Cellular senescence
hsa04218 90 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
P42336 |
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 5616 | Detail |
P24941 |
CDK2 | Cyclin-dependent kinase 2 | Homo sapiens | 5432 | Detail |
O00329 |
PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 3772 | Detail |
P11802 |
CDK4 | Cyclin-dependent kinase 4 | Homo sapiens | 2896 | Detail |
P27986 |
PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | Homo sapiens | 2553 | Detail |
P42345 |
MTOR | Serine/threonine-protein kinase mTOR | Homo sapiens | 2517 | Detail |
P24864 |
CCNE1 | G1/S-specific cyclin-E1 | Homo sapiens | 2204 | Detail |
P04049 |
RAF1 | RAF proto-oncogene serine/threonine-protein kinase | Homo sapiens | 2133 | Detail |
P42338 |
PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 1951 | Detail |
Q00534 |
CDK6 | Cyclin-dependent kinase 6 | Homo sapiens | 1915 | Detail |
P06493 |
CDK1 | Cyclin-dependent kinase 1 | Homo sapiens | 1900 | Detail |
P01116 |
KRAS | GTPase KRas | Homo sapiens | 1811 | Detail |
Q16539 |
MAPK14 | Mitogen-activated protein kinase 14 | Homo sapiens | 1754 | Detail |
P24385 |
CCND1 | G1/S-specific cyclin-D1 | Homo sapiens | 1643 | Detail |
P31749 |
AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens | 1633 | Detail |
P20248 |
CCNA2 | Cyclin-A2 | Homo sapiens | 1415 | Detail |
Q00987 |
MDM2 | E3 ubiquitin-protein ligase Mdm2 | Homo sapiens | 1334 | Detail |
P04637 |
TP53 | Cellular tumor antigen p53 | Homo sapiens | 1173 | Detail |
P01111 |
NRAS | GTPase NRas | Homo sapiens | 923 | Detail |
P28482 |
MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens | 906 | Detail |
P31751 |
AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens | 896 | Detail |
Q13535 |
ATR | Serine/threonine-protein kinase ATR | Homo sapiens | 749 | Detail |
P78396 |
CCNA1 | Cyclin-A1 | Homo sapiens | 730 | Detail |
P30281 |
CCND3 | G1/S-specific cyclin-D3 | Homo sapiens | 656 | Detail |
O14757 |
CHEK1 | Serine/threonine-protein kinase Chk1 | Homo sapiens | 617 | Detail |
P53778 |
MAPK12 | Mitogen-activated protein kinase 12 | Homo sapiens | 606 | Detail |
Q15759 |
MAPK11 | Mitogen-activated protein kinase 11 | Homo sapiens | 594 | Detail |
P14635 |
CCNB1 | G2/mitotic-specific cyclin-B1 | Homo sapiens | 552 | Detail |
Q02750 |
MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens | 543 | Detail |
O15264 |
MAPK13 | Mitogen-activated protein kinase 13 | Homo sapiens | 533 | Detail |
O96020 |
CCNE2 | G1/S-specific cyclin-E2 | Homo sapiens | 504 | Detail |
O00459 |
PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | Homo sapiens | 485 | Detail |
P36897 |
TGFBR1 | TGF-beta receptor type-1 | Homo sapiens | 428 | Detail |
Q09028 |
RBBP4 | Histone-binding protein RBBP4 | Homo sapiens | 369 | Detail |
Q13541 |
EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein | Homo sapiens | 358 | Detail |
Q9Y243 |
AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens | 321 | Detail |
Q92569 |
PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | Homo sapiens | 289 | Detail |
Q9H2X6 |
HIPK2 | Homeodomain-interacting protein kinase 2 | Homo sapiens | 256 | Detail |
Q8WWL7 |
CCNB3 | G2/mitotic-specific cyclin-B3 | Homo sapiens | 242 | Detail |
O95067 |
CCNB2 | G2/mitotic-specific cyclin-B2 | Homo sapiens | 242 | Detail |
O96017 |
CHEK2 | Serine/threonine-protein kinase Chk2 | Homo sapiens | 237 | Detail |
P27361 |
MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens | 234 | Detail |
Q8NE63 |
HIPK4 | Homeodomain-interacting protein kinase 4 | Homo sapiens | 183 | Detail |
Q13315 |
ATM | Serine-protein kinase ATM | Homo sapiens | 170 | Detail |
P07384 |
CAPN1 | Calpain-1 catalytic subunit | Homo sapiens | 168 | Detail |
P36507 |
MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | Homo sapiens | 146 | Detail |
