JAK-STAT signaling pathway

hsa04630 53 targets in this pathway

UniProt AC Gene Protein Name Organism Multi-Target Molecules
O60674 JAK2 Tyrosine-protein kinase JAK2 Homo sapiens 10545 Detail
P23458 JAK1 Tyrosine-protein kinase JAK1 Homo sapiens 8920 Detail
P42336 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub Homo sapiens 5616 Detail
P52333 JAK3 Tyrosine-protein kinase JAK3 Homo sapiens 5161 Detail
P29597 TYK2 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens 3837 Detail
O00329 PIK3CD Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub Homo sapiens 3772 Detail
P00533 EGFR Epidermal growth factor receptor Homo sapiens 3433 Detail
P11309 PIM1 Serine/threonine-protein kinase pim-1 Homo sapiens 2647 Detail
P27986 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha Homo sapiens 2553 Detail
P42345 MTOR Serine/threonine-protein kinase mTOR Homo sapiens 2517 Detail
P04049 RAF1 RAF proto-oncogene serine/threonine-protein kinase Homo sapiens 2133 Detail
Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Homo sapiens 2063 Detail
P42338 PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub Homo sapiens 1951 Detail
P24385 CCND1 G1/S-specific cyclin-D1 Homo sapiens 1643 Detail
P31749 AKT1 RAC-alpha serine/threonine-protein kinase Homo sapiens 1633 Detail
P09619 PDGFRB Platelet-derived growth factor receptor beta Homo sapiens 1527 Detail
P10415 BCL2 Apoptosis regulator Bcl-2 Homo sapiens 1065 Detail
Q07817 BCL2L1 Bcl-2-like protein 1 Homo sapiens 990 Detail
P31751 AKT2 RAC-beta serine/threonine-protein kinase Homo sapiens 896 Detail
P16234 PDGFRA Platelet-derived growth factor receptor alpha Homo sapiens 860 Detail
Q07889 SOS1 Son of sevenless homolog 1 Homo sapiens 766 Detail
P30281 CCND3 G1/S-specific cyclin-D3 Homo sapiens 656 Detail
O00459 PIK3R2 Phosphatidylinositol 3-kinase regulatory subunit beta Homo sapiens 485 Detail
Q92793 CREBBP CREB-binding protein Homo sapiens 423 Detail
Q9Y243 AKT3 RAC-gamma serine/threonine-protein kinase Homo sapiens 321 Detail
Q09472 EP300 Histone acetyltransferase p300 Homo sapiens 320 Detail
Q92569 PIK3R3 Phosphatidylinositol 3-kinase regulatory subunit gamma Homo sapiens 289 Detail
Q06124 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 Homo sapiens 214 Detail
P17706 PTPN2 Tyrosine-protein phosphatase non-receptor type 2 Homo sapiens 199 Detail
P15260 IFNGR1 Interferon gamma receptor 1 Homo sapiens 150 Detail
P05112 IL4 Interleukin-4 Homo sapiens 146 Detail
P35225 IL13 Interleukin-13 Homo sapiens 90 Detail
P30279 CCND2 G1/S-specific cyclin-D2 Homo sapiens 71 Detail
P40763 STAT3 Signal transducer and activator of transcription 3 Homo sapiens 49 Detail
P60568 IL2 Interleukin-2 Homo sapiens 29 Detail
P01106 MYC Myc proto-oncogene protein Homo sapiens 19 Detail
P05231 IL6 Interleukin-6 Homo sapiens 17 Detail
P01127 PDGFB Platelet-derived growth factor subunit B Homo sapiens 16 Detail
P01112 HRAS GTPase HRas Homo sapiens 14 Detail
P29350 PTPN6 Tyrosine-protein phosphatase non-receptor type 6 Homo sapiens 12 Detail
P42229 STAT5A Signal transducer and activator of transcription 5A Homo sapiens 11 Detail
P42226 STAT6 Signal transducer and activator of transcription 6 Homo sapiens 10 Detail
Q06278 AOX1 Aldehyde oxidase Homo sapiens 7 Detail
P40933 IL15 Interleukin-15 Homo sapiens 7 Detail
P51692 STAT5B Signal transducer and activator of transcription 5B Homo sapiens 5 Detail
P04141 CSF2 Granulocyte-macrophage colony-stimulating factor Homo sapiens 4 Detail
P62993 GRB2 Growth factor receptor-bound protein 2 Homo sapiens 4 Detail
P42224 STAT1 Signal transducer and activator of transcription 1-alpha/bet Homo sapiens 4 Detail
Q13261 IL15RA Interleukin-15 receptor subunit alpha Homo sapiens 3 Detail
P38936 CDKN1A Cyclin-dependent kinase inhibitor 1 Homo sapiens 1 Detail
P04085 PDGFA Platelet-derived growth factor subunit A Homo sapiens 1 Detail
Q9HBE4 IL21 Interleukin-21 Homo sapiens 1 Detail
Q14765 STAT4 Signal transducer and activator of transcription 4 Homo sapiens 1 Detail