Parkinson disease
hsa05012 180 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
P14416 |
DRD2 | D(2) dopamine receptor | Homo sapiens | 6392 | Detail |
P29274 |
ADORA2A | Adenosine receptor A2a | Homo sapiens | 4217 | Detail |
Q01959 |
SLC6A3 | Sodium-dependent dopamine transporter | Homo sapiens | 1959 | Detail |
P04637 |
TP53 | Cellular tumor antigen p53 | Homo sapiens | 1173 | Detail |
Q07817 |
BCL2L1 | Bcl-2-like protein 1 | Homo sapiens | 990 | Detail |
P45983 |
MAPK8 | Mitogen-activated protein kinase 8 | Homo sapiens | 748 | Detail |
P21728 |
DRD1 | D(1A) dopamine receptor | Homo sapiens | 738 | Detail |
P45984 |
MAPK9 | Mitogen-activated protein kinase 9 | Homo sapiens | 676 | Detail |
P27338 |
MAOB | Amine oxidase [flavin-containing] B | Homo sapiens | 657 | Detail |
P53779 |
MAPK10 | Mitogen-activated protein kinase 10 | Homo sapiens | 625 | Detail |
Q14145 |
KEAP1 | Kelch-like ECH-associated protein 1 | Homo sapiens | 558 | Detail |
Q16236 |
NFE2L2 | Nuclear factor erythroid 2-related factor 2 | Homo sapiens | 557 | Detail |
P21397 |
MAOA | Amine oxidase [flavin-containing] A | Homo sapiens | 522 | Detail |
P17612 |
PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | Homo sapiens | 453 | Detail |
P42574 |
CASP3 | Caspase-3 | Homo sapiens | 444 | Detail |
P28074 |
PSMB5 | Proteasome subunit beta type-5 | Homo sapiens | 406 | Detail |
Q5S007 |
LRRK2 | Leucine-rich repeat serine/threonine-protein kinase 2 | Homo sapiens | 299 | Detail |
Q13509 |
TUBB3 | Tubulin beta-3 chain | Homo sapiens | 278 | Detail |
P68371 |
TUBB4B | Tubulin beta-4B chain | Homo sapiens | 273 | Detail |
P07437 |
TUBB | Tubulin beta chain | Homo sapiens | 273 | Detail |
Q9BVA1 |
TUBB2B | Tubulin beta-2B chain | Homo sapiens | 273 | Detail |
P04350 |
TUBB4A | Tubulin beta-4A chain | Homo sapiens | 272 | Detail |
Q3ZCM7 |
TUBB8 | Tubulin beta-8 chain | Homo sapiens | 271 | Detail |
Q13885 |
TUBB2A | Tubulin beta-2A chain | Homo sapiens | 271 | Detail |
Q9H4B7 |
TUBB1 | Tubulin beta-1 chain | Homo sapiens | 271 | Detail |
Q9BUF5 |
TUBB6 | Tubulin beta-6 chain | Homo sapiens | 271 | Detail |
P68366 |
TUBA4A | Tubulin alpha-4A chain | Homo sapiens | 268 | Detail |
Q71U36 |
TUBA1A | Tubulin alpha-1A chain | Homo sapiens | 267 | Detail |
Q9BQE3 |
TUBA1C | Tubulin alpha-1C chain | Homo sapiens | 267 | Detail |
P68363 |
TUBA1B | Tubulin alpha-1B chain | Homo sapiens | 266 | Detail |
Q6PEY2 |
TUBA3E | Tubulin alpha-3E chain | Homo sapiens | 266 | Detail |
P0DPH7 |
TUBA3C | Tubulin alpha-3C chain | Homo sapiens | 266 | Detail |
P49721 |
PSMB2 | Proteasome subunit beta type-2 | Homo sapiens | 263 | Detail |
P20618 |
PSMB1 | Proteasome subunit beta type-1 | Homo sapiens | 249 | Detail |
P60900 |
PSMA6 | Proteasome subunit alpha type-6 | Homo sapiens | 191 | Detail |
P25786 |
PSMA1 | Proteasome subunit alpha type-1 | Homo sapiens | 187 | Detail |
P25787 |
PSMA2 | Proteasome subunit alpha type-2 | Homo sapiens | 187 | Detail |
P25788 |
PSMA3 | Proteasome subunit alpha type-3 | Homo sapiens | 187 | Detail |
P25789 |
PSMA4 | Proteasome subunit alpha type-4 | Homo sapiens | 187 | Detail |
P49720 |
PSMB3 | Proteasome subunit beta type-3 | Homo sapiens | 187 | Detail |
Q99436 |
PSMB7 | Proteasome subunit beta type-7 | Homo sapiens | 187 | Detail |
Q8TAA3 |
PSMA8 | Proteasome subunit alpha-type 8 | Homo sapiens | 186 | Detail |
P28066 |
PSMA5 | Proteasome subunit alpha type-5 | Homo sapiens | 186 | Detail |
O14818 |
PSMA7 | Proteasome subunit alpha type-7 | Homo sapiens | 186 | Detail |
P28070 |
PSMB4 | Proteasome subunit beta type-4 | Homo sapiens | 186 | Detail |
P28072 |
PSMB6 | Proteasome subunit beta type-6 | Homo sapiens | 186 | Detail |
P30405 |
PPIF | Peptidyl-prolyl cis-trans isomerase F, mitochondrial | Homo sapiens | 172 | Detail |
Q9NZJ5 |
EIF2AK3 | Eukaryotic translation initiation factor 2-alpha kinase 3 | Homo sapiens | 154 | Detail |
P10636 |
MAPT | Microtubule-associated protein tau | Homo sapiens | 150 | Detail |
