Regulation of actin cytoskeleton
hsa04810 120 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
P42336 |
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 5616 | Detail |
O00329 |
PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 3772 | Detail |
P00533 |
EGFR | Epidermal growth factor receptor | Homo sapiens | 3433 | Detail |
P11362 |
FGFR1 | Fibroblast growth factor receptor 1 | Homo sapiens | 3320 | Detail |
P22607 |
FGFR3 | Fibroblast growth factor receptor 3 | Homo sapiens | 2742 | Detail |
P15056 |
BRAF | Serine/threonine-protein kinase B-raf | Homo sapiens | 2643 | Detail |
P27986 |
PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | Homo sapiens | 2553 | Detail |
P05106 |
ITGB3 | Integrin beta-3 | Homo sapiens | 2474 | Detail |
P04049 |
RAF1 | RAF proto-oncogene serine/threonine-protein kinase | Homo sapiens | 2133 | Detail |
P21802 |
FGFR2 | Fibroblast growth factor receptor 2 | Homo sapiens | 2130 | Detail |
P12931 |
SRC | Proto-oncogene tyrosine-protein kinase Src | Homo sapiens | 1978 | Detail |
P42338 |
PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 1951 | Detail |
P01116 |
KRAS | GTPase KRas | Homo sapiens | 1811 | Detail |
O75116 |
ROCK2 | Rho-associated protein kinase 2 | Homo sapiens | 1696 | Detail |
P08172 |
CHRM2 | Muscarinic acetylcholine receptor M2 | Homo sapiens | 1645 | Detail |
P31749 |
AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens | 1633 | Detail |
P06756 |
ITGAV | Integrin alpha-V | Homo sapiens | 1632 | Detail |
Q13464 |
ROCK1 | Rho-associated protein kinase 1 | Homo sapiens | 1614 | Detail |
P05556 |
ITGB1 | Integrin beta-1 | Homo sapiens | 1572 | Detail |
P11229 |
CHRM1 | Muscarinic acetylcholine receptor M1 | Homo sapiens | 1571 | Detail |
P09619 |
PDGFRB | Platelet-derived growth factor receptor beta | Homo sapiens | 1527 | Detail |
P22455 |
FGFR4 | Fibroblast growth factor receptor 4 | Homo sapiens | 1506 | Detail |
P20309 |
CHRM3 | Muscarinic acetylcholine receptor M3 | Homo sapiens | 1440 | Detail |
P08514 |
ITGA2B | Integrin alpha-IIb | Homo sapiens | 1322 | Detail |
P13612 |
ITGA4 | Integrin alpha-4 | Homo sapiens | 1260 | Detail |
P00734 |
F2 | Prothrombin | Homo sapiens | 1259 | Detail |
P01111 |
NRAS | GTPase NRas | Homo sapiens | 923 | Detail |
P28482 |
MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens | 906 | Detail |
P31751 |
AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens | 896 | Detail |
P16234 |
PDGFRA | Platelet-derived growth factor receptor alpha | Homo sapiens | 860 | Detail |
Q07889 |
SOS1 | Son of sevenless homolog 1 | Homo sapiens | 766 | Detail |
P08173 |
CHRM4 | Muscarinic acetylcholine receptor M4 | Homo sapiens | 686 | Detail |
P08912 |
CHRM5 | Muscarinic acetylcholine receptor M5 | Homo sapiens | 585 | Detail |
Q02750 |
MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens | 543 | Detail |
O00459 |
PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | Homo sapiens | 485 | Detail |
P18564 |
ITGB6 | Integrin beta-6 | Homo sapiens | 451 | Detail |
P18084 |
ITGB5 | Integrin beta-5 | Homo sapiens | 402 | Detail |
P05107 |
ITGB2 | Integrin beta-2 | Homo sapiens | 373 | Detail |
P20701 |
ITGAL | Integrin alpha-L | Homo sapiens | 369 | Detail |
