Toll-like receptor signaling pathway
hsa04620 64 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
P23458 |
JAK1 | Tyrosine-protein kinase JAK1 | Homo sapiens | 8920 | Detail |
P42336 |
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 5616 | Detail |
P29597 |
TYK2 | Non-receptor tyrosine-protein kinase TYK2 | Homo sapiens | 3837 | Detail |
O00329 |
PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 3772 | Detail |
Q9NYK1 |
TLR7 | Toll-like receptor 7 | Homo sapiens | 3666 | Detail |
Q9NR97 |
TLR8 | Toll-like receptor 8 | Homo sapiens | 3645 | Detail |
P27986 |
PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | Homo sapiens | 2553 | Detail |
P42338 |
PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 1951 | Detail |
Q16539 |
MAPK14 | Mitogen-activated protein kinase 14 | Homo sapiens | 1754 | Detail |
P31749 |
AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens | 1633 | Detail |
Q9NR96 |
TLR9 | Toll-like receptor 9 | Homo sapiens | 1027 | Detail |
P28482 |
MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens | 906 | Detail |
P31751 |
AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens | 896 | Detail |
P43235 |
CTSK | Cathepsin K | Homo sapiens | 835 | Detail |
P45983 |
MAPK8 | Mitogen-activated protein kinase 8 | Homo sapiens | 748 | Detail |
P45984 |
MAPK9 | Mitogen-activated protein kinase 9 | Homo sapiens | 676 | Detail |
Q9UHD2 |
TBK1 | Serine/threonine-protein kinase TBK1 | Homo sapiens | 639 | Detail |
P53779 |
MAPK10 | Mitogen-activated protein kinase 10 | Homo sapiens | 625 | Detail |
P53778 |
MAPK12 | Mitogen-activated protein kinase 12 | Homo sapiens | 606 | Detail |
Q14164 |
IKBKE | Inhibitor of nuclear factor kappa-B kinase subunit epsilon | Homo sapiens | 596 | Detail |
Q15759 |
MAPK11 | Mitogen-activated protein kinase 11 | Homo sapiens | 594 | Detail |
Q02750 |
MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens | 543 | Detail |
O15264 |
MAPK13 | Mitogen-activated protein kinase 13 | Homo sapiens | 533 | Detail |
O00459 |
PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | Homo sapiens | 485 | Detail |
Q9NWZ3 |
IRAK4 | Interleukin-1 receptor-associated kinase 4 | Homo sapiens | 431 | Detail |
O14920 |
IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | Homo sapiens | 411 | Detail |
Q9Y243 |
AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens | 321 | Detail |
Q13546 |
RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | Homo sapiens | 315 | Detail |
P51617 |
IRAK1 | Interleukin-1 receptor-associated kinase 1 | Homo sapiens | 312 | Detail |
Q92569 |
PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | Homo sapiens | 289 | Detail |
P27361 |
MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens | 234 | Detail |
Q14790 |
CASP8 | Caspase-8 | Homo sapiens | 219 | Detail |
P02778 |
CXCL10 | C-X-C motif chemokine 10 | Homo sapiens | 197 | Detail |
O43318 |
MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | Homo sapiens | 178 | Detail |
O15111 |
CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | Homo sapiens | 170 | Detail |
P01584 |
IL1B | Interleukin-1 beta | Homo sapiens | 148 | Detail |
P36507 |
MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | Homo sapiens | 146 | Detail |
P01375 |
TNF | Tumor necrosis factor | Homo sapiens | 144 | Detail |
P19838 |
NFKB1 | Nuclear factor NF-kappa-B p105 subunit | Homo sapiens | 140 | Detail |
Q04206 |
RELA | Transcription factor p65 | Homo sapiens | 134 | Detail |
Q15750 |
TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | Homo sapiens | 97 | Detail |
P05412 |
JUN | Transcription factor Jun | Homo sapiens | 69 | Detail |
P45985 |
MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | Homo sapiens | 31 | Detail |
P01100 |
FOS | Protein c-Fos | Homo sapiens | 25 | Detail |
P05231 |
IL6 | Interleukin-6 | Homo sapiens | 17 | Detail |
P52564 |
MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | Homo sapiens | 17 | Detail |
P41279 |
MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | Homo sapiens | 15 | Detail |
O14733 |
MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 | Homo sapiens | 15 | Detail |
O60603 |
TLR2 | Toll-like receptor 2 | Homo sapiens | 14 | Detail |
Q9Y2C9 |
TLR6 | Toll-like receptor 6 | Homo sapiens | 13 | Detail |
Q9Y6K9 |
IKBKG | NF-kappa-B essential modulator | Homo sapiens | 13 | Detail |
P46734 |
MAP2K3 | Dual specificity mitogen-activated protein kinase kinase 3 | Homo sapiens | 12 | Detail |
P13501 |
CCL5 | C-C motif chemokine 5 | Homo sapiens | 12 | Detail |
P10145 |
CXCL8 | Interleukin-8 | Homo sapiens | 9 | Detail |
O00206 |
TLR4 | Toll-like receptor 4 | Homo sapiens | 9 | Detail |
Q9Y6Y9 |
LY96 | Lymphocyte antigen 96 | Homo sapiens | 6 | Detail |
P10147 |
CCL3 | C-C motif chemokine 3 | Homo sapiens | 5 | Detail |
P42224 |
STAT1 | Signal transducer and activator of transcription 1-alpha/bet | Homo sapiens | 4 | Detail |
P25942 |
CD40 | Tumor necrosis factor receptor superfamily member 5 | Homo sapiens | 4 | Detail |
P63000 |
RAC1 | Ras-related C3 botulinum toxin substrate 1 | Homo sapiens | 3 | Detail |
P08571 |
CD14 | Monocyte differentiation antigen CD14 | Homo sapiens | 2 | Detail |
P25963 |
NFKBIA | NF-kappa-B inhibitor alpha | Homo sapiens | 1 | Detail |
Q15399 |
TLR1 | Toll-like receptor 1 | Homo sapiens | 1 | Detail |
O15455 |
TLR3 | Toll-like receptor 3 | Homo sapiens | 1 | Detail |