Non-alcoholic fatty liver disease

hsa04932 110 targets in this pathway

UniProt AC Gene Protein Name Organism Multi-Target Molecules
P42336 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub Homo sapiens 5616 Detail
O00329 PIK3CD Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub Homo sapiens 3772 Detail
P27986 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha Homo sapiens 2553 Detail
P49841 GSK3B Glycogen synthase kinase-3 beta Homo sapiens 2206 Detail
P42338 PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub Homo sapiens 1951 Detail
O43521 BCL2L11 Bcl-2-like protein 11 Homo sapiens 1888 Detail
Q16539 MAPK14 Mitogen-activated protein kinase 14 Homo sapiens 1754 Detail
P31749 AKT1 RAC-alpha serine/threonine-protein kinase Homo sapiens 1633 Detail
P49840 GSK3A Glycogen synthase kinase-3 alpha Homo sapiens 1262 Detail
P31751 AKT2 RAC-beta serine/threonine-protein kinase Homo sapiens 896 Detail
P45983 MAPK8 Mitogen-activated protein kinase 8 Homo sapiens 748 Detail
P19793 RXRA Retinoic acid receptor RXR-alpha Homo sapiens 702 Detail
P45984 MAPK9 Mitogen-activated protein kinase 9 Homo sapiens 676 Detail
P06213 INSR Insulin receptor Homo sapiens 656 Detail
P53779 MAPK10 Mitogen-activated protein kinase 10 Homo sapiens 625 Detail
P53778 MAPK12 Mitogen-activated protein kinase 12 Homo sapiens 606 Detail
Q15759 MAPK11 Mitogen-activated protein kinase 11 Homo sapiens 594 Detail
O15264 MAPK13 Mitogen-activated protein kinase 13 Homo sapiens 533 Detail
O00459 PIK3R2 Phosphatidylinositol 3-kinase regulatory subunit beta Homo sapiens 485 Detail
P42574 CASP3 Caspase-3 Homo sapiens 444 Detail
Q13133 NR1H3 Oxysterols receptor LXR-alpha Homo sapiens 422 Detail
P37231 PPARG Peroxisome proliferator-activated receptor gamma Homo sapiens 417 Detail
O14920 IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta Homo sapiens 411 Detail
Q07869 PPARA Peroxisome proliferator-activated receptor alpha Homo sapiens 355 Detail
Q9Y243 AKT3 RAC-gamma serine/threonine-protein kinase Homo sapiens 321 Detail
P55210 CASP7 Caspase-7 Homo sapiens 306 Detail
Q92569 PIK3R3 Phosphatidylinositol 3-kinase regulatory subunit gamma Homo sapiens 289 Detail
Q13131 PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens 282 Detail
Q14790 CASP8 Caspase-8 Homo sapiens 219 Detail
Q9NZJ5 EIF2AK3 Eukaryotic translation initiation factor 2-alpha kinase 3 Homo sapiens 154 Detail
P01584 IL1B Interleukin-1 beta Homo sapiens 148 Detail
P01375 TNF Tumor necrosis factor Homo sapiens 144 Detail
P19838 NFKB1 Nuclear factor NF-kappa-B p105 subunit Homo sapiens 140 Detail
Q04206 RELA Transcription factor p65 Homo sapiens 134 Detail
P54619 PRKAG1 5'-AMP-activated protein kinase subunit gamma-1 Homo sapiens 83 Detail
Q99683 MAP3K5 Mitogen-activated protein kinase kinase kinase 5 Homo sapiens 81 Detail
Q16584 MAP3K11 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 79 Detail
P54646 PRKAA2 5'-AMP-activated protein kinase catalytic subunit alpha-2 Homo sapiens 75 Detail
P05412 JUN Transcription factor Jun Homo sapiens 69 Detail
Q9Y478 PRKAB1 5'-AMP-activated protein kinase subunit beta-1 Homo sapiens 65 Detail
O75460 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens 46 Detail
O43741 PRKAB2 5'-AMP-activated protein kinase subunit beta-2 Homo sapiens 45 Detail
Q9UGJ0 PRKAG2 5'-AMP-activated protein kinase subunit gamma-2 Homo sapiens 44 Detail
P55957 BID BH3-interacting domain death agonist Homo sapiens 41 Detail
Q9UGI9 PRKAG3 5'-AMP-activated protein kinase subunit gamma-3 Homo sapiens 30 Detail
P01100 FOS Protein c-Fos Homo sapiens 25 Detail
P05198 EIF2S1 Eukaryotic translation initiation factor 2 subunit 1 Homo sapiens 22 Detail
P05231 IL6 Interleukin-6 Homo sapiens 17 Detail
P05181 CYP2E1 Cytochrome P450 2E1 Homo sapiens 16 Detail
P60953 CDC42 Cell division control protein 42 homolog Homo sapiens 16 Detail
P17861 XBP1 X-box-binding protein 1 Homo sapiens 14 Detail
P10145 CXCL8 Interleukin-8 Homo sapiens 9 Detail
P00403 MT-CO2 Cytochrome c oxidase subunit 2 Homo sapiens 8 Detail
P01137 TGFB1 Transforming growth factor beta-1 proprotein Homo sapiens 8 Detail
Q9UH92 MLX Max-like protein X Homo sapiens 7 Detail
P28331 NDUFS1 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial Homo sapiens 4 Detail
O75306 NDUFS2 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitoc Homo sapiens 4 Detail
Q9P0J0 NDUFA13 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Homo sapiens 4 Detail
