Insulin signaling pathway
hsa04910 84 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
P42336 |
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 5616 | Detail |
O00329 |
PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 3772 | Detail |
P15056 |
BRAF | Serine/threonine-protein kinase B-raf | Homo sapiens | 2643 | Detail |
P27986 |
PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | Homo sapiens | 2553 | Detail |
P42345 |
MTOR | Serine/threonine-protein kinase mTOR | Homo sapiens | 2517 | Detail |
P49841 |
GSK3B | Glycogen synthase kinase-3 beta | Homo sapiens | 2206 | Detail |
P04049 |
RAF1 | RAF proto-oncogene serine/threonine-protein kinase | Homo sapiens | 2133 | Detail |
P42338 |
PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 1951 | Detail |
P01116 |
KRAS | GTPase KRas | Homo sapiens | 1811 | Detail |
P31749 |
AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens | 1633 | Detail |
P23443 |
RPS6KB1 | Ribosomal protein S6 kinase beta-1 | Homo sapiens | 1180 | Detail |
Q13370 |
PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B | Homo sapiens | 936 | Detail |
P01111 |
NRAS | GTPase NRas | Homo sapiens | 923 | Detail |
P28482 |
MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens | 906 | Detail |
P31751 |
AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens | 896 | Detail |
Q07889 |
SOS1 | Son of sevenless homolog 1 | Homo sapiens | 766 | Detail |
P45983 |
MAPK8 | Mitogen-activated protein kinase 8 | Homo sapiens | 748 | Detail |
Q13191 |
CBLB | E3 ubiquitin-protein ligase CBL-B | Homo sapiens | 746 | Detail |
P45984 |
MAPK9 | Mitogen-activated protein kinase 9 | Homo sapiens | 676 | Detail |
P06213 |
INSR | Insulin receptor | Homo sapiens | 656 | Detail |
P53779 |
MAPK10 | Mitogen-activated protein kinase 10 | Homo sapiens | 625 | Detail |
Q9HBH9 |
MKNK2 | MAP kinase-interacting serine/threonine-protein kinase 2 | Homo sapiens | 608 | Detail |
Q02750 |
MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens | 543 | Detail |
P18031 |
PTPN1 | Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens | 511 | Detail |
O00459 |
PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | Homo sapiens | 485 | Detail |
P17612 |
PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | Homo sapiens | 453 | Detail |
Q9BUB5 |
MKNK1 | MAP kinase-interacting serine/threonine-protein kinase 1 | Homo sapiens | 445 | Detail |
O14920 |
IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | Homo sapiens | 411 | Detail |
Q13085 |
ACACA | Acetyl-CoA carboxylase 1 | Homo sapiens | 406 | Detail |
O00763 |
ACACB | Acetyl-CoA carboxylase 2 | Homo sapiens | 401 | Detail |
Q13541 |
EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein | Homo sapiens | 358 | Detail |
Q9Y243 |
AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens | 321 | Detail |
Q92569 |
PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | Homo sapiens | 289 | Detail |
Q13131 |
PRKAA1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | Homo sapiens | 282 | Detail |
P27361 |
MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens | 234 | Detail |
O15530 |
PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | Homo sapiens | 228 | Detail |
Q8N122 |
RPTOR | Regulatory-associated protein of mTOR | Homo sapiens | 189 | Detail |
Q05513 |
PRKCZ | Protein kinase C zeta type | Homo sapiens | 166 | Detail |
P41743 |
PRKCI | Protein kinase C iota type | Homo sapiens | 158 | Detail |
P36507 |
MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | Homo sapiens | 146 | Detail |
P22694 |
PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Homo sapiens | 121 | Detail |
P22612 |
PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | Homo sapiens | 111 | Detail |
