Huntington disease
hsa05016 177 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
Q13547 |
HDAC1 | Histone deacetylase 1 | Homo sapiens | 5940 | Detail |
Q92769 |
HDAC2 | Histone deacetylase 2 | Homo sapiens | 3821 | Detail |
P42345 |
MTOR | Serine/threonine-protein kinase mTOR | Homo sapiens | 2517 | Detail |
Q05586 |
GRIN1 | Glutamate receptor ionotropic, NMDA 1 | Homo sapiens | 1847 | Detail |
Q13224 |
GRIN2B | Glutamate receptor ionotropic, NMDA 2B | Homo sapiens | 1823 | Detail |
P04637 |
TP53 | Cellular tumor antigen p53 | Homo sapiens | 1173 | Detail |
P45983 |
MAPK8 | Mitogen-activated protein kinase 8 | Homo sapiens | 748 | Detail |
P45984 |
MAPK9 | Mitogen-activated protein kinase 9 | Homo sapiens | 676 | Detail |
P53779 |
MAPK10 | Mitogen-activated protein kinase 10 | Homo sapiens | 625 | Detail |
P42574 |
CASP3 | Caspase-3 | Homo sapiens | 444 | Detail |
Q92793 |
CREBBP | CREB-binding protein | Homo sapiens | 423 | Detail |
P37231 |
PPARG | Peroxisome proliferator-activated receptor gamma | Homo sapiens | 417 | Detail |
P28074 |
PSMB5 | Proteasome subunit beta type-5 | Homo sapiens | 406 | Detail |
Q09472 |
EP300 | Histone acetyltransferase p300 | Homo sapiens | 320 | Detail |
Q13509 |
TUBB3 | Tubulin beta-3 chain | Homo sapiens | 278 | Detail |
P68371 |
TUBB4B | Tubulin beta-4B chain | Homo sapiens | 273 | Detail |
P07437 |
TUBB | Tubulin beta chain | Homo sapiens | 273 | Detail |
Q9BVA1 |
TUBB2B | Tubulin beta-2B chain | Homo sapiens | 273 | Detail |
P04350 |
TUBB4A | Tubulin beta-4A chain | Homo sapiens | 272 | Detail |
Q3ZCM7 |
TUBB8 | Tubulin beta-8 chain | Homo sapiens | 271 | Detail |
Q13885 |
TUBB2A | Tubulin beta-2A chain | Homo sapiens | 271 | Detail |
Q9H4B7 |
TUBB1 | Tubulin beta-1 chain | Homo sapiens | 271 | Detail |
Q9BUF5 |
TUBB6 | Tubulin beta-6 chain | Homo sapiens | 271 | Detail |
P68366 |
TUBA4A | Tubulin alpha-4A chain | Homo sapiens | 268 | Detail |
Q71U36 |
TUBA1A | Tubulin alpha-1A chain | Homo sapiens | 267 | Detail |
Q9BQE3 |
TUBA1C | Tubulin alpha-1C chain | Homo sapiens | 267 | Detail |
P68363 |
TUBA1B | Tubulin alpha-1B chain | Homo sapiens | 266 | Detail |
Q6PEY2 |
TUBA3E | Tubulin alpha-3E chain | Homo sapiens | 266 | Detail |
P0DPH7 |
TUBA3C | Tubulin alpha-3C chain | Homo sapiens | 266 | Detail |
P49721 |
PSMB2 | Proteasome subunit beta type-2 | Homo sapiens | 263 | Detail |
P20618 |
PSMB1 | Proteasome subunit beta type-1 | Homo sapiens | 249 | Detail |
Q14790 |
CASP8 | Caspase-8 | Homo sapiens | 219 | Detail |
P60900 |
PSMA6 | Proteasome subunit alpha type-6 | Homo sapiens | 191 | Detail |
P25786 |
PSMA1 | Proteasome subunit alpha type-1 | Homo sapiens | 187 | Detail |
P25787 |
PSMA2 | Proteasome subunit alpha type-2 | Homo sapiens | 187 | Detail |
P25788 |
PSMA3 | Proteasome subunit alpha type-3 | Homo sapiens | 187 | Detail |
P25789 |
PSMA4 | Proteasome subunit alpha type-4 | Homo sapiens | 187 | Detail |
P49720 |
PSMB3 | Proteasome subunit beta type-3 | Homo sapiens | 187 | Detail |
Q99436 |
PSMB7 | Proteasome subunit beta type-7 | Homo sapiens | 187 | Detail |
Q8TAA3 |
PSMA8 | Proteasome subunit alpha-type 8 | Homo sapiens | 186 | Detail |
P28066 |
PSMA5 | Proteasome subunit alpha type-5 | Homo sapiens | 186 | Detail |
O14818 |
PSMA7 | Proteasome subunit alpha type-7 | Homo sapiens | 186 | Detail |
P28070 |
PSMB4 | Proteasome subunit beta type-4 | Homo sapiens | 186 | Detail |
P28072 |
PSMB6 | Proteasome subunit beta type-6 | Homo sapiens | 186 | Detail |
P30405 |
PPIF | Peptidyl-prolyl cis-trans isomerase F, mitochondrial | Homo sapiens | 172 | Detail |
Q9UKL0 |
RCOR1 | REST corepressor 1 | Homo sapiens | 149 | Detail |
P42261 |
GRIA1 | Glutamate receptor 1 | Homo sapiens | 143 | Detail |
P41594 |
GRM5 | Metabotropic glutamate receptor 5 | Homo sapiens | 125 | Detail |
P21980 |
TGM2 | Protein-glutamine gamma-glutamyltransferase 2 | Homo sapiens | 109 | Detail |
