Adrenergic signaling in cardiomyocytes
hsa04261 87 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
P48736 |
PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 2398 | Detail |
Q16539 |
MAPK14 | Mitogen-activated protein kinase 14 | Homo sapiens | 1754 | Detail |
P35348 |
ADRA1A | Alpha-1A adrenergic receptor | Homo sapiens | 1709 | Detail |
P31749 |
AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens | 1633 | Detail |
P35368 |
ADRA1B | Alpha-1B adrenergic receptor | Homo sapiens | 1393 | Detail |
P25100 |
ADRA1D | Alpha-1D adrenergic receptor | Homo sapiens | 1327 | Detail |
P10415 |
BCL2 | Apoptosis regulator Bcl-2 | Homo sapiens | 1065 | Detail |
P28482 |
MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens | 906 | Detail |
P31751 |
AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens | 896 | Detail |
P07550 |
ADRB2 | Beta-2 adrenergic receptor | Homo sapiens | 697 | Detail |
P30556 |
AGTR1 | Type-1 angiotensin II receptor | Homo sapiens | 696 | Detail |
Q14524 |
SCN5A | Sodium channel protein type 5 subunit alpha | Homo sapiens | 683 | Detail |
P17252 |
PRKCA | Protein kinase C alpha type | Homo sapiens | 679 | Detail |
P50052 |
AGTR2 | Type-2 angiotensin II receptor | Homo sapiens | 633 | Detail |
P53778 |
MAPK12 | Mitogen-activated protein kinase 12 | Homo sapiens | 606 | Detail |
Q15759 |
MAPK11 | Mitogen-activated protein kinase 11 | Homo sapiens | 594 | Detail |
P08588 |
ADRB1 | Beta-1 adrenergic receptor | Homo sapiens | 541 | Detail |
O15264 |
MAPK13 | Mitogen-activated protein kinase 13 | Homo sapiens | 533 | Detail |
P17612 |
PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | Homo sapiens | 453 | Detail |
Q9Y243 |
AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens | 321 | Detail |
Q8WYR1 |
PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | Homo sapiens | 297 | Detail |
P27361 |
MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens | 234 | Detail |
P54289 |
CACNA2D1 | Voltage-dependent calcium channel subunit alpha-2/delta-1 | Homo sapiens | 234 | Detail |
O75582 |
RPS6KA5 | Ribosomal protein S6 kinase alpha-5 | Homo sapiens | 157 | Detail |
Q13557 |
CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 150 | Detail |
Q13936 |
CACNA1C | Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens | 147 | Detail |
P05023 |
ATP1A1 | Sodium/potassium-transporting ATPase subunit alpha-1 | Homo sapiens | 135 | Detail |
P50993 |
ATP1A2 | Sodium/potassium-transporting ATPase subunit alpha-2 | Homo sapiens | 134 | Detail |
Q13555 |
CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 123 | Detail |
P05026 |
ATP1B1 | Sodium/potassium-transporting ATPase subunit beta-1 | Homo sapiens | 122 | Detail |
P22694 |
PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Homo sapiens | 121 | Detail |
P54709 |
ATP1B3 | Sodium/potassium-transporting ATPase subunit beta-3 | Homo sapiens | 120 | Detail |
P14415 |
ATP1B2 | Sodium/potassium-transporting ATPase subunit beta-2 | Homo sapiens | 119 | Detail |
Q01668 |
CACNA1D | Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens | 117 | Detail |
O60840 |
CACNA1F | Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens | 117 | Detail |
Q13698 |
CACNA1S | Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens | 117 | Detail |
P22612 |
PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | Homo sapiens | 111 | Detail |
P13637 |
ATP1A3 | Sodium/potassium-transporting ATPase subunit alpha-3 | Homo sapiens | 100 | Detail |
Q13733 |
ATP1A4 | Sodium/potassium-transporting ATPase subunit alpha-4 | Homo sapiens | 100 | Detail |
P54710 |
FXYD2 | Sodium/potassium-transporting ATPase subunit gamma | Homo sapiens | 100 | Detail |
Q02641 |
CACNB1 | Voltage-dependent L-type calcium channel subunit beta-1 | Homo sapiens | 85 | Detail |
Q9UQM7 |
CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 75 | Detail |
Q13554 |
CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 68 | Detail |
Q9NY47 |
CACNA2D2 | Voltage-dependent calcium channel subunit alpha-2/delta-2 | Homo sapiens | 63 | Detail |