Q13557 |
CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 150 | Detail |
Q13555 |
CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 123 | Detail |
P22694 |
PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Homo sapiens | 121 | Detail |
P22612 |
PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | Homo sapiens | 111 | Detail |
Q99683 |
MAP3K5 | Mitogen-activated protein kinase kinase kinase 5 | Homo sapiens | 81 | Detail |
Q9UQM7 |
CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 75 | Detail |
Q13554 |
CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 68 | Detail |
P37840 |
SNCA | Alpha-synuclein | Homo sapiens | 64 | Detail |
O75460 |
ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | Homo sapiens | 46 | Detail |
P33176 |
KIF5B | Kinesin-1 heavy chain | Homo sapiens | 46 | Detail |
O00487 |
PSMD14 | Ubiquitin C-terminal hydrolase PSMD14 | Homo sapiens | 38 | Detail |
P55211 |
CASP9 | Caspase-9 | Homo sapiens | 32 | Detail |
P43686 |
PSMC4 | 26S proteasome regulatory subunit 6B | Homo sapiens | 30 | Detail |
O00231 |
PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | Homo sapiens | 30 | Detail |
P22314 |
UBA1 | Ubiquitin-like modifier-activating enzyme 1 | Homo sapiens | 30 | Detail |
Q16186 |
ADRM1 | Proteasomal ubiquitin receptor ADRM1 | Homo sapiens | 29 | Detail |
P62191 |
PSMC1 | 26S proteasome regulatory subunit 4 | Homo sapiens | 29 | Detail |
P17980 |
PSMC3 | 26S proteasome regulatory subunit 6A | Homo sapiens | 29 | Detail |
P62195 |
PSMC5 | 26S proteasome regulatory subunit 8 | Homo sapiens | 29 | Detail |
P62333 |
PSMC6 | 26S proteasome regulatory subunit 10B | Homo sapiens | 29 | Detail |
Q99460 |
PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | Homo sapiens | 29 | Detail |
O43242 |
PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | Homo sapiens | 29 | Detail |
P51665 |
PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | Homo sapiens | 29 | Detail |
P48556 |
PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | Homo sapiens | 29 | Detail |
O00232 |
PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | Homo sapiens | 29 | Detail |
Q15008 |
PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | Homo sapiens | 29 | Detail |
P35998 |
PSMC2 | 26S proteasome regulatory subunit 7 | Homo sapiens | 28 | Detail |
Q13200 |
PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | Homo sapiens | 28 | Detail |
P55036 |
PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | Homo sapiens | 28 | Detail |
Q9UNM6 |
PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | Homo sapiens | 28 | Detail |
P60896 |
SEM1 | 26S proteasome complex subunit SEM1 | Homo sapiens | 28 | Detail |
Q12931 |
TRAP1 | Heat shock protein 75 kDa, mitochondrial | Homo sapiens | 27 | Detail |
O95622 |
ADCY5 | Adenylate cyclase type 5 | Homo sapiens | 23 | Detail |
P05198 |
EIF2S1 | Eukaryotic translation initiation factor 2 subunit 1 | Homo sapiens | 22 | Detail |
P17861 |
XBP1 | X-box-binding protein 1 | Homo sapiens | 14 | Detail |
P62979 |
RPS27A | Ubiquitin-ribosomal protein eS31 fusion protein | Homo sapiens | 12 | Detail |
P09936 |
UCHL1 | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | Homo sapiens | 11 | Detail |
P00403 |
MT-CO2 | Cytochrome c oxidase subunit 2 | Homo sapiens | 8 | Detail |
P0DP23 |
CALM1 | Calmodulin-1 | Homo sapiens | 8 | Detail |
A6NNZ2 |
TUBB8B | Tubulin beta 8B | Homo sapiens | 7 | Detail |
O43464 |
HTRA2 | Serine protease HTRA2, mitochondrial | Homo sapiens | 6 | Detail |
P11021 |
HSPA5 | Endoplasmic reticulum chaperone BiP | Homo sapiens | 6 | Detail |
Q05940 |
SLC18A2 | Synaptic vesicular amine transporter | Homo sapiens | 6 | Detail |
O14727 |
APAF1 | Apoptotic protease-activating factor 1 | Homo sapiens | 5 | Detail |
P28562 |
DUSP1 | Dual specificity protein phosphatase 1 | Homo sapiens | 4 | Detail |
Q14643 |
ITPR1 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 | Homo sapiens | 4 | Detail |
Q14573 |