P42262 |
GRIA2 | Glutamate receptor 2 | Homo sapiens | 105 | Detail |
P48058 |
GRIA4 | Glutamate receptor 4 | Homo sapiens | 103 | Detail |
Q00975 |
CACNA1B | Voltage-dependent N-type calcium channel subunit alpha-1B | Homo sapiens | 96 | Detail |
P42263 |
GRIA3 | Glutamate receptor 3 | Homo sapiens | 93 | Detail |
Q8NEB9 |
PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3 | Homo sapiens | 93 | Detail |
Q99683 |
MAP3K5 | Mitogen-activated protein kinase kinase kinase 5 | Homo sapiens | 81 | Detail |
O75385 |
ULK1 | Serine/threonine-protein kinase ULK1 | Homo sapiens | 55 | Detail |
O75460 |
ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | Homo sapiens | 46 | Detail |
P33176 |
KIF5B | Kinesin-1 heavy chain | Homo sapiens | 46 | Detail |
Q8IYT8 |
ULK2 | Serine/threonine-protein kinase ULK2 | Homo sapiens | 45 | Detail |
O00487 |
PSMD14 | Ubiquitin C-terminal hydrolase PSMD14 | Homo sapiens | 38 | Detail |
Q02779 |
MAP3K10 | Mitogen-activated protein kinase kinase kinase 10 | Homo sapiens | 33 | Detail |
P43004 |
SLC1A2 | Excitatory amino acid transporter 2 | Homo sapiens | 32 | Detail |
P55211 |
CASP9 | Caspase-9 | Homo sapiens | 32 | Detail |
P43686 |
PSMC4 | 26S proteasome regulatory subunit 6B | Homo sapiens | 30 | Detail |
O00231 |
PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | Homo sapiens | 30 | Detail |
Q16186 |
ADRM1 | Proteasomal ubiquitin receptor ADRM1 | Homo sapiens | 29 | Detail |
P62191 |
PSMC1 | 26S proteasome regulatory subunit 4 | Homo sapiens | 29 | Detail |
P17980 |
PSMC3 | 26S proteasome regulatory subunit 6A | Homo sapiens | 29 | Detail |
P62195 |
PSMC5 | 26S proteasome regulatory subunit 8 | Homo sapiens | 29 | Detail |
P62333 |
PSMC6 | 26S proteasome regulatory subunit 10B | Homo sapiens | 29 | Detail |
Q99460 |
PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | Homo sapiens | 29 | Detail |
O43242 |
PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | Homo sapiens | 29 | Detail |
P51665 |
PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | Homo sapiens | 29 | Detail |
P48556 |
PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | Homo sapiens | 29 | Detail |
O00232 |
PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | Homo sapiens | 29 | Detail |
Q15008 |
PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | Homo sapiens | 29 | Detail |
P35998 |
PSMC2 | 26S proteasome regulatory subunit 7 | Homo sapiens | 28 | Detail |
Q13200 |
PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | Homo sapiens | 28 | Detail |
P55036 |
PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | Homo sapiens | 28 | Detail |
Q9UNM6 |
PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | Homo sapiens | 28 | Detail |
P43003 |
SLC1A3 | Excitatory amino acid transporter 1 | Homo sapiens | 28 | Detail |
P60896 |
SEM1 | 26S proteasome complex subunit SEM1 | Homo sapiens | 28 | Detail |
O14733 |
MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 | Homo sapiens | 15 | Detail |
P00403 |
MT-CO2 | Cytochrome c oxidase subunit 2 | Homo sapiens | 8 | Detail |
A6NNZ2 |
TUBB8B | Tubulin beta 8B | Homo sapiens | 7 | Detail |
Q14457 |
BECN1 | Beclin-1 | Homo sapiens | 7 | Detail |
O14727 |
APAF1 | Apoptotic protease-activating factor 1 | Homo sapiens | 5 | Detail |
Q14643 |
ITPR1 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 | Homo sapiens | 4 | Detail |
P03905 |
MT-ND4 | NADH-ubiquinone oxidoreductase chain 4 | Homo sapiens | 4 | Detail |
P28331 |
NDUFS1 | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | Homo sapiens | 4 | Detail |
O75306 |
NDUFS2 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitoc | Homo sapiens | 4 | Detail |
Q9P0J0 |
NDUFA13 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | Homo sapiens | 4 | Detail |
P12236 |
SLC25A6 | ADP/ATP translocase 3 | Homo sapiens | 3 | Detail |
