AGE-RAGE signaling pathway in diabetic complications
hsa04933 71 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
O60674 |
JAK2 | Tyrosine-protein kinase JAK2 | Homo sapiens | 10545 | Detail |
P42336 |
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 5616 | Detail |
O00329 |
PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 3772 | Detail |
P11802 |
CDK4 | Cyclin-dependent kinase 4 | Homo sapiens | 2896 | Detail |
P08253 |
MMP2 | 72 kDa type IV collagenase | Homo sapiens | 2719 | Detail |
P11309 |
PIM1 | Serine/threonine-protein kinase pim-1 | Homo sapiens | 2647 | Detail |
P27986 |
PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | Homo sapiens | 2553 | Detail |
P42338 |
PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 1951 | Detail |
P01116 |
KRAS | GTPase KRas | Homo sapiens | 1811 | Detail |
Q16539 |
MAPK14 | Mitogen-activated protein kinase 14 | Homo sapiens | 1754 | Detail |
P24385 |
CCND1 | G1/S-specific cyclin-D1 | Homo sapiens | 1643 | Detail |
P31749 |
AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens | 1633 | Detail |
P10415 |
BCL2 | Apoptosis regulator Bcl-2 | Homo sapiens | 1065 | Detail |
P01111 |
NRAS | GTPase NRas | Homo sapiens | 923 | Detail |
P28482 |
MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens | 906 | Detail |
P31751 |
AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens | 896 | Detail |
P45983 |
MAPK8 | Mitogen-activated protein kinase 8 | Homo sapiens | 748 | Detail |
Q05655 |
PRKCD | Protein kinase C delta type | Homo sapiens | 742 | Detail |
P30556 |
AGTR1 | Type-1 angiotensin II receptor | Homo sapiens | 696 | Detail |
P17252 |
PRKCA | Protein kinase C alpha type | Homo sapiens | 679 | Detail |
P45984 |
MAPK9 | Mitogen-activated protein kinase 9 | Homo sapiens | 676 | Detail |
P53779 |
MAPK10 | Mitogen-activated protein kinase 10 | Homo sapiens | 625 | Detail |
P53778 |
MAPK12 | Mitogen-activated protein kinase 12 | Homo sapiens | 606 | Detail |
Q15759 |
MAPK11 | Mitogen-activated protein kinase 11 | Homo sapiens | 594 | Detail |
O15264 |
MAPK13 | Mitogen-activated protein kinase 13 | Homo sapiens | 533 | Detail |
O00459 |
PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | Homo sapiens | 485 | Detail |
P05362 |
ICAM1 | Intercellular adhesion molecule 1 | Homo sapiens | 462 | Detail |
P05771 |
PRKCB | Protein kinase C beta type | Homo sapiens | 457 | Detail |
P42574 |
CASP3 | Caspase-3 | Homo sapiens | 444 | Detail |
P36897 |
TGFBR1 | TGF-beta receptor type-1 | Homo sapiens | 428 | Detail |
Q02156 |
PRKCE | Protein kinase C epsilon type | Homo sapiens | 423 | Detail |
P13726 |
F3 | Tissue factor | Homo sapiens | 380 | Detail |
Q9Y243 |
AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens | 321 | Detail |
Q92569 |
PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | Homo sapiens | 289 | Detail |
P27361 |
MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens | 234 | Detail |
Q05513 |
PRKCZ | Protein kinase C zeta type | Homo sapiens | 166 | Detail |
P01584 |
IL1B | Interleukin-1 beta | Homo sapiens | 148 | Detail |
P37173 |
TGFBR2 | TGF-beta receptor type-2 | Homo sapiens | 144 | Detail |
P01375 |
TNF | Tumor necrosis factor | Homo sapiens | 144 | Detail |
P19838 |
NFKB1 | Nuclear factor NF-kappa-B p105 subunit | Homo sapiens | 140 | Detail |
Q04206 |
RELA | Transcription factor p65 | Homo sapiens | 134 | Detail |
P16581 |
SELE | E-selectin | Homo sapiens | 99 | Detail |
P29474 |
NOS3 | Nitric oxide synthase 3 | Homo sapiens | 94 | Detail |
P05412 |
JUN | Transcription factor Jun | Homo sapiens | 69 | Detail |
P13500 |
CCL2 | C-C motif chemokine 2 | Homo sapiens | 65 | Detail |
P19320 |
VCAM1 | Vascular cell adhesion protein 1 | Homo sapiens | 64 | Detail |
P40763 |
STAT3 | Signal transducer and activator of transcription 3 | Homo sapiens | 49 | Detail |
P15692 |
VEGFA | Vascular endothelial growth factor A, long form | Homo sapiens | 44 | Detail |
P05231 |
IL6 | Interleukin-6 | Homo sapiens | 17 | Detail |
P60953 |
CDC42 | Cell division control protein 42 homolog | Homo sapiens | 16 | Detail |
P01112 |
HRAS | GTPase HRas | Homo sapiens | 14 | Detail |
P84022 |
SMAD3 | SMAD family member 3 | Homo sapiens | 11 | Detail |
P42229 |
STAT5A | Signal transducer and activator of transcription 5A | Homo sapiens | 11 | Detail |
Q15796 |
SMAD2 | SMAD family member 2 | Homo sapiens | 10 | Detail |
P10145 |
CXCL8 | Interleukin-8 | Homo sapiens | 9 | Detail |
Q9NPH5 |
NOX4 | NADPH oxidase 4 | Homo sapiens | 8 | Detail |
P01137 |
TGFB1 | Transforming growth factor beta-1 proprotein | Homo sapiens | 8 | Detail |
P04839 |
CYBB | NADPH oxidase 2 | Homo sapiens | 6 | Detail |
Q9Y5S8 |
NOX1 | NADPH oxidase 1 | Homo sapiens | 5 | Detail |
P51692 |
STAT5B | Signal transducer and activator of transcription 5B | Homo sapiens | 5 | Detail |
P42224 |
STAT1 | Signal transducer and activator of transcription 1-alpha/bet | Homo sapiens | 4 | Detail |
P02751 |
FN1 | Fibronectin | Homo sapiens | 3 | Detail |
P63000 |
RAC1 | Ras-related C3 botulinum toxin substrate 1 | Homo sapiens | 3 | Detail |
P19174 |
PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase ga | Homo sapiens | 2 | Detail |
P16885 |
PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase ga | Homo sapiens | 2 | Detail |
P61812 |
TGFB2 | Transforming growth factor beta-2 proprotein | Homo sapiens | 2 | Detail |
O60610 |
DIAPH1 | Protein diaphanous homolog 1 | Homo sapiens | 1 | Detail |
Q15109 |
AGER | Advanced glycosylation end product-specific receptor | Homo sapiens | 1 | Detail |
Q07812 |
BAX | Apoptosis regulator BAX | Homo sapiens | 1 | Detail |
P01019 |
AGT | Angiotensinogen | Homo sapiens | 0 | Detail |
P51178 |
PLCD1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase de | Homo sapiens | 0 | Detail |