ITPR3 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 | Homo sapiens | 4 | Detail |
P03905 |
MT-ND4 | NADH-ubiquinone oxidoreductase chain 4 | Homo sapiens | 4 | Detail |
P28331 |
NDUFS1 | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | Homo sapiens | 4 | Detail |
O75306 |
NDUFS2 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitoc | Homo sapiens | 4 | Detail |
Q9P0J0 |
NDUFA13 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | Homo sapiens | 4 | Detail |
P04899 |
GNAI2 | Guanine nucleotide-binding protein G(i) subunit alpha-2 | Homo sapiens | 3 | Detail |
P12236 |
SLC25A6 | ADP/ATP translocase 3 | Homo sapiens | 3 | Detail |
Q14571 |
ITPR2 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 | Homo sapiens | 3 | Detail |
O75251 |
NDUFS7 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitoc | Homo sapiens | 3 | Detail |
P00395 |
MT-CO1 | Cytochrome c oxidase subunit 1 | Homo sapiens | 3 | Detail |
P00156 |
MT-CYB | Cytochrome b | Homo sapiens | 3 | Detail |
P03886 |
MT-ND1 | NADH-ubiquinone oxidoreductase chain 1 | Homo sapiens | 3 | Detail |
Q16718 |
NDUFA5 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | Homo sapiens | 3 | Detail |
O95299 |
NDUFA10 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | Homo sapiens | 3 | Detail |
O95169 |
NDUFB8 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, | Homo sapiens | 3 | Detail |
Q9Y6M9 |
NDUFB9 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | Homo sapiens | 3 | Detail |
O96000 |
NDUFB10 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | Homo sapiens | 3 | Detail |
O75489 |
NDUFS3 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitoc | Homo sapiens | 3 | Detail |
P19404 |
NDUFV2 | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondria | Homo sapiens | 3 | Detail |
Q9BXM7 |
PINK1 | Serine/threonine-protein kinase PINK1, mitochondrial | Homo sapiens | 3 | Detail |
O75947 |
ATP5PD | ATP synthase peripheral stalk subunit d, mitochondrial | Homo sapiens | 2 | Detail |
Q99497 |
PARK7 | Parkinson disease protein 7 | Homo sapiens | 2 | Detail |
Q86Y39 |
NDUFA11 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | Homo sapiens | 2 | Detail |
P08574 |
CYC1 | Cytochrome c1, heme protein, mitochondrial | Homo sapiens | 2 | Detail |
P08754 |
GNAI3 | Guanine nucleotide-binding protein G(i) subunit alpha-3 | Homo sapiens | 2 | Detail |
P05141 |
SLC25A5 | ADP/ATP translocase 2 | Homo sapiens | 2 | Detail |
P00846 |
MT-ATP6 | ATP synthase F(0) complex subunit a | Homo sapiens | 2 | Detail |
P03891 |
MT-ND2 | NADH-ubiquinone oxidoreductase chain 2 | Homo sapiens | 2 | Detail |
P03897 |
MT-ND3 | NADH-ubiquinone oxidoreductase chain 3 | Homo sapiens | 2 | Detail |
P03901 |
MT-ND4L | NADH-ubiquinone oxidoreductase chain 4L | Homo sapiens | 2 | Detail |
P03915 |
MT-ND5 | NADH-ubiquinone oxidoreductase chain 5 | Homo sapiens | 2 | Detail |
P03923 |
MT-ND6 | NADH-ubiquinone oxidoreductase chain 6 | Homo sapiens | 2 | Detail |
O15239 |
NDUFA1 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | Homo sapiens | 2 | Detail |
O43678 |
NDUFA2 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | Homo sapiens | 2 | Detail |
O95167 |
NDUFA3 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 | Homo sapiens | 2 | Detail |
O00483 |
COXFA4 | Cytochrome c oxidase subunit FA4 | Homo sapiens | 2 | Detail |
P56556 |
NDUFA6 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | Homo sapiens | 2 | Detail |
O95182 |
NDUFA7 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 | Homo sapiens | 2 | Detail |
P51970 |
NDUFA8 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | Homo sapiens | 2 | Detail |
Q16795 |
NDUFA9 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9 | Homo sapiens | 2 | Detail |
O14561 |
NDUFAB1 | Acyl carrier protein, mitochondrial | Homo sapiens | 2 | Detail |
O75438 |
NDUFB1 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 | Homo sapiens | 2 | Detail |
O95178 |
