Amyotrophic lateral sclerosis

hsa05014 202 targets in this pathway

UniProt AC Gene Protein Name Organism Multi-Target Molecules
Q9UBN7 HDAC6 Protein deacetylase HDAC6 Homo sapiens 4526 Detail
P42345 MTOR Serine/threonine-protein kinase mTOR Homo sapiens 2517 Detail
Q05586 GRIN1 Glutamate receptor ionotropic, NMDA 1 Homo sapiens 1847 Detail
Q13224 GRIN2B Glutamate receptor ionotropic, NMDA 2B Homo sapiens 1823 Detail
Q16539 MAPK14 Mitogen-activated protein kinase 14 Homo sapiens 1754 Detail
P04637 TP53 Cellular tumor antigen p53 Homo sapiens 1173 Detail
P10415 BCL2 Apoptosis regulator Bcl-2 Homo sapiens 1065 Detail
Q07817 BCL2L1 Bcl-2-like protein 1 Homo sapiens 990 Detail
Q99720 SIGMAR1 Sigma non-opioid intracellular receptor 1 Homo sapiens 923 Detail
Q9UHD2 TBK1 Serine/threonine-protein kinase TBK1 Homo sapiens 639 Detail
P53778 MAPK12 Mitogen-activated protein kinase 12 Homo sapiens 606 Detail
Q15759 MAPK11 Mitogen-activated protein kinase 11 Homo sapiens 594 Detail
O15264 MAPK13 Mitogen-activated protein kinase 13 Homo sapiens 533 Detail
P42574 CASP3 Caspase-3 Homo sapiens 444 Detail
P28074 PSMB5 Proteasome subunit beta type-5 Homo sapiens 406 Detail
Q15303 ERBB4 Receptor tyrosine-protein kinase erbB-4 Homo sapiens 336 Detail
Q13509 TUBB3 Tubulin beta-3 chain Homo sapiens 278 Detail
P68371 TUBB4B Tubulin beta-4B chain Homo sapiens 273 Detail
P07437 TUBB Tubulin beta chain Homo sapiens 273 Detail
Q9BVA1 TUBB2B Tubulin beta-2B chain Homo sapiens 273 Detail
P04350 TUBB4A Tubulin beta-4A chain Homo sapiens 272 Detail
Q3ZCM7 TUBB8 Tubulin beta-8 chain Homo sapiens 271 Detail
Q13885 TUBB2A Tubulin beta-2A chain Homo sapiens 271 Detail
Q9H4B7 TUBB1 Tubulin beta-1 chain Homo sapiens 271 Detail
Q9BUF5 TUBB6 Tubulin beta-6 chain Homo sapiens 271 Detail
Q12879 GRIN2A Glutamate receptor ionotropic, NMDA 2A Homo sapiens 270 Detail
P68366 TUBA4A Tubulin alpha-4A chain Homo sapiens 268 Detail
Q71U36 TUBA1A Tubulin alpha-1A chain Homo sapiens 267 Detail
Q9BQE3 TUBA1C Tubulin alpha-1C chain Homo sapiens 267 Detail
P68363 TUBA1B Tubulin alpha-1B chain Homo sapiens 266 Detail
Q6PEY2 TUBA3E Tubulin alpha-3E chain Homo sapiens 266 Detail
P0DPH7 TUBA3C Tubulin alpha-3C chain Homo sapiens 266 Detail
P49721 PSMB2 Proteasome subunit beta type-2 Homo sapiens 263 Detail
P20618 PSMB1 Proteasome subunit beta type-1 Homo sapiens 249 Detail
Q14957 GRIN2C Glutamate receptor ionotropic, NMDA 2C Homo sapiens 243 Detail
O15399 GRIN2D Glutamate receptor ionotropic, NMDA 2D Homo sapiens 229 Detail
P60900 PSMA6 Proteasome subunit alpha type-6 Homo sapiens 191 Detail
P25786 PSMA1 Proteasome subunit alpha type-1 Homo sapiens 187 Detail
P25787 PSMA2 Proteasome subunit alpha type-2 Homo sapiens 187 Detail
P25788 PSMA3 Proteasome subunit alpha type-3 Homo sapiens 187 Detail
P25789 PSMA4 Proteasome subunit alpha type-4 Homo sapiens 187 Detail
P49720 PSMB3 Proteasome subunit beta type-3 Homo sapiens 187 Detail
Q99436 PSMB7 Proteasome subunit beta type-7 Homo sapiens 187 Detail
Q8TAA3 PSMA8 Proteasome subunit alpha-type 8 Homo sapiens 186 Detail
P28066 PSMA5 Proteasome subunit alpha type-5 Homo sapiens 186 Detail
O14818 PSMA7 Proteasome subunit alpha type-7 Homo sapiens 186 Detail
P28070 PSMB4 Proteasome subunit beta type-4 Homo sapiens 186 Detail
P28072 PSMB6 Proteasome subunit beta type-6 Homo sapiens 186 Detail
P29466 CASP1 Caspase-1 Homo sapiens 173 Detail
P29475 NOS1 Nitric oxide synthase 1 Homo sapiens 161 Detail
Q9NZJ5 EIF2AK3 Eukaryotic translation initiation factor 2-alpha kinase 3 Homo sapiens 154 Detail
P35228 NOS2 Nitric oxide synthase, inducible Homo sapiens 150 Detail
Q99700 ATXN2 Ataxin-2 Homo sapiens 147 Detail
P01375 TNF Tumor necrosis factor Homo sapiens 144 Detail
P42261 GRIA1 Glutamate receptor 1 Homo sapiens 143 Detail
