Osteoclast differentiation
hsa04380 73 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
P23458 |
JAK1 | Tyrosine-protein kinase JAK1 | Homo sapiens | 8920 | Detail |
P42336 |
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 5616 | Detail |
P29597 |
TYK2 | Non-receptor tyrosine-protein kinase TYK2 | Homo sapiens | 3837 | Detail |
O00329 |
PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 3772 | Detail |
P27986 |
PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | Homo sapiens | 2553 | Detail |
P05106 |
ITGB3 | Integrin beta-3 | Homo sapiens | 2474 | Detail |
P42338 |
PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 1951 | Detail |
Q16539 |
MAPK14 | Mitogen-activated protein kinase 14 | Homo sapiens | 1754 | Detail |
P31749 |
AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens | 1633 | Detail |
Q06187 |
BTK | Tyrosine-protein kinase BTK | Homo sapiens | 1619 | Detail |
P06239 |
LCK | Tyrosine-protein kinase Lck | Homo sapiens | 1537 | Detail |
P28482 |
MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens | 906 | Detail |
P07333 |
CSF1R | Macrophage colony-stimulating factor 1 receptor | Homo sapiens | 896 | Detail |
P31751 |
AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens | 896 | Detail |
P43405 |
SYK | Tyrosine-protein kinase SYK | Homo sapiens | 852 | Detail |
P43235 |
CTSK | Cathepsin K | Homo sapiens | 835 | Detail |
P45983 |
MAPK8 | Mitogen-activated protein kinase 8 | Homo sapiens | 748 | Detail |
P45984 |
MAPK9 | Mitogen-activated protein kinase 9 | Homo sapiens | 676 | Detail |
P53779 |
MAPK10 | Mitogen-activated protein kinase 10 | Homo sapiens | 625 | Detail |
P53778 |
MAPK12 | Mitogen-activated protein kinase 12 | Homo sapiens | 606 | Detail |
Q15759 |
MAPK11 | Mitogen-activated protein kinase 11 | Homo sapiens | 594 | Detail |
Q02750 |
MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens | 543 | Detail |
O15264 |
MAPK13 | Mitogen-activated protein kinase 13 | Homo sapiens | 533 | Detail |
O00459 |
PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | Homo sapiens | 485 | Detail |
P36897 |
TGFBR1 | TGF-beta receptor type-1 | Homo sapiens | 428 | Detail |
P37231 |
PPARG | Peroxisome proliferator-activated receptor gamma | Homo sapiens | 417 | Detail |
O14920 |
IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | Homo sapiens | 411 | Detail |
P06241 |
FYN | Tyrosine-protein kinase Fyn | Homo sapiens | 333 | Detail |
Q9Y243 |
AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens | 321 | Detail |
P42680 |
TEC | Tyrosine-protein kinase Tec | Homo sapiens | 309 | Detail |
Q92569 |
PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | Homo sapiens | 289 | Detail |
P27361 |
MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens | 234 | Detail |
Q99558 |
MAP3K14 | Mitogen-activated protein kinase kinase kinase 14 | Homo sapiens | 224 | Detail |
O43318 |
MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | Homo sapiens | 178 | Detail |
O15111 |
CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | Homo sapiens | 170 | Detail |
P15260 |
IFNGR1 | Interferon gamma receptor 1 | Homo sapiens | 150 | Detail |
P01584 |
IL1B | Interleukin-1 beta | Homo sapiens | 148 | Detail |
P37173 |
TGFBR2 | TGF-beta receptor type-2 | Homo sapiens | 144 | Detail |
P01375 |
TNF | Tumor necrosis factor | Homo sapiens | 144 | Detail |
P19838 |
NFKB1 | Nuclear factor NF-kappa-B p105 subunit | Homo sapiens | 140 | Detail |
P30988 |
CALCR | Calcitonin receptor | Homo sapiens | 135 | Detail |
Q04206 |
RELA | Transcription factor p65 | Homo sapiens | 134 | Detail |
Q00653 |
NFKB2 | Nuclear factor NF-kappa-B p100 subunit | Homo sapiens | 126 | Detail |
Q15750 |
TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | Homo sapiens | 97 | Detail |
P05412 |
JUN | Transcription factor Jun | Homo sapiens | 69 | Detail |
P48454 |
PPP3CC | Serine/threonine-protein phosphatase 2B catalytic subunit ga | Homo sapiens | 27 | Detail |
P01100 |
FOS | Protein c-Fos | Homo sapiens | 25 | Detail |
P52564 |
MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | Homo sapiens | 17 | Detail |
O14733 |
MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 | Homo sapiens | 15 | Detail |
Q16566 |
CAMK4 | Calcium/calmodulin-dependent protein kinase type IV | Homo sapiens | 14 | Detail |
Q9Y6K9 |
IKBKG | NF-kappa-B essential modulator | Homo sapiens | 13 | Detail |
P01137 |
TGFB1 | Transforming growth factor beta-1 proprotein | Homo sapiens | 8 | Detail |
Q13094 |
LCP2 | Lymphocyte cytosolic protein 2 | Homo sapiens | 6 | Detail |
Q9Y5S8 |
NOX1 | NADPH oxidase 1 | Homo sapiens | 5 | Detail |
P16615 |
ATP2A2 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | Homo sapiens | 5 | Detail |
P14598 |
NCF1 | Neutrophil cytosol factor 1 | Homo sapiens | 5 | Detail |
P62993 |
GRB2 | Growth factor receptor-bound protein 2 | Homo sapiens | 4 | Detail |
Q14643 |
ITPR1 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 | Homo sapiens | 4 | Detail |
Q14573 |
ITPR3 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 | Homo sapiens | 4 | Detail |
Q08209 |
PPP3CA | Protein phosphatase 3 catalytic subunit alpha | Homo sapiens | 4 | Detail |
P42224 |
STAT1 | Signal transducer and activator of transcription 1-alpha/bet | Homo sapiens | 4 | Detail |
Q14571 |
ITPR2 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 | Homo sapiens | 3 | Detail |
P63000 |
RAC1 | Ras-related C3 botulinum toxin substrate 1 | Homo sapiens | 3 | Detail |
O14983 |
ATP2A1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Homo sapiens | 2 | Detail |
Q93084 |
ATP2A3 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | Homo sapiens | 2 | Detail |
P16885 |
PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase ga | Homo sapiens | 2 | Detail |
P61812 |
TGFB2 | Transforming growth factor beta-2 proprotein | Homo sapiens | 2 | Detail |
P19438 |
TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A | Homo sapiens | 2 | Detail |
P14778 |
IL1R1 | Interleukin-1 receptor type 1 | Homo sapiens | 1 | Detail |
P25963 |
NFKBIA | NF-kappa-B inhibitor alpha | Homo sapiens | 1 | Detail |
Q12933 |
TRAF2 | TNF receptor-associated factor 2 | Homo sapiens | 1 | Detail |
O14788 |
TNFSF11 | Tumor necrosis factor ligand superfamily member 11 | Homo sapiens | 1 | Detail |
Q13501 |
SQSTM1 | Sequestosome-1 | Homo sapiens | 1 | Detail |