Q8WXS5 |
CACNG8 | Voltage-dependent calcium channel gamma-8 subunit | Homo sapiens | 62 | Detail |
Q07699 |
SCN1B | Sodium channel regulatory subunit beta-1 | Homo sapiens | 61 | Detail |
Q9Y698 |
CACNG2 | Voltage-dependent calcium channel gamma-2 subunit | Homo sapiens | 59 | Detail |
P54284 |
CACNB3 | Voltage-dependent L-type calcium channel subunit beta-3 | Homo sapiens | 49 | Detail |
O95069 |
KCNK2 | Potassium channel subfamily K member 2 | Homo sapiens | 48 | Detail |
Q08289 |
CACNB2 | Voltage-dependent L-type calcium channel subunit beta-2 | Homo sapiens | 45 | Detail |
Q06432 |
CACNG1 | Voltage-dependent calcium channel gamma-1 subunit | Homo sapiens | 45 | Detail |
O60359 |
CACNG3 | Voltage-dependent calcium channel gamma-3 subunit | Homo sapiens | 44 | Detail |
Q9UF02 |
CACNG5 | Voltage-dependent calcium channel gamma-5 subunit | Homo sapiens | 44 | Detail |
Q9UBN1 |
CACNG4 | Voltage-dependent calcium channel gamma-4 subunit | Homo sapiens | 44 | Detail |
Q8IZS8 |
CACNA2D3 | Voltage-dependent calcium channel subunit alpha-2/delta-3 | Homo sapiens | 44 | Detail |
P62955 |
CACNG7 | Voltage-dependent calcium channel gamma-7 subunit | Homo sapiens | 44 | Detail |
Q9BXT2 |
CACNG6 | Voltage-dependent calcium channel gamma-6 subunit | Homo sapiens | 44 | Detail |
O00305 |
CACNB4 | Voltage-dependent L-type calcium channel subunit beta-4 | Homo sapiens | 44 | Detail |
Q7Z3S7 |
CACNA2D4 | Voltage-dependent calcium channel subunit alpha-2/delta-4 | Homo sapiens | 44 | Detail |
Q01118 |
SCN7A | Sodium channel protein type 7 subunit alpha | Homo sapiens | 41 | Detail |
Q08828 |
ADCY1 | Adenylate cyclase type 1 | Homo sapiens | 30 | Detail |
P40145 |
ADCY8 | Adenylate cyclase type 8 | Homo sapiens | 27 | Detail |
O95622 |
ADCY5 | Adenylate cyclase type 5 | Homo sapiens | 23 | Detail |
Q08462 |
ADCY2 | Adenylate cyclase type 2 | Homo sapiens | 21 | Detail |
O60266 |
ADCY3 | Adenylate cyclase type 3 | Homo sapiens | 21 | Detail |
O43306 |
ADCY6 | Adenylate cyclase type 6 | Homo sapiens | 21 | Detail |
P51828 |
ADCY7 | Adenylate cyclase type 7 | Homo sapiens | 21 | Detail |
O60503 |
ADCY9 | Adenylate cyclase type 9 | Homo sapiens | 21 | Detail |
Q8NFM4 |
ADCY4 | Adenylate cyclase type 4 | Homo sapiens | 21 | Detail |
P51787 |
KCNQ1 | Potassium voltage-gated channel subfamily KQT member 1 | Homo sapiens | 12 | Detail |
P15382 |
KCNE1 | Potassium voltage-gated channel subfamily E member 1 | Homo sapiens | 11 | Detail |
P19634 |
SLC9A1 | Sodium/hydrogen exchanger 1 | Homo sapiens | 10 | Detail |
Q13522 |
PPP1R1A | Protein phosphatase 1 regulatory subunit 1A | Homo sapiens | 8 | Detail |
P0DP23 |
CALM1 | Calmodulin-1 | Homo sapiens | 8 | Detail |
P16615 |
ATP2A2 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | Homo sapiens | 5 | Detail |
P36873 |
PPP1CC | Serine/threonine-protein phosphatase PP1-gamma catalytic sub | Homo sapiens | 5 | Detail |
P67775 |
PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit al | Homo sapiens | 5 | Detail |
Q15172 |
PPP2R5A | Serine/threonine-protein phosphatase 2A 56 kDa regulatory su | Homo sapiens | 4 | Detail |
P04899 |
GNAI2 | Guanine nucleotide-binding protein G(i) subunit alpha-2 | Homo sapiens | 3 | Detail |
P08754 |
GNAI3 | Guanine nucleotide-binding protein G(i) subunit alpha-3 | Homo sapiens | 2 | Detail |
P50148 |
GNAQ | Guanine nucleotide-binding protein G(q) subunit alpha | Homo sapiens | 2 | Detail |
O14983 |
ATP2A1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Homo sapiens | 2 | Detail |
Q93084 |
ATP2A3 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | Homo sapiens | 2 | Detail |
P62136 |
PPP1CA | Serine/threonine-protein phosphatase PP1-alpha catalytic sub | Homo sapiens | 2 | Detail |
P63151 |
PPP2R2A | Serine/threonine-protein phosphatase 2A 55 kDa regulatory su | Homo sapiens | 2 | Detail |
P12829 |
MYL4 | Myosin light chain 4 | Homo sapiens | 1 | Detail |
P01019 |
AGT | Angiotensinogen | Homo sapiens | 0 | Detail |