P42262 GRIA2 Glutamate receptor 2 Homo sapiens 105 Detail
Q8NEB9 PIK3C3 Phosphatidylinositol 3-kinase catalytic subunit type 3 Homo sapiens 93 Detail
Q99683 MAP3K5 Mitogen-activated protein kinase kinase kinase 5 Homo sapiens 81 Detail
O75385 ULK1 Serine/threonine-protein kinase ULK1 Homo sapiens 55 Detail
O75460 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens 46 Detail
P33176 KIF5B Kinesin-1 heavy chain Homo sapiens 46 Detail
Q8IYT8 ULK2 Serine/threonine-protein kinase ULK2 Homo sapiens 45 Detail
P55957 BID BH3-interacting domain death agonist Homo sapiens 41 Detail
O00487 PSMD14 Ubiquitin C-terminal hydrolase PSMD14 Homo sapiens 38 Detail
P43004 SLC1A2 Excitatory amino acid transporter 2 Homo sapiens 32 Detail
P55211 CASP9 Caspase-9 Homo sapiens 32 Detail
P43686 PSMC4 26S proteasome regulatory subunit 6B Homo sapiens 30 Detail
O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 Homo sapiens 30 Detail
Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 Homo sapiens 29 Detail
P62191 PSMC1 26S proteasome regulatory subunit 4 Homo sapiens 29 Detail
P17980 PSMC3 26S proteasome regulatory subunit 6A Homo sapiens 29 Detail
P62195 PSMC5 26S proteasome regulatory subunit 8 Homo sapiens 29 Detail
P62333 PSMC6 26S proteasome regulatory subunit 10B Homo sapiens 29 Detail
Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 Homo sapiens 29 Detail
O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 Homo sapiens 29 Detail
P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 Homo sapiens 29 Detail
P48556 PSMD8 26S proteasome non-ATPase regulatory subunit 8 Homo sapiens 29 Detail
O00232 PSMD12 26S proteasome non-ATPase regulatory subunit 12 Homo sapiens 29 Detail
Q15008 PSMD6 26S proteasome non-ATPase regulatory subunit 6 Homo sapiens 29 Detail
P35998 PSMC2 26S proteasome regulatory subunit 7 Homo sapiens 28 Detail
Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 Homo sapiens 28 Detail
P55036 PSMD4 26S proteasome non-ATPase regulatory subunit 4 Homo sapiens 28 Detail
Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 Homo sapiens 28 Detail
P60896 SEM1 26S proteasome complex subunit SEM1 Homo sapiens 28 Detail
P48454 PPP3CC Serine/threonine-protein phosphatase 2B catalytic subunit ga Homo sapiens 27 Detail
Q92934 BAD Bcl2-associated agonist of cell death Homo sapiens 27 Detail
P05198 EIF2S1 Eukaryotic translation initiation factor 2 subunit 1 Homo sapiens 22 Detail
P52564 MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens 17 Detail
P17861 XBP1 X-box-binding protein 1 Homo sapiens 14 Detail
P46734 MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 Homo sapiens 12 Detail
P00403 MT-CO2 Cytochrome c oxidase subunit 2 Homo sapiens 8 Detail
A6NNZ2 TUBB8B Tubulin beta 8B Homo sapiens 7 Detail
Q14457 BECN1 Beclin-1 Homo sapiens 7 Detail
P11021 HSPA5 Endoplasmic reticulum chaperone BiP Homo sapiens 6 Detail
P55072 VCP Transitional endoplasmic reticulum ATPase Homo sapiens 6 Detail
Q9GZQ8 MAP1LC3B Microtubule-associated protein 1 light chain 3 beta Homo sapiens 6 Detail
O14727 APAF1 Apoptotic protease-activating factor 1 Homo sapiens 5 Detail
Q14573 ITPR3 Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 Homo sapiens 4 Detail
P03905 MT-ND4 NADH-ubiquinone oxidoreductase chain 4 Homo sapiens 4 Detail
P28331 NDUFS1 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial Homo sapiens 4 Detail
O75306 NDUFS2 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitoc Homo sapiens 4 Detail
Q9P0J0 NDUFA13 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Homo sapiens 4 Detail
Q08209 PPP3CA Protein phosphatase 3 catalytic subunit alpha Homo sapiens 4 Detail
O75251 NDUFS7 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitoc Homo sapiens 3 Detail
P00395 MT-CO1 Cytochrome c oxidase subunit 1 Homo sapiens 3 Detail