O75251 NDUFS7 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitoc Homo sapiens 3 Detail
P00395 MT-CO1 Cytochrome c oxidase subunit 1 Homo sapiens 3 Detail
P00156 MT-CYB Cytochrome b Homo sapiens 3 Detail
Q16718 NDUFA5 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 Homo sapiens 3 Detail
O95299 NDUFA10 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Homo sapiens 3 Detail
O95169 NDUFB8 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, Homo sapiens 3 Detail
Q9Y6M9 NDUFB9 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 Homo sapiens 3 Detail
O96000 NDUFB10 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 Homo sapiens 3 Detail
O75489 NDUFS3 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitoc Homo sapiens 3 Detail
P19404 NDUFV2 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondria Homo sapiens 3 Detail
P63000 RAC1 Ras-related C3 botulinum toxin substrate 1 Homo sapiens 3 Detail
Q86Y39 NDUFA11 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Homo sapiens 2 Detail
P08574 CYC1 Cytochrome c1, heme protein, mitochondrial Homo sapiens 2 Detail
P35568 IRS1 Insulin receptor substrate 1 Homo sapiens 2 Detail
O15239 NDUFA1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Homo sapiens 2 Detail
O43678 NDUFA2 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 Homo sapiens 2 Detail
O95167 NDUFA3 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 Homo sapiens 2 Detail
O00483 COXFA4 Cytochrome c oxidase subunit FA4 Homo sapiens 2 Detail
P56556 NDUFA6 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 Homo sapiens 2 Detail
O95182 NDUFA7 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 Homo sapiens 2 Detail
P51970 NDUFA8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 Homo sapiens 2 Detail
Q16795 NDUFA9 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9 Homo sapiens 2 Detail
O14561 NDUFAB1 Acyl carrier protein, mitochondrial Homo sapiens 2 Detail
O75438 NDUFB1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 Homo sapiens 2 Detail
O95178 NDUFB2 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, Homo sapiens 2 Detail
O43676 NDUFB3 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 Homo sapiens 2 Detail
O95168 NDUFB4 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 Homo sapiens 2 Detail
O43674 NDUFB5 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, Homo sapiens 2 Detail
O95139 NDUFB6 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 Homo sapiens 2 Detail
P17568 NDUFB7 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 Homo sapiens 2 Detail
O43677 NDUFC1 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial Homo sapiens 2 Detail
O95298 NDUFC2 NADH dehydrogenase [ubiquinone] 1 subunit C2 Homo sapiens 2 Detail
P49821 NDUFV1 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondria Homo sapiens 2 Detail
O43181 NDUFS4 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitoc Homo sapiens 2 Detail
O43920 NDUFS5 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 Homo sapiens 2 Detail
O75380 NDUFS6 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitoc Homo sapiens 2 Detail
O00217 NDUFS8 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitoc Homo sapiens 2 Detail
P56181 NDUFV3 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondria Homo sapiens 2 Detail
Q9NX14 NDUFB11 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11 Homo sapiens 2 Detail
Q9UI09 NDUFA12 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Homo sapiens 2 Detail
Q9NRX3 COXFA4L2 Cytochrome c oxidase hypoxia associated subunit FA4L2 Homo sapiens 2 Detail
P19438 TNFRSF1A Tumor necrosis factor receptor superfamily member 1A Homo sapiens 2 Detail
P22695 UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial Homo sapiens 2 Detail
P13073 COX4I1 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Homo sapiens 1 Detail
P12074 COX6A1 Cytochrome c oxidase subunit 6A1, mitochondrial Homo sapiens 1 Detail
P09669 COX6C Cytochrome c oxidase subunit 6C Homo sapiens 1 Detail
P99999 CYCS Cytochrome c Homo sapiens 1 Detail
Q07812 BAX Apoptosis regulator BAX Homo sapiens 1 Detail
P31040 SDHA Succinate dehydrogenase [ubiquinone] flavoprotein subunit, m Homo sapiens 1 Detail
P36956 SREBF1 Sterol regulatory element-binding protein 1 Homo sapiens 1 Detail
Q12933 TRAF2 TNF receptor-associated factor 2 Homo sapiens 1 Detail
P31930 UQCRC1 Cytochrome b-c1 complex subunit 1, mitochondrial Homo sapiens 1 Detail