Cytosolic DNA-sensing pathway

hsa04623 33 targets in this pathway

UniProt AC Gene Protein Name Organism Multi-Target Molecules
Q9UHD2 TBK1 Serine/threonine-protein kinase TBK1 Homo sapiens 639 Detail
Q14164 IKBKE Inhibitor of nuclear factor kappa-B kinase subunit epsilon Homo sapiens 596 Detail
P42574 CASP3 Caspase-3 Homo sapiens 444 Detail
O14920 IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta Homo sapiens 411 Detail
Q13546 RIPK1 Receptor-interacting serine/threonine-protein kinase 1 Homo sapiens 315 Detail
P55210 CASP7 Caspase-7 Homo sapiens 306 Detail
Q8NB16 MLKL Mixed lineage kinase domain-like protein Homo sapiens 254 Detail
Q14790 CASP8 Caspase-8 Homo sapiens 219 Detail
P02778 CXCL10 C-X-C motif chemokine 10 Homo sapiens 197 Detail
P29466 CASP1 Caspase-1 Homo sapiens 173 Detail
O15111 CHUK Inhibitor of nuclear factor kappa-B kinase subunit alpha Homo sapiens 170 Detail
P01584 IL1B Interleukin-1 beta Homo sapiens 148 Detail
P19838 NFKB1 Nuclear factor NF-kappa-B p105 subunit Homo sapiens 140 Detail
Q04206 RELA Transcription factor p65 Homo sapiens 134 Detail
Q9Y572 RIPK3 Receptor-interacting serine/threonine-protein kinase 3 Homo sapiens 67 Detail
Q9NSU2 TREX1 Three-prime repair exonuclease 1 Homo sapiens 22 Detail
P05231 IL6 Interleukin-6 Homo sapiens 17 Detail
Q96P20 NLRP3 NACHT, LRR and PYD domains-containing protein 3 Homo sapiens 16 Detail
Q9Y6K9 IKBKG NF-kappa-B essential modulator Homo sapiens 13 Detail
P13501 CCL5 C-C motif chemokine 5 Homo sapiens 12 Detail
P55265 ADAR Double-stranded RNA-specific adenosine deaminase Homo sapiens 2 Detail
Q8N884 CGAS Cyclic GMP-AMP synthase Homo sapiens 2 Detail
P57764 GSDMD Gasdermin-D Homo sapiens 2 Detail
Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 Homo sapiens 1 Detail
Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Homo sapiens 1 Detail
Q86WV6 STING1 Stimulator of interferon genes protein Homo sapiens 1 Detail
P25963 NFKBIA NF-kappa-B inhibitor alpha Homo sapiens 1 Detail
Q15365 PCBP1 Poly(rC)-binding protein 1 Homo sapiens 1 Detail
Q9UJV9 DDX41 Probable ATP-dependent RNA helicase DDX41 Homo sapiens 1 Detail
P19388 POLR2E DNA-directed RNA polymerases I, II, and III subunit RPABC1 Homo sapiens 1 Detail
P52434 POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 Homo sapiens 1 Detail
Q7Z434 MAVS Mitochondrial antiviral-signaling protein Homo sapiens 1 Detail
O15160 POLR1C DNA-directed RNA polymerases I and III subunit RPAC1 Homo sapiens 1 Detail