NDUFB2 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, | Homo sapiens | 2 | Detail |
O43676 |
NDUFB3 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | Homo sapiens | 2 | Detail |
O95168 |
NDUFB4 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 | Homo sapiens | 2 | Detail |
O43674 |
NDUFB5 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, | Homo sapiens | 2 | Detail |
O95139 |
NDUFB6 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | Homo sapiens | 2 | Detail |
P17568 |
NDUFB7 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | Homo sapiens | 2 | Detail |
O43677 |
NDUFC1 | NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial | Homo sapiens | 2 | Detail |
O95298 |
NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | Homo sapiens | 2 | Detail |
P49821 |
NDUFV1 | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondria | Homo sapiens | 2 | Detail |
O43181 |
NDUFS4 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitoc | Homo sapiens | 2 | Detail |
O43920 |
NDUFS5 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 | Homo sapiens | 2 | Detail |
O75380 |
NDUFS6 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitoc | Homo sapiens | 2 | Detail |
O00217 |
NDUFS8 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitoc | Homo sapiens | 2 | Detail |
P56181 |
NDUFV3 | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondria | Homo sapiens | 2 | Detail |
Q9NY65 |
TUBA8 | Tubulin alpha-8 chain | Homo sapiens | 2 | Detail |
P19174 |
PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase ga | Homo sapiens | 2 | Detail |
Q9NX14 |
NDUFB11 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11 | Homo sapiens | 2 | Detail |
Q9UI09 |
NDUFA12 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | Homo sapiens | 2 | Detail |
Q9NRX3 |
COXFA4L2 | Cytochrome c oxidase hypoxia associated subunit FA4L2 | Homo sapiens | 2 | Detail |
P22695 |
UQCRC2 | Cytochrome b-c1 complex subunit 2, mitochondrial | Homo sapiens | 2 | Detail |
P21796 |
VDAC1 | Non-selective voltage-gated ion channel VDAC1 | Homo sapiens | 2 | Detail |
Q9Y277 |
VDAC3 | Non-selective voltage-gated ion channel VDAC3 | Homo sapiens | 2 | Detail |
A6NHL2 |
TUBAL3 | Tubulin alpha chain-like 3 | Homo sapiens | 2 | Detail |
P13073 |
COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | Homo sapiens | 1 | Detail |
P12074 |
COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | Homo sapiens | 1 | Detail |
P09669 |
COX6C | Cytochrome c oxidase subunit 6C | Homo sapiens | 1 | Detail |
Q15043 |
SLC39A14 | Metal cation symporter ZIP14 | Homo sapiens | 1 | Detail |
Q9BRY0 |
SLC39A3 | Zinc transporter ZIP3 | Homo sapiens | 1 | Detail |
P49281 |
SLC11A2 | Natural resistance-associated macrophage protein 2 | Homo sapiens | 1 | Detail |
P06576 |
ATP5F1B | ATP synthase F(1) complex subunit beta, mitochondrial | Homo sapiens | 1 | Detail |
P24539 |
ATP5PB | ATP synthase peripheral stalk subunit b, mitochondrial | Homo sapiens | 1 | Detail |
P48047 |
ATP5PO | ATP synthase peripheral stalk subunit OSCP, mitochondrial | Homo sapiens | 1 | Detail |
P99999 |
CYCS | Cytochrome c | Homo sapiens | 1 | Detail |
O00233 |
PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | Homo sapiens | 1 | Detail |
Q07812 |
BAX | Apoptosis regulator BAX | Homo sapiens | 1 | Detail |
P31040 |
SDHA | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, m | Homo sapiens | 1 | Detail |
P07101 |
TH | Tyrosine 3-monooxygenase | Homo sapiens | 1 | Detail |
P60604 |
UBE2G2 | Ubiquitin-conjugating enzyme E2 G2 | Homo sapiens | 1 | Detail |
P68036 |
UBE2L3 | Ubiquitin-conjugating enzyme E2 L3 | Homo sapiens | 1 | Detail |
P31930 |
UQCRC1 | Cytochrome b-c1 complex subunit 1, mitochondrial | Homo sapiens | 1 | Detail |
P45880 |
VDAC2 | Non-selective voltage-gated ion channel VDAC2 | Homo sapiens | 1 | Detail |
Q92504 |
SLC39A7 | Zinc transporter SLC39A7 | Homo sapiens | 1 | Detail |
Q8NE86 |
MCU | Calcium uniporter protein, mitochondrial | Homo sapiens | 1 | Detail |