Serotonergic synapse
hsa04726 81 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
P18505 |
GABRB1 | Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens | 5316 | Detail |
P28223 |
HTR2A | 5-hydroxytryptamine receptor 2A | Homo sapiens | 4720 | Detail |
P31645 |
SLC6A4 | Sodium-dependent serotonin transporter | Homo sapiens | 3668 | Detail |
P08908 |
HTR1A | 5-hydroxytryptamine receptor 1A | Homo sapiens | 3572 | Detail |
P15056 |
BRAF | Serine/threonine-protein kinase B-raf | Homo sapiens | 2643 | Detail |
P28335 |
HTR2C | 5-hydroxytryptamine receptor 2C | Homo sapiens | 2557 | Detail |
P04049 |
RAF1 | RAF proto-oncogene serine/threonine-protein kinase | Homo sapiens | 2133 | Detail |
P01116 |
KRAS | GTPase KRas | Homo sapiens | 1811 | Detail |
P34969 |
HTR7 | 5-hydroxytryptamine receptor 7 | Homo sapiens | 1724 | Detail |
P41595 |
HTR2B | 5-hydroxytryptamine receptor 2B | Homo sapiens | 1466 | Detail |
P28472 |
GABRB3 | Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens | 1198 | Detail |
P50406 |
HTR6 | 5-hydroxytryptamine receptor 6 | Homo sapiens | 1058 | Detail |
P28221 |
HTR1D | 5-hydroxytryptamine receptor 1D | Homo sapiens | 1019 | Detail |
P28222 |
HTR1B | 5-hydroxytryptamine receptor 1B | Homo sapiens | 999 | Detail |
P01111 |
NRAS | GTPase NRas | Homo sapiens | 923 | Detail |
P28482 |
MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens | 906 | Detail |
P17252 |
PRKCA | Protein kinase C alpha type | Homo sapiens | 679 | Detail |
P27338 |
MAOB | Amine oxidase [flavin-containing] B | Homo sapiens | 657 | Detail |
P10635 |
CYP2D6 | Cytochrome P450 2D6 | Homo sapiens | 601 | Detail |
Q02750 |
MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens | 543 | Detail |
P21397 |
MAOA | Amine oxidase [flavin-containing] A | Homo sapiens | 522 | Detail |
P05771 |
PRKCB | Protein kinase C beta type | Homo sapiens | 457 | Detail |
P17612 |
PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | Homo sapiens | 453 | Detail |
P47870 |
GABRB2 | Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens | 445 | Detail |
P42574 |
CASP3 | Caspase-3 | Homo sapiens | 444 | Detail |
P35354 |
PTGS2 | Prostaglandin G/H synthase 2 | Homo sapiens | 424 | Detail |
P11712 |
CYP2C9 | Cytochrome P450 2C9 | Homo sapiens | 408 | Detail |
P46098 |
HTR3A | 5-hydroxytryptamine receptor 3A | Homo sapiens | 382 | Detail |
P23219 |
PTGS1 | Prostaglandin G/H synthase 1 | Homo sapiens | 365 | Detail |
P05067 |
APP | Amyloid-beta precursor protein | Homo sapiens | 345 | Detail |
P09917 |
ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens | 323 | Detail |
P05129 |
PRKCG | Protein kinase C gamma type | Homo sapiens | 311 | Detail |
P27361 |
MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens | 234 | Detail |
P33261 |
CYP2C19 | Cytochrome P450 2C19 | Homo sapiens | 197 | Detail |
O95264 |
HTR3B | 5-hydroxytryptamine receptor 3B | Homo sapiens | 185 | Detail |
Q8WXA8 |
HTR3C | 5-hydroxytryptamine receptor 3C | Homo sapiens | 183 | Detail |
A5X5Y0 |
HTR3E | 5-hydroxytryptamine receptor 3E | Homo sapiens | 183 | Detail |
Q70Z44 |
HTR3D | 5-hydroxytryptamine receptor 3D | Homo sapiens | 182 | Detail |
Q13936 |
CACNA1C | Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens | 147 | Detail |
P48549 |
KCNJ3 | G protein-activated inward rectifier potassium channel 1 | Homo sapiens | 143 | Detail |
P48544 |
KCNJ5 | G protein-activated inward rectifier potassium channel 4 | Homo sapiens | 140 | Detail |
P22694 |
PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Homo sapiens | 121 | Detail |
P47898 |
HTR5A | 5-hydroxytryptamine receptor 5A | Homo sapiens | 120 | Detail |
Q01668 |
CACNA1D | Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens | 117 | Detail |
O60840 |
CACNA1F | Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens | 117 | Detail |
Q13698 |
CACNA1S | Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens | 117 | Detail |
P22612 |
PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | Homo sapiens | 111 | Detail |
Q00975 |
CACNA1B | Voltage-dependent N-type calcium channel subunit alpha-1B | Homo sapiens | 96 | Detail |
P30939 |
HTR1F | 5-hydroxytryptamine receptor 1F | Homo sapiens | 95 | Detail |
Q13639 |
HTR4 | 5-hydroxytryptamine receptor 4 | Homo sapiens | 85 | Detail |
Q8IWU9 |
TPH2 | Tryptophan 5-hydroxylase 2 | Homo sapiens | 77 | Detail |
P17752 |
TPH1 | Tryptophan 5-hydroxylase 1 | Homo sapiens | 77 | Detail |
P10632 |
CYP2C8 | Cytochrome P450 2C8 | Homo sapiens | 62 | Detail |
P28566 |
HTR1E | 5-hydroxytryptamine receptor 1E | Homo sapiens | 60 | Detail |
O00555 |
CACNA1A | Voltage-dependent P/Q-type calcium channel subunit alpha-1A | Homo sapiens | 45 | Detail |
P10398 |
ARAF | Serine/threonine-protein kinase A-Raf | Homo sapiens | 37 | Detail |
O95622 |
ADCY5 | Adenylate cyclase type 5 | Homo sapiens | 23 | Detail |
P48051 |
KCNJ6 | G protein-activated inward rectifier potassium channel 2 | Homo sapiens | 15 | Detail |
P16050 |
ALOX15 | Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens | 14 | Detail |
P01112 |
HRAS | GTPase HRas | Homo sapiens | 14 | Detail |
Q9H2S1 |
KCNN2 | Small conductance calcium-activated potassium channel protei | Homo sapiens | 11 | Detail |
P18054 |
ALOX12 | Polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens | 10 | Detail |
P47712 |
PLA2G4A | Cytosolic phospholipase A2 | Homo sapiens | 10 | Detail |
P51589 |
CYP2J2 | Cytochrome P450 2J2 | Homo sapiens | 8 | Detail |
Q05940 |
SLC18A2 | Synaptic vesicular amine transporter | Homo sapiens | 6 | Detail |
P48995 |
TRPC1 | Short transient receptor potential channel 1 | Homo sapiens | 6 | Detail |
P28562 |
DUSP1 | Dual specificity protein phosphatase 1 | Homo sapiens | 4 | Detail |
Q14643 |
ITPR1 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 | Homo sapiens | 4 | Detail |
Q14573 |
ITPR3 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 | Homo sapiens | 4 | Detail |
P0C869 |
PLA2G4B | Cytosolic phospholipase A2 beta | Homo sapiens | 3 | Detail |
P33260 |
CYP2C18 | Cytochrome P450 2C18 | Homo sapiens | 3 | Detail |
P04899 |
GNAI2 | Guanine nucleotide-binding protein G(i) subunit alpha-2 | Homo sapiens | 3 | Detail |
Q14571 |
ITPR2 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 | Homo sapiens | 3 | Detail |
P08754 |
GNAI3 | Guanine nucleotide-binding protein G(i) subunit alpha-3 | Homo sapiens | 2 | Detail |
P50148 |
GNAQ | Guanine nucleotide-binding protein G(q) subunit alpha | Homo sapiens | 2 | Detail |
P62873 |
GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit be | Homo sapiens | 2 | Detail |
P59768 |
GNG2 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit ga | Homo sapiens | 2 | Detail |
Q9UP65 |
PLA2G4C | Cytosolic phospholipase A2 gamma | Homo sapiens | 2 | Detail |
P20711 |
DDC | Aromatic-L-amino-acid decarboxylase | Homo sapiens | 1 | Detail |
O15296 |
ALOX15B | Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens | 1 | Detail |
Q9NZV8 |
KCND2 | A-type voltage-gated potassium channel KCND2 | Homo sapiens | 1 | Detail |