O75251 |
NDUFS7 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitoc | Homo sapiens | 3 | Detail |
P00395 |
MT-CO1 | Cytochrome c oxidase subunit 1 | Homo sapiens | 3 | Detail |
P00156 |
MT-CYB | Cytochrome b | Homo sapiens | 3 | Detail |
P03886 |
MT-ND1 | NADH-ubiquinone oxidoreductase chain 1 | Homo sapiens | 3 | Detail |
Q16718 |
NDUFA5 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | Homo sapiens | 3 | Detail |
O95299 |
NDUFA10 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | Homo sapiens | 3 | Detail |
O95169 |
NDUFB8 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, | Homo sapiens | 3 | Detail |
Q9Y6M9 |
NDUFB9 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | Homo sapiens | 3 | Detail |
O96000 |
NDUFB10 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | Homo sapiens | 3 | Detail |
O75489 |
NDUFS3 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitoc | Homo sapiens | 3 | Detail |
P19404 |
NDUFV2 | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondria | Homo sapiens | 3 | Detail |
O75947 |
ATP5PD | ATP synthase peripheral stalk subunit d, mitochondrial | Homo sapiens | 2 | Detail |
P53680 |
AP2S1 | AP-2 complex subunit sigma | Homo sapiens | 2 | Detail |
P09496 |
CLTA | Clathrin light chain A | Homo sapiens | 2 | Detail |
Q00610 |
CLTC | Clathrin heavy chain 1 | Homo sapiens | 2 | Detail |
Q86Y39 |
NDUFA11 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | Homo sapiens | 2 | Detail |
P08574 |
CYC1 | Cytochrome c1, heme protein, mitochondrial | Homo sapiens | 2 | Detail |
P50148 |
GNAQ | Guanine nucleotide-binding protein G(q) subunit alpha | Homo sapiens | 2 | Detail |
P05141 |
SLC25A5 | ADP/ATP translocase 2 | Homo sapiens | 2 | Detail |
P42858 |
HTT | Huntingtin | Homo sapiens | 2 | Detail |
P00846 |
MT-ATP6 | ATP synthase F(0) complex subunit a | Homo sapiens | 2 | Detail |
P03891 |
MT-ND2 | NADH-ubiquinone oxidoreductase chain 2 | Homo sapiens | 2 | Detail |
P03897 |
MT-ND3 | NADH-ubiquinone oxidoreductase chain 3 | Homo sapiens | 2 | Detail |
P03901 |
MT-ND4L | NADH-ubiquinone oxidoreductase chain 4L | Homo sapiens | 2 | Detail |
P03915 |
MT-ND5 | NADH-ubiquinone oxidoreductase chain 5 | Homo sapiens | 2 | Detail |
P03923 |
MT-ND6 | NADH-ubiquinone oxidoreductase chain 6 | Homo sapiens | 2 | Detail |
O15239 |
NDUFA1 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | Homo sapiens | 2 | Detail |
O43678 |
NDUFA2 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | Homo sapiens | 2 | Detail |
O95167 |
NDUFA3 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 | Homo sapiens | 2 | Detail |
O00483 |
COXFA4 | Cytochrome c oxidase subunit FA4 | Homo sapiens | 2 | Detail |
P56556 |
NDUFA6 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | Homo sapiens | 2 | Detail |
O95182 |
NDUFA7 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 | Homo sapiens | 2 | Detail |
P51970 |
NDUFA8 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | Homo sapiens | 2 | Detail |
Q16795 |
NDUFA9 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9 | Homo sapiens | 2 | Detail |
O14561 |
NDUFAB1 | Acyl carrier protein, mitochondrial | Homo sapiens | 2 | Detail |
O75438 |
NDUFB1 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 | Homo sapiens | 2 | Detail |
O95178 |
NDUFB2 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, | Homo sapiens | 2 | Detail |
O43676 |
NDUFB3 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | Homo sapiens | 2 | Detail |
O95168 |
NDUFB4 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 | Homo sapiens | 2 | Detail |
O43674 |
NDUFB5 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, | Homo sapiens | 2 | Detail |
O95139 |
NDUFB6 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | Homo sapiens | 2 | Detail |
P17568 |
NDUFB7 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | Homo sapiens | 2 | Detail |