P54619 |
PRKAG1 | 5'-AMP-activated protein kinase subunit gamma-1 | Homo sapiens | 83 | Detail |
P15735 |
PHKG2 | Phosphorylase b kinase gamma catalytic chain, liver/testis i | Homo sapiens | 76 | Detail |
P54646 |
PRKAA2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | Homo sapiens | 75 | Detail |
P06737 |
PYGL | Glycogen phosphorylase, liver form | Homo sapiens | 70 | Detail |
Q9Y478 |
PRKAB1 | 5'-AMP-activated protein kinase subunit beta-1 | Homo sapiens | 65 | Detail |
P49327 |
FASN | Fatty acid synthase | Homo sapiens | 64 | Detail |
P11217 |
PYGM | Glycogen phosphorylase, muscle form | Homo sapiens | 58 | Detail |
O14492 |
SH2B2 | SH2B adapter protein 2 | Homo sapiens | 50 | Detail |
P06730 |
EIF4E | Eukaryotic translation initiation factor 4E | Homo sapiens | 46 | Detail |
O43741 |
PRKAB2 | 5'-AMP-activated protein kinase subunit beta-2 | Homo sapiens | 45 | Detail |
Q9UGJ0 |
PRKAG2 | 5'-AMP-activated protein kinase subunit gamma-2 | Homo sapiens | 44 | Detail |
P14672 |
SLC2A4 | Solute carrier family 2, facilitated glucose transporter mem | Homo sapiens | 40 | Detail |
P35557 |
GCK | Hexokinase-4 | Homo sapiens | 39 | Detail |
P10398 |
ARAF | Serine/threonine-protein kinase A-Raf | Homo sapiens | 37 | Detail |
Q9UGI9 |
PRKAG3 | 5'-AMP-activated protein kinase subunit gamma-3 | Homo sapiens | 30 | Detail |
Q92934 |
BAD | Bcl2-associated agonist of cell death | Homo sapiens | 27 | Detail |
Q16816 |
PHKG1 | Phosphorylase b kinase gamma catalytic chain, skeletal muscl | Homo sapiens | 23 | Detail |
P22681 |
CBL | E3 ubiquitin-protein ligase CBL | Homo sapiens | 16 | Detail |
P01112 |
HRAS | GTPase HRas | Homo sapiens | 14 | Detail |
O15357 |
INPPL1 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 | Homo sapiens | 14 | Detail |
Q05469 |
LIPE | Hormone-sensitive lipase | Homo sapiens | 13 | Detail |
P62753 |
RPS6 | Small ribosomal subunit protein eS6 | Homo sapiens | 13 | Detail |
Q9UBS0 |
RPS6KB2 | Ribosomal protein S6 kinase beta-2 | Homo sapiens | 13 | Detail |
P09467 |
FBP1 | Fructose-1,6-bisphosphatase 1 | Homo sapiens | 12 | Detail |
P19367 |
HK1 | Hexokinase-1 | Homo sapiens | 12 | Detail |
P52789 |
HK2 | Hexokinase-2 | Homo sapiens | 11 | Detail |
P13861 |
PRKAR2A | cAMP-dependent protein kinase type II-alpha regulatory subun | Homo sapiens | 9 | Detail |
P10586 |
PTPRF | Receptor-type tyrosine-protein phosphatase F | Homo sapiens | 9 | Detail |
P0DP23 |
CALM1 | Calmodulin-1 | Homo sapiens | 8 | Detail |
P31323 |
PRKAR2B | cAMP-dependent protein kinase type II-beta regulatory subuni | Homo sapiens | 7 | Detail |
P36873 |
PPP1CC | Serine/threonine-protein phosphatase PP1-gamma catalytic sub | Homo sapiens | 5 | Detail |
P62993 |
GRB2 | Growth factor receptor-bound protein 2 | Homo sapiens | 4 | Detail |
P46019 |
PHKA2 | Phosphorylase b kinase regulatory subunit alpha, liver isofo | Homo sapiens | 3 | Detail |
Q93100 |
PHKB | Phosphorylase b kinase regulatory subunit beta | Homo sapiens | 3 | Detail |
P35568 |
IRS1 | Insulin receptor substrate 1 | Homo sapiens | 2 | Detail |
Q16822 |
PCK2 | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial | Homo sapiens | 2 | Detail |
P46020 |
PHKA1 | Phosphorylase b kinase regulatory subunit alpha, skeletal mu | Homo sapiens | 2 | Detail |
P62136 |
PPP1CA | Serine/threonine-protein phosphatase PP1-alpha catalytic sub | Homo sapiens | 2 | Detail |
O75955 |
FLOT1 | Flotillin-1 | Homo sapiens | 1 | Detail |
P46109 |
CRKL | Crk-like protein | Homo sapiens | 1 | Detail |
P11216 |
PYGB | Glycogen phosphorylase, brain form | Homo sapiens | 1 | Detail |
P36956 |
SREBF1 | Sterol regulatory element-binding protein 1 | Homo sapiens | 1 | Detail |