P37173 |
TGFBR2 | TGF-beta receptor type-2 | Homo sapiens | 144 | Detail |
P19838 |
NFKB1 | Nuclear factor NF-kappa-B p105 subunit | Homo sapiens | 140 | Detail |
Q04206 |
RELA | Transcription factor p65 | Homo sapiens | 134 | Detail |
P49137 |
MAPKAPK2 | MAP kinase-activated protein kinase 2 | Homo sapiens | 124 | Detail |
Q01668 |
CACNA1D | Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens | 117 | Detail |
P17655 |
CAPN2 | Calpain-2 catalytic subunit | Homo sapiens | 114 | Detail |
Q96EB6 |
SIRT1 | NAD-dependent protein deacetylase sirtuin-1 | Homo sapiens | 78 | Detail |
P30279 |
CCND2 | G1/S-specific cyclin-D2 | Homo sapiens | 71 | Detail |
Q86Z02 |
HIPK1 | Homeodomain-interacting protein kinase 1 | Homo sapiens | 44 | Detail |
Q9H422 |
HIPK3 | Homeodomain-interacting protein kinase 3 | Homo sapiens | 41 | Detail |
P48454 |
PPP3CC | Serine/threonine-protein phosphatase 2B catalytic subunit ga | Homo sapiens | 27 | Detail |
P01106 |
MYC | Myc proto-oncogene protein | Homo sapiens | 19 | Detail |
Q9HBA0 |
TRPV4 | Transient receptor potential cation channel subfamily V memb | Homo sapiens | 18 | Detail |
P05231 |
IL6 | Interleukin-6 | Homo sapiens | 17 | Detail |
P52564 |
MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | Homo sapiens | 17 | Detail |
P01112 |
HRAS | GTPase HRas | Homo sapiens | 14 | Detail |
P46734 |
MAP2K3 | Dual specificity mitogen-activated protein kinase kinase 3 | Homo sapiens | 12 | Detail |
P84022 |
SMAD3 | SMAD family member 3 | Homo sapiens | 11 | Detail |
Q15796 |
SMAD2 | SMAD family member 2 | Homo sapiens | 10 | Detail |
P10145 |
CXCL8 | Interleukin-8 | Homo sapiens | 9 | Detail |
P06400 |
RB1 | Retinoblastoma-associated protein | Homo sapiens | 8 | Detail |
P01137 |
TGFB1 | Transforming growth factor beta-1 proprotein | Homo sapiens | 8 | Detail |
P0DP23 |
CALM1 | Calmodulin-1 | Homo sapiens | 8 | Detail |
P36873 |
PPP1CC | Serine/threonine-protein phosphatase PP1-gamma catalytic sub | Homo sapiens | 5 | Detail |
P30304 |
CDC25A | M-phase inducer phosphatase 1 | Homo sapiens | 5 | Detail |
Q14643 |
ITPR1 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 | Homo sapiens | 4 | Detail |
Q14573 |
ITPR3 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 | Homo sapiens | 4 | Detail |
Q08209 |
PPP3CA | Protein phosphatase 3 catalytic subunit alpha | Homo sapiens | 4 | Detail |
P12236 |
SLC25A6 | ADP/ATP translocase 3 | Homo sapiens | 3 | Detail |
Q14571 |
ITPR2 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 | Homo sapiens | 3 | Detail |
Q08752 |
PPID | Peptidyl-prolyl cis-trans isomerase D | Homo sapiens | 3 | Detail |
Q08050 |
FOXM1 | Forkhead box protein M1 | Homo sapiens | 2 | Detail |
P05141 |
SLC25A5 | ADP/ATP translocase 2 | Homo sapiens | 2 | Detail |
P62136 |
PPP1CA | Serine/threonine-protein phosphatase PP1-alpha catalytic sub | Homo sapiens | 2 | Detail |
P61812 |
TGFB2 | Transforming growth factor beta-2 proprotein | Homo sapiens | 2 | Detail |
P21796 |
VDAC1 | Non-selective voltage-gated ion channel VDAC1 | Homo sapiens | 2 | Detail |
Q9Y277 |
VDAC3 | Non-selective voltage-gated ion channel VDAC3 | Homo sapiens | 2 | Detail |
Q92878 |
RAD50 | DNA repair protein RAD50 | Homo sapiens | 1 | Detail |
P38936 |
CDKN1A | Cyclin-dependent kinase inhibitor 1 | Homo sapiens | 1 | Detail |
P04439 |
HLA-A | HLA class I histocompatibility antigen, A alpha chain | Homo sapiens | 1 | Detail |
P01889 |
HLA-B | HLA class I histocompatibility antigen, B alpha chain | Homo sapiens | 1 | Detail |
P45880 |
VDAC2 | Non-selective voltage-gated ion channel VDAC2 | Homo sapiens | 1 | Detail |
Q13501 |
SQSTM1 | Sequestosome-1 | Homo sapiens | 1 | Detail |
Q8NE86 |
MCU | Calcium uniporter protein, mitochondrial | Homo sapiens | 1 | Detail |