P00156 MT-CYB Cytochrome b Homo sapiens 3 Detail
P03886 MT-ND1 NADH-ubiquinone oxidoreductase chain 1 Homo sapiens 3 Detail
Q16718 NDUFA5 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 Homo sapiens 3 Detail
O95299 NDUFA10 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Homo sapiens 3 Detail
O95169 NDUFB8 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, Homo sapiens 3 Detail
Q9Y6M9 NDUFB9 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 Homo sapiens 3 Detail
O96000 NDUFB10 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 Homo sapiens 3 Detail
O75489 NDUFS3 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitoc Homo sapiens 3 Detail
P19404 NDUFV2 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondria Homo sapiens 3 Detail
P63000 RAC1 Ras-related C3 botulinum toxin substrate 1 Homo sapiens 3 Detail
Q16629 SRSF7 Serine/arginine-rich splicing factor 7 Homo sapiens 3 Detail
Q9BXM7 PINK1 Serine/threonine-protein kinase PINK1, mitochondrial Homo sapiens 3 Detail
O75947 ATP5PD ATP synthase peripheral stalk subunit d, mitochondrial Homo sapiens 2 Detail
Q86Y39 NDUFA11 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Homo sapiens 2 Detail
P08574 CYC1 Cytochrome c1, heme protein, mitochondrial Homo sapiens 2 Detail
Q13148 TARDBP TAR DNA-binding protein 43 Homo sapiens 2 Detail
P35637 FUS RNA-binding protein FUS Homo sapiens 2 Detail
P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 Homo sapiens 2 Detail
P00846 MT-ATP6 ATP synthase F(0) complex subunit a Homo sapiens 2 Detail
P03891 MT-ND2 NADH-ubiquinone oxidoreductase chain 2 Homo sapiens 2 Detail
P03897 MT-ND3 NADH-ubiquinone oxidoreductase chain 3 Homo sapiens 2 Detail
P03901 MT-ND4L NADH-ubiquinone oxidoreductase chain 4L Homo sapiens 2 Detail
P03915 MT-ND5 NADH-ubiquinone oxidoreductase chain 5 Homo sapiens 2 Detail
P03923 MT-ND6 NADH-ubiquinone oxidoreductase chain 6 Homo sapiens 2 Detail
Q09161 NCBP1 Nuclear cap-binding protein subunit 1 Homo sapiens 2 Detail
O15239 NDUFA1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Homo sapiens 2 Detail
O43678 NDUFA2 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 Homo sapiens 2 Detail
O95167 NDUFA3 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 Homo sapiens 2 Detail
O00483 COXFA4 Cytochrome c oxidase subunit FA4 Homo sapiens 2 Detail
P56556 NDUFA6 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 Homo sapiens 2 Detail
O95182 NDUFA7 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 Homo sapiens 2 Detail
P51970 NDUFA8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 Homo sapiens 2 Detail
Q16795 NDUFA9 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9 Homo sapiens 2 Detail
O14561 NDUFAB1 Acyl carrier protein, mitochondrial Homo sapiens 2 Detail
O75438 NDUFB1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 Homo sapiens 2 Detail
O95178 NDUFB2 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, Homo sapiens 2 Detail
O43676 NDUFB3 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 Homo sapiens 2 Detail
O95168 NDUFB4 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 Homo sapiens 2 Detail
O43674 NDUFB5 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, Homo sapiens 2 Detail
O95139 NDUFB6 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 Homo sapiens 2 Detail
P17568 NDUFB7 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 Homo sapiens 2 Detail
O43677 NDUFC1 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial Homo sapiens 2 Detail
O95298 NDUFC2 NADH dehydrogenase [ubiquinone] 1 subunit C2 Homo sapiens 2 Detail
P49821 NDUFV1 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondria Homo sapiens 2 Detail
O43181 NDUFS4 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitoc Homo sapiens 2 Detail
