homo sapiens | 4 | Detail |
P03905 |
MT-ND4 | NADH-ubiquinone oxidoreductase chain 4 | Homo sapiens | 4 | Detail |
P28331 |
NDUFS1 | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | Homo sapiens | 4 | Detail |
O75306 |
NDUFS2 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitoc | Homo sapiens | 4 | Detail |
Q9P0J0 |
NDUFA13 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | Homo sapiens | 4 | Detail |
Q08209 |
PPP3CA | Protein phosphatase 3 catalytic subunit alpha | Homo sapiens | 4 | Detail |
P12236 |
SLC25A6 | ADP/ATP translocase 3 | Homo sapiens | 3 | Detail |
Q14571 |
ITPR2 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 | Homo sapiens | 3 | Detail |
O75251 |
NDUFS7 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitoc | Homo sapiens | 3 | Detail |
P00395 |
MT-CO1 | Cytochrome c oxidase subunit 1 | Homo sapiens | 3 | Detail |
P00156 |
MT-CYB | Cytochrome b | Homo sapiens | 3 | Detail |
P03886 |
MT-ND1 | NADH-ubiquinone oxidoreductase chain 1 | Homo sapiens | 3 | Detail |
Q16718 |
NDUFA5 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | Homo sapiens | 3 | Detail |
O95299 |
NDUFA10 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | Homo sapiens | 3 | Detail |
O95169 |
NDUFB8 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, | Homo sapiens | 3 | Detail |
Q9Y6M9 |
NDUFB9 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | Homo sapiens | 3 | Detail |
O96000 |
NDUFB10 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | Homo sapiens | 3 | Detail |
O75489 |
NDUFS3 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitoc | Homo sapiens | 3 | Detail |
P19404 |
NDUFV2 | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondria | Homo sapiens | 3 | Detail |
P63000 |
RAC1 | Ras-related C3 botulinum toxin substrate 1 | Homo sapiens | 3 | Detail |
P15153 |
RAC2 | Ras-related C3 botulinum toxin substrate 2 | Homo sapiens | 3 | Detail |
O75947 |
ATP5PD | ATP synthase peripheral stalk subunit d, mitochondrial | Homo sapiens | 2 | Detail |
Q86Y39 |
NDUFA11 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | Homo sapiens | 2 | Detail |
P08574 |
CYC1 | Cytochrome c1, heme protein, mitochondrial | Homo sapiens | 2 | Detail |
P05141 |
SLC25A5 | ADP/ATP translocase 2 | Homo sapiens | 2 | Detail |
P00846 |
MT-ATP6 | ATP synthase F(0) complex subunit a | Homo sapiens | 2 | Detail |
P03891 |
MT-ND2 | NADH-ubiquinone oxidoreductase chain 2 | Homo sapiens | 2 | Detail |
P03897 |
MT-ND3 | NADH-ubiquinone oxidoreductase chain 3 | Homo sapiens | 2 | Detail |
P03901 |
MT-ND4L | NADH-ubiquinone oxidoreductase chain 4L | Homo sapiens | 2 | Detail |
P03915 |
MT-ND5 | NADH-ubiquinone oxidoreductase chain 5 | Homo sapiens | 2 | Detail |
P03923 |
MT-ND6 | NADH-ubiquinone oxidoreductase chain 6 | Homo sapiens | 2 | Detail |
O15239 |
NDUFA1 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | Homo sapiens | 2 | Detail |
O43678 |
NDUFA2 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | Homo sapiens | 2 | Detail |
O95167 |
NDUFA3 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 | Homo sapiens | 2 | Detail |
O00483 |
COXFA4 | Cytochrome c oxidase subunit FA4 | Homo sapiens | 2 | Detail |
P56556 |
NDUFA6 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | Homo sapiens | 2 | Detail |
O95182 |
NDUFA7 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 | Homo sapiens | 2 | Detail |
P51970 |
NDUFA8 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | Homo sapiens | 2 | Detail |
Q16795 |
NDUFA9 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9 | Homo sapiens | 2 | Detail |
O14561 |
NDUFAB1 | Acyl carrier protein, mitochondrial | Homo sapiens | 2 | Detail |
O75438 |