P08648 |
ITGA5 | Integrin alpha-5 | Homo sapiens | 366 | Detail |
P53667 |
LIMK1 | LIM domain kinase 1 | Homo sapiens | 364 | Detail |
P26010 |
ITGB7 | Integrin beta-7 | Homo sapiens | 355 | Detail |
Q05397 |
PTK2 | Focal adhesion kinase 1 | Homo sapiens | 325 | Detail |
Q9Y243 |
AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens | 321 | Detail |
Q92569 |
PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | Homo sapiens | 289 | Detail |
P27361 |
MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens | 234 | Detail |
P53671 |
LIMK2 | LIM domain kinase 2 | Homo sapiens | 219 | Detail |
O96013 |
PAK4 | Serine/threonine-protein kinase PAK 4 | Homo sapiens | 189 | Detail |
P26012 |
ITGB8 | Integrin beta-8 | Homo sapiens | 163 | Detail |
P36507 |
MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | Homo sapiens | 146 | Detail |
Q92633 |
LPAR1 | Lysophosphatidic acid receptor 1 | Homo sapiens | 122 | Detail |
Q13153 |
PAK1 | Serine/threonine-protein kinase PAK 1 | Homo sapiens | 107 | Detail |
P46663 |
BDKRB1 | B1 bradykinin receptor | Homo sapiens | 88 | Detail |
Q9H1C0 |
LPAR5 | Lysophosphatidic acid receptor 5 | Homo sapiens | 80 | Detail |
P09038 |
FGF2 | Fibroblast growth factor 2 | Homo sapiens | 69 | Detail |
P17301 |
ITGA2 | Integrin alpha-2 | Homo sapiens | 65 | Detail |
P01042 |
KNG1 | Kininogen-1 | Homo sapiens | 59 | Detail |
P61073 |
CXCR4 | C-X-C chemokine receptor type 4 | Homo sapiens | 57 | Detail |
Q13177 |
PAK2 | Serine/threonine-protein kinase PAK 2 | Homo sapiens | 47 | Detail |
Q8TBX8 |
PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Homo sapiens | 46 | Detail |
P05230 |
FGF1 | Fibroblast growth factor 1 | Homo sapiens | 45 | Detail |
Q86YV6 |
MYLK4 | Myosin light chain kinase family member 4 | Homo sapiens | 43 | Detail |
Q15746 |
MYLK | Myosin light chain kinase, smooth muscle | Homo sapiens | 42 | Detail |
P25116 |
F2R | Proteinase-activated receptor 1 | Homo sapiens | 37 | Detail |
P10398 |
ARAF | Serine/threonine-protein kinase A-Raf | Homo sapiens | 37 | Detail |
O75914 |
PAK3 | Serine/threonine-protein kinase PAK 3 | Homo sapiens | 35 | Detail |
Q9HBW0 |
LPAR2 | Lysophosphatidic acid receptor 2 | Homo sapiens | 33 | Detail |
P30411 |
BDKRB2 | B2 bradykinin receptor | Homo sapiens | 32 | Detail |
Q32MK0 |
MYLK3 | Myosin light chain kinase 3 | Homo sapiens | 27 | Detail |
P48426 |
PIP4K2A | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | Homo sapiens | 26 | Detail |
Q9P286 |
PAK5 | Serine/threonine-protein kinase PAK 5 | Homo sapiens | 23 | Detail |
Q9H1R3 |
MYLK2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Homo sapiens | 22 | Detail |
Q9NQU5 |
PAK6 | Serine/threonine-protein kinase PAK 6 | Homo sapiens | 21 | Detail |
P53708 |
ITGA8 | Integrin alpha-8 | Homo sapiens | 21 | Detail |
Q99755 |
PIP5K1A | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha | Homo sapiens | 20 | Detail |
P14616 |
INSRR | Insulin receptor-related protein | Homo sapiens | 17 | Detail |
P01127 |
PDGFB | Platelet-derived growth factor subunit B | Homo sapiens | 16 | Detail |
P60953 |
CDC42 | Cell division control protein 42 homolog | Homo sapiens | 16 | Detail |