O43677 |
NDUFC1 | NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial | Homo sapiens | 2 | Detail |
O95298 |
NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | Homo sapiens | 2 | Detail |
P49821 |
NDUFV1 | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondria | Homo sapiens | 2 | Detail |
O43181 |
NDUFS4 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitoc | Homo sapiens | 2 | Detail |
O43920 |
NDUFS5 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 | Homo sapiens | 2 | Detail |
O75380 |
NDUFS6 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitoc | Homo sapiens | 2 | Detail |
O00217 |
NDUFS8 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitoc | Homo sapiens | 2 | Detail |
P56181 |
NDUFV3 | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondria | Homo sapiens | 2 | Detail |
Q9NY65 |
TUBA8 | Tubulin alpha-8 chain | Homo sapiens | 2 | Detail |
P30876 |
POLR2B | DNA-directed RNA polymerase II subunit RPB2 | Homo sapiens | 2 | Detail |
Q9NX14 |
NDUFB11 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11 | Homo sapiens | 2 | Detail |
Q9UI09 |
NDUFA12 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | Homo sapiens | 2 | Detail |
Q9NRX3 |
COXFA4L2 | Cytochrome c oxidase hypoxia associated subunit FA4L2 | Homo sapiens | 2 | Detail |
P22695 |
UQCRC2 | Cytochrome b-c1 complex subunit 2, mitochondrial | Homo sapiens | 2 | Detail |
P21796 |
VDAC1 | Non-selective voltage-gated ion channel VDAC1 | Homo sapiens | 2 | Detail |
Q9Y277 |
VDAC3 | Non-selective voltage-gated ion channel VDAC3 | Homo sapiens | 2 | Detail |
A6NHL2 |
TUBAL3 | Tubulin alpha chain-like 3 | Homo sapiens | 2 | Detail |
P13073 |
COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | Homo sapiens | 1 | Detail |
P12074 |
COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | Homo sapiens | 1 | Detail |
P09669 |
COX6C | Cytochrome c oxidase subunit 6C | Homo sapiens | 1 | Detail |
O95782 |
AP2A1 | AP-2 complex subunit alpha-1 | Homo sapiens | 1 | Detail |
P63010 |
AP2B1 | AP-2 complex subunit beta | Homo sapiens | 1 | Detail |
Q14203 |
DCTN1 | Dynactin subunit 1 | Homo sapiens | 1 | Detail |
Q6ZR08 |
DNAH12 | Dynein axonemal heavy chain 12 | Homo sapiens | 1 | Detail |
Q96ST3 |
SIN3A | Paired amphipathic helix protein Sin3a | Homo sapiens | 1 | Detail |
Q9BXH1 |
BBC3 | Bcl-2-binding component 3, isoforms 1/2 | Homo sapiens | 1 | Detail |
Q99570 |
PIK3R4 | Phosphoinositide 3-kinase regulatory subunit 4 | Homo sapiens | 1 | Detail |
P06576 |
ATP5F1B | ATP synthase F(1) complex subunit beta, mitochondrial | Homo sapiens | 1 | Detail |
P24539 |
ATP5PB | ATP synthase peripheral stalk subunit b, mitochondrial | Homo sapiens | 1 | Detail |
P48047 |
ATP5PO | ATP synthase peripheral stalk subunit OSCP, mitochondrial | Homo sapiens | 1 | Detail |
P99999 |
CYCS | Cytochrome c | Homo sapiens | 1 | Detail |
P24928 |
POLR2A | DNA-directed RNA polymerase II subunit RPB1 | Homo sapiens | 1 | Detail |
P19388 |
POLR2E | DNA-directed RNA polymerases I, II, and III subunit RPABC1 | Homo sapiens | 1 | Detail |
P52434 |
POLR2H | DNA-directed RNA polymerases I, II, and III subunit RPABC3 | Homo sapiens | 1 | Detail |
O00233 |
PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | Homo sapiens | 1 | Detail |
Q07812 |
BAX | Apoptosis regulator BAX | Homo sapiens | 1 | Detail |
P31040 |
SDHA | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, m | Homo sapiens | 1 | Detail |
Q00059 |
TFAM | Transcription factor A, mitochondrial | Homo sapiens | 1 | Detail |
Q12933 |
TRAF2 | TNF receptor-associated factor 2 | Homo sapiens | 1 | Detail |
P31930 |
UQCRC1 | Cytochrome b-c1 complex subunit 1, mitochondrial | Homo sapiens | 1 | Detail |
P45880 |
VDAC2 | Non-selective voltage-gated ion channel VDAC2 | Homo sapiens | 1 | Detail |
O75143 |
ATG13 | Autophagy-related protein 13 | Homo sapiens | 1 | Detail |