NDUFB1 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 | Homo sapiens | 2 | Detail |
O95178 |
NDUFB2 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, | Homo sapiens | 2 | Detail |
O43676 |
NDUFB3 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | Homo sapiens | 2 | Detail |
O95168 |
NDUFB4 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 | Homo sapiens | 2 | Detail |
O43674 |
NDUFB5 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, | Homo sapiens | 2 | Detail |
O95139 |
NDUFB6 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | Homo sapiens | 2 | Detail |
P17568 |
NDUFB7 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | Homo sapiens | 2 | Detail |
O43677 |
NDUFC1 | NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial | Homo sapiens | 2 | Detail |
O95298 |
NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | Homo sapiens | 2 | Detail |
P49821 |
NDUFV1 | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondria | Homo sapiens | 2 | Detail |
O43181 |
NDUFS4 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitoc | Homo sapiens | 2 | Detail |
O43920 |
NDUFS5 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 | Homo sapiens | 2 | Detail |
O75380 |
NDUFS6 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitoc | Homo sapiens | 2 | Detail |
O00217 |
NDUFS8 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitoc | Homo sapiens | 2 | Detail |
P56181 |
NDUFV3 | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondria | Homo sapiens | 2 | Detail |
Q9NY65 |
TUBA8 | Tubulin alpha-8 chain | Homo sapiens | 2 | Detail |
Q9NX14 |
NDUFB11 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11 | Homo sapiens | 2 | Detail |
Q9UI09 |
NDUFA12 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | Homo sapiens | 2 | Detail |
Q9NRX3 |
COXFA4L2 | Cytochrome c oxidase hypoxia associated subunit FA4L2 | Homo sapiens | 2 | Detail |
P02748 |
C9 | Complement component C9 | Homo sapiens | 2 | Detail |
P22695 |
UQCRC2 | Cytochrome b-c1 complex subunit 2, mitochondrial | Homo sapiens | 2 | Detail |
P21796 |
VDAC1 | Non-selective voltage-gated ion channel VDAC1 | Homo sapiens | 2 | Detail |
Q9Y277 |
VDAC3 | Non-selective voltage-gated ion channel VDAC3 | Homo sapiens | 2 | Detail |
A6NHL2 |
TUBAL3 | Tubulin alpha chain-like 3 | Homo sapiens | 2 | Detail |
P31948 |
STIP1 | Stress-induced-phosphoprotein 1 | Homo sapiens | 1 | Detail |
P13073 |
COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | Homo sapiens | 1 | Detail |
P12074 |
COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | Homo sapiens | 1 | Detail |
P09669 |
COX6C | Cytochrome c oxidase subunit 6C | Homo sapiens | 1 | Detail |
P0DMV9 |
HSPA1B | Heat shock 70 kDa protein 1B | Homo sapiens | 1 | Detail |
P06576 |
ATP5F1B | ATP synthase F(1) complex subunit beta, mitochondrial | Homo sapiens | 1 | Detail |
P24539 |
ATP5PB | ATP synthase peripheral stalk subunit b, mitochondrial | Homo sapiens | 1 | Detail |
P48047 |
ATP5PO | ATP synthase peripheral stalk subunit OSCP, mitochondrial | Homo sapiens | 1 | Detail |
P99999 |
CYCS | Cytochrome c | Homo sapiens | 1 | Detail |
P04156 |
PRNP | Major prion protein | Homo sapiens | 1 | Detail |
O00233 |
PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | Homo sapiens | 1 | Detail |
Q07812 |
BAX | Apoptosis regulator BAX | Homo sapiens | 1 | Detail |
P31040 |
SDHA | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, m | Homo sapiens | 1 | Detail |
P31930 |
UQCRC1 | Cytochrome b-c1 complex subunit 1, mitochondrial | Homo sapiens | 1 | Detail |
P45880 |
VDAC2 | Non-selective voltage-gated ion channel VDAC2 | Homo sapiens | 1 | Detail |
Q8NE86 |
MCU | Calcium uniporter protein, mitochondrial | Homo sapiens | 1 | Detail |