TNF signaling pathway
hsa04668 70 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
P42336 |
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 5616 | Detail |
O00329 |
PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 3772 | Detail |
P27986 |
PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | Homo sapiens | 2553 | Detail |
P42338 |
PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 1951 | Detail |
P14780 |
MMP9 | Matrix metalloproteinase-9 | Homo sapiens | 1941 | Detail |
Q16539 |
MAPK14 | Mitogen-activated protein kinase 14 | Homo sapiens | 1754 | Detail |
P31749 |
AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens | 1633 | Detail |
P08254 |
MMP3 | Stromelysin-1 | Homo sapiens | 1292 | Detail |
P28482 |
MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens | 906 | Detail |
P98170 |
XIAP | E3 ubiquitin-protein ligase XIAP | Homo sapiens | 897 | Detail |
P31751 |
AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens | 896 | Detail |
Q13490 |
BIRC2 | Baculoviral IAP repeat-containing protein 2 | Homo sapiens | 876 | Detail |
P78536 |
ADAM17 | Disintegrin and metalloproteinase domain-containing protein | Homo sapiens | 785 | Detail |
P45983 |
MAPK8 | Mitogen-activated protein kinase 8 | Homo sapiens | 748 | Detail |
P45984 |
MAPK9 | Mitogen-activated protein kinase 9 | Homo sapiens | 676 | Detail |
P53779 |
MAPK10 | Mitogen-activated protein kinase 10 | Homo sapiens | 625 | Detail |
P53778 |
MAPK12 | Mitogen-activated protein kinase 12 | Homo sapiens | 606 | Detail |
Q15759 |
MAPK11 | Mitogen-activated protein kinase 11 | Homo sapiens | 594 | Detail |
Q02750 |
MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens | 543 | Detail |
O15264 |
MAPK13 | Mitogen-activated protein kinase 13 | Homo sapiens | 533 | Detail |
Q13489 |
BIRC3 | Baculoviral IAP repeat-containing protein 3 | Homo sapiens | 532 | Detail |
O00459 |
PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | Homo sapiens | 485 | Detail |
P05362 |
ICAM1 | Intercellular adhesion molecule 1 | Homo sapiens | 462 | Detail |
P42574 |
CASP3 | Caspase-3 | Homo sapiens | 444 | Detail |
P35354 |
PTGS2 | Prostaglandin G/H synthase 2 | Homo sapiens | 424 | Detail |
O14920 |
IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | Homo sapiens | 411 | Detail |
P50281 |
MMP14 | Matrix metalloproteinase-14 | Homo sapiens | 409 | Detail |
Q9Y243 |
AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens | 321 | Detail |
Q13546 |
RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | Homo sapiens | 315 | Detail |
P55210 |
CASP7 | Caspase-7 | Homo sapiens | 306 | Detail |
Q92569 |
PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | Homo sapiens | 289 | Detail |
Q8NB16 |
MLKL | Mixed lineage kinase domain-like protein | Homo sapiens | 254 | Detail |
P27361 |
MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens | 234 | Detail |
Q99558 |
MAP3K14 | Mitogen-activated protein kinase kinase kinase 14 | Homo sapiens | 224 | Detail |
Q14790 |
CASP8 | Caspase-8 | Homo sapiens | 219 | Detail |
P02778 |
CXCL10 | C-X-C motif chemokine 10 | Homo sapiens | 197 | Detail |
O43318 |
MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | Homo sapiens | 178 | Detail |
O15111 |
CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | Homo sapiens | 170 | Detail |
O75582 |
RPS6KA5 | Ribosomal protein S6 kinase alpha-5 | Homo sapiens | 157 | Detail |
P01584 |
IL1B | Interleukin-1 beta | Homo sapiens | 148 | Detail |
P01375 |
TNF | Tumor necrosis factor | Homo sapiens | 144 | Detail |
P19838 |
NFKB1 | Nuclear factor NF-kappa-B p105 subunit | Homo sapiens | 140 | Detail |
Q04206 |
RELA | Transcription factor p65 | Homo sapiens | 134 | Detail |
P16581 |
SELE | E-selectin | Homo sapiens | 99 | Detail |
Q15750 |
TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | Homo sapiens | 97 | Detail |
Q99683 |
MAP3K5 | Mitogen-activated protein kinase kinase kinase 5 | Homo sapiens | 81 | Detail |
P05412 |
JUN | Transcription factor Jun | Homo sapiens | 69 | Detail |
Q9Y572 |
RIPK3 | Receptor-interacting serine/threonine-protein kinase 3 | Homo sapiens | 67 | Detail |
P13500 |
CCL2 | C-C motif chemokine 2 | Homo sapiens | 65 | Detail |
P19320 |
VCAM1 | Vascular cell adhesion protein 1 | Homo sapiens | 64 | Detail |
Q9HC29 |
NOD2 | Nucleotide-binding oligomerization domain-containing protein | Homo sapiens | 60 | Detail |
O75676 |
RPS6KA4 | Ribosomal protein S6 kinase alpha-4 | Homo sapiens | 60 | Detail |
P45985 |
MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | Homo sapiens | 31 | Detail |
P01100 |
FOS | Protein c-Fos | Homo sapiens | 25 | Detail |
P05231 |
IL6 | Interleukin-6 | Homo sapiens | 17 | Detail |
P52564 |
MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | Homo sapiens | 17 | Detail |
P41279 |
MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | Homo sapiens | 15 | Detail |
O14733 |
MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 | Homo sapiens | 15 | Detail |
Q9Y6K9 |
IKBKG | NF-kappa-B essential modulator | Homo sapiens | 13 | Detail |
P46734 |
MAP2K3 | Dual specificity mitogen-activated protein kinase kinase 3 | Homo sapiens | 12 | Detail |
P13501 |
CCL5 | C-C motif chemokine 5 | Homo sapiens | 12 | Detail |
Q92851 |
CASP10 | Caspase-10 | Homo sapiens | 10 | Detail |
P40933 |
IL15 | Interleukin-15 | Homo sapiens | 7 | Detail |
P04141 |
CSF2 | Granulocyte-macrophage colony-stimulating factor | Homo sapiens | 4 | Detail |
P19438 |
TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A | Homo sapiens | 2 | Detail |
Q5VWQ8 |
DAB2IP | Disabled homolog 2-interacting protein | Homo sapiens | 1 | Detail |
Q96HS1 |
PGAM5 | Serine/threonine-protein phosphatase PGAM5, mitochondrial | Homo sapiens | 1 | Detail |
P25963 |
NFKBIA | NF-kappa-B inhibitor alpha | Homo sapiens | 1 | Detail |
P20333 |
TNFRSF1B | Tumor necrosis factor receptor superfamily member 1B | Homo sapiens | 1 | Detail |
Q12933 |
TRAF2 | TNF receptor-associated factor 2 | Homo sapiens | 1 | Detail |