P01112 |
HRAS | GTPase HRas | Homo sapiens | 14 | Detail |
P78356 |
PIP4K2B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | Homo sapiens | 14 | Detail |
O60331 |
PIP5K1C | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma | Homo sapiens | 13 | Detail |
P19634 |
SLC9A1 | Sodium/hydrogen exchanger 1 | Homo sapiens | 10 | Detail |
Q9Y2I7 |
PIKFYVE | 1-phosphatidylinositol 3-phosphate 5-kinase | Homo sapiens | 6 | Detail |
P25054 |
APC | Adenomatous polyposis coli protein | Homo sapiens | 6 | Detail |
P56199 |
ITGA1 | Integrin alpha-1 | Homo sapiens | 6 | Detail |
P01031 |
C5 | Complement C5 | Homo sapiens | 6 | Detail |
P36873 |
PPP1CC | Serine/threonine-protein phosphatase PP1-gamma catalytic sub | Homo sapiens | 5 | Detail |
P48061 |
CXCL12 | Stromal cell-derived factor 1 | Homo sapiens | 4 | Detail |
O14986 |
PIP5K1B | Phosphatidylinositol 4-phosphate 5-kinase type-1 beta | Homo sapiens | 4 | Detail |
P02751 |
FN1 | Fibronectin | Homo sapiens | 3 | Detail |
P63000 |
RAC1 | Ras-related C3 botulinum toxin substrate 1 | Homo sapiens | 3 | Detail |
P15153 |
RAC2 | Ras-related C3 botulinum toxin substrate 2 | Homo sapiens | 3 | Detail |
P61158 |
ACTR3 | Actin-related protein 3 | Homo sapiens | 2 | Detail |
P61160 |
ACTR2 | Actin-related protein 2 | Homo sapiens | 2 | Detail |
Q99677 |
LPAR4 | Lysophosphatidic acid receptor 4 | Homo sapiens | 2 | Detail |
P11215 |
ITGAM | Integrin alpha-M | Homo sapiens | 2 | Detail |
P35579 |
MYH9 | Myosin-9 | Homo sapiens | 2 | Detail |
P35580 |
MYH10 | Myosin-10 | Homo sapiens | 2 | Detail |
P62136 |
PPP1CA | Serine/threonine-protein phosphatase PP1-alpha catalytic sub | Homo sapiens | 2 | Detail |
P60763 |
RAC3 | Ras-related C3 botulinum toxin substrate 3 | Homo sapiens | 2 | Detail |
P02748 |
C9 | Complement component C9 | Homo sapiens | 2 | Detail |
O43707 |
ACTN4 | Alpha-actinin-4 | Homo sapiens | 2 | Detail |
P46940 |
IQGAP1 | Ras GTPase-activating-like protein IQGAP1 | Homo sapiens | 2 | Detail |
O15145 |
ARPC3 | Actin-related protein 2/3 complex subunit 3 | Homo sapiens | 1 | Detail |
O15143 |
ARPC1B | Actin-related protein 2/3 complex subunit 1B | Homo sapiens | 1 | Detail |
O15144 |
ARPC2 | Actin-related protein 2/3 complex subunit 2 | Homo sapiens | 1 | Detail |
P23528 |
CFL1 | Cofilin-1 | Homo sapiens | 1 | Detail |
P46109 |
CRKL | Crk-like protein | Homo sapiens | 1 | Detail |
O60610 |
DIAPH1 | Protein diaphanous homolog 1 | Homo sapiens | 1 | Detail |
Q7L576 |
CYFIP1 | Cytoplasmic FMR1-interacting protein 1 | Homo sapiens | 1 | Detail |
P23229 |
ITGA6 | Integrin alpha-6 | Homo sapiens | 1 | Detail |
P26038 |
MSN | Moesin | Homo sapiens | 1 | Detail |
P04085 |
PDGFA | Platelet-derived growth factor subunit A | Homo sapiens | 1 | Detail |
P35241 |
RDX | Radixin | Homo sapiens | 1 | Detail |
P15498 |
VAV1 | Proto-oncogene vav | Homo sapiens | 1 | Detail |
P18206 |
VCL | Vinculin | Homo sapiens | 1 | Detail |
P15311 |
EZR | Ezrin | Homo sapiens | 1 | Detail |
Q7Z406 |
MYH14 | Myosin-14 | Homo sapiens | 1 | Detail |
Q9BPX5 |
ARPC5L | Actin-related protein 2/3 complex subunit 5-like protein | Homo sapiens | 1 | Detail |
P12814 |
ACTN1 | Alpha-actinin-1 | Homo sapiens | 1 | Detail |