O43920 NDUFS5 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 Homo sapiens 2 Detail
O75380 NDUFS6 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitoc Homo sapiens 2 Detail
O00217 NDUFS8 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitoc Homo sapiens 2 Detail
P56181 NDUFV3 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondria Homo sapiens 2 Detail
Q9NY65 TUBA8 Tubulin alpha-8 chain Homo sapiens 2 Detail
Q9NX14 NDUFB11 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11 Homo sapiens 2 Detail
Q9UI09 NDUFA12 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Homo sapiens 2 Detail
P41219 PRPH Peripherin Homo sapiens 2 Detail
Q9NRX3 COXFA4L2 Cytochrome c oxidase hypoxia associated subunit FA4L2 Homo sapiens 2 Detail
P19438 TNFRSF1A Tumor necrosis factor receptor superfamily member 1A Homo sapiens 2 Detail
P22695 UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial Homo sapiens 2 Detail
P21796 VDAC1 Non-selective voltage-gated ion channel VDAC1 Homo sapiens 2 Detail
A6NHL2 TUBAL3 Tubulin alpha chain-like 3 Homo sapiens 2 Detail
O75694 NUP155 Nuclear pore complex protein Nup155 Homo sapiens 2 Detail
P43243 MATR3 Matrin-3 Homo sapiens 2 Detail
Q92844 TANK TRAF family member-associated NF-kappa-B activator Homo sapiens 1 Detail
Q9UBU9 NXF1 Nuclear RNA export factor 1 Homo sapiens 1 Detail
Q9UKX7 NUP50 Nuclear pore complex protein Nup50 Homo sapiens 1 Detail
P13073 COX4I1 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Homo sapiens 1 Detail
P12074 COX6A1 Cytochrome c oxidase subunit 6A1, mitochondrial Homo sapiens 1 Detail
P09669 COX6C Cytochrome c oxidase subunit 6C Homo sapiens 1 Detail
Q14203 DCTN1 Dynactin subunit 1 Homo sapiens 1 Detail
Q6ZR08 DNAH12 Dynein axonemal heavy chain 12 Homo sapiens 1 Detail
P51991 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 Homo sapiens 1 Detail
Q12769 NUP160 Nuclear pore complex protein Nup160 Homo sapiens 1 Detail
Q5SRE5 NUP188 Nucleoporin NUP188 Homo sapiens 1 Detail
Q9UMX0 UBQLN1 Ubiquilin-1 Homo sapiens 1 Detail
Q99570 PIK3R4 Phosphoinositide 3-kinase regulatory subunit 4 Homo sapiens 1 Detail
P20073 ANXA7 Annexin A7 Homo sapiens 1 Detail
P09651 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1 Homo sapiens 1 Detail
P07197 NEFM Neurofilament medium polypeptide Homo sapiens 1 Detail
P06576 ATP5F1B ATP synthase F(1) complex subunit beta, mitochondrial Homo sapiens 1 Detail
P24539 ATP5PB ATP synthase peripheral stalk subunit b, mitochondrial Homo sapiens 1 Detail
P48047 ATP5PO ATP synthase peripheral stalk subunit OSCP, mitochondrial Homo sapiens 1 Detail
P99999 CYCS Cytochrome c Homo sapiens 1 Detail
O00233 PSMD9 26S proteasome non-ATPase regulatory subunit 9 Homo sapiens 1 Detail
Q07812 BAX Apoptosis regulator BAX Homo sapiens 1 Detail
P31040 SDHA Succinate dehydrogenase [ubiquinone] flavoprotein subunit, m Homo sapiens 1 Detail
P55735 SEC13 Protein SEC13 homolog Homo sapiens 1 Detail
P84103 SRSF3 Serine/arginine-rich splicing factor 3 Homo sapiens 1 Detail
P20333 TNFRSF1B Tumor necrosis factor receptor superfamily member 1B Homo sapiens 1 Detail
Q12933 TRAF2 TNF receptor-associated factor 2 Homo sapiens 1 Detail
P31930 UQCRC1 Cytochrome b-c1 complex subunit 1, mitochondrial Homo sapiens 1 Detail
Q96JI7 SPG11 Spatacsin Homo sapiens 1 Detail
Q9H492 MAP1LC3A Microtubule-associated protein 1 light chain 3 alpha Homo sapiens 1 Detail
P04040 CAT Catalase Homo sapiens 1 Detail
P78406 RAE1 mRNA export factor RAE1 Homo sapiens 1 Detail
Q13501 SQSTM1 Sequestosome-1 Homo sapiens 1 Detail
Q8NE86 MCU Calcium uniporter protein, mitochondrial Homo sapiens 1 Detail
O95292 VAPB Vesicle-associated membrane protein-associated protein B/C Homo sapiens 1 Detail
Q8N1F7 NUP93 Nuclear pore complex protein Nup93 Homo sapiens 1 Detail
O75143 ATG13 Autophagy-related protein 13 Homo sapiens 1 Detail