Necroptosis
hsa04217 67 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
O60674 |
JAK2 | Tyrosine-protein kinase JAK2 | Homo sapiens | 10545 | Detail |
P23458 |
JAK1 | Tyrosine-protein kinase JAK1 | Homo sapiens | 8920 | Detail |
P52333 |
JAK3 | Tyrosine-protein kinase JAK3 | Homo sapiens | 5161 | Detail |
P29597 |
TYK2 | Non-receptor tyrosine-protein kinase TYK2 | Homo sapiens | 3837 | Detail |
P10415 |
BCL2 | Apoptosis regulator Bcl-2 | Homo sapiens | 1065 | Detail |
P98170 |
XIAP | E3 ubiquitin-protein ligase XIAP | Homo sapiens | 897 | Detail |
P09874 |
PARP1 | Poly [ADP-ribose] polymerase 1 | Homo sapiens | 886 | Detail |
Q13490 |
BIRC2 | Baculoviral IAP repeat-containing protein 2 | Homo sapiens | 876 | Detail |
P45983 |
MAPK8 | Mitogen-activated protein kinase 8 | Homo sapiens | 748 | Detail |
P45984 |
MAPK9 | Mitogen-activated protein kinase 9 | Homo sapiens | 676 | Detail |
P07900 |
HSP90AA1 | Heat shock protein HSP 90-alpha | Homo sapiens | 674 | Detail |
P53779 |
MAPK10 | Mitogen-activated protein kinase 10 | Homo sapiens | 625 | Detail |
P08238 |
HSP90AB1 | Heat shock protein HSP 90-beta | Homo sapiens | 602 | Detail |
Q13489 |
BIRC3 | Baculoviral IAP repeat-containing protein 3 | Homo sapiens | 532 | Detail |
Q13546 |
RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | Homo sapiens | 315 | Detail |
Q8NB16 |
MLKL | Mixed lineage kinase domain-like protein | Homo sapiens | 254 | Detail |
P62937 |
PPIA | Peptidyl-prolyl cis-trans isomerase A | Homo sapiens | 241 | Detail |
Q14790 |
CASP8 | Caspase-8 | Homo sapiens | 219 | Detail |
P29466 |
CASP1 | Caspase-1 | Homo sapiens | 173 | Detail |
P07384 |
CAPN1 | Calpain-1 catalytic subunit | Homo sapiens | 168 | Detail |
P15260 |
IFNGR1 | Interferon gamma receptor 1 | Homo sapiens | 150 | Detail |
Q13557 |
CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 150 | Detail |
P01584 |
IL1B | Interleukin-1 beta | Homo sapiens | 148 | Detail |
P01375 |
TNF | Tumor necrosis factor | Homo sapiens | 144 | Detail |
Q13555 |
CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 123 | Detail |
P17655 |
CAPN2 | Calpain-2 catalytic subunit | Homo sapiens | 114 | Detail |
Q9UQM7 |
CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 75 | Detail |
P06737 |
PYGL | Glycogen phosphorylase, liver form | Homo sapiens | 70 | Detail |
Q13554 |
CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 68 | Detail |
Q9Y572 |
RIPK3 | Receptor-interacting serine/threonine-protein kinase 3 | Homo sapiens | 67 | Detail |
P11217 |
PYGM | Glycogen phosphorylase, muscle form | Homo sapiens | 58 | Detail |
P40763 |
STAT3 | Signal transducer and activator of transcription 3 | Homo sapiens | 49 | Detail |
P49448 |
GLUD2 | Glutamate dehydrogenase 2, mitochondrial | Homo sapiens | 43 | Detail |
P55957 |
BID | BH3-interacting domain death agonist | Homo sapiens | 41 | Detail |
P19525 |
EIF2AK2 | Interferon-induced, double-stranded RNA-activated protein ki | Homo sapiens | 27 | Detail |
Q96P20 |
NLRP3 | NACHT, LRR and PYD domains-containing protein 3 | Homo sapiens | 16 | Detail |
P16050 |
ALOX15 | Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens | 14 | Detail |
P42229 |
STAT5A | Signal transducer and activator of transcription 5A | Homo sapiens | 11 | Detail |
P47712 |
PLA2G4A | Cytosolic phospholipase A2 | Homo sapiens | 10 | Detail |
P42226 |
STAT6 | Signal transducer and activator of transcription 6 | Homo sapiens | 10 | Detail |
O00206 |
TLR4 | Toll-like receptor 4 | Homo sapiens | 9 | Detail |
P04839 |
CYBB | NADPH oxidase 2 | Homo sapiens | 6 | Detail |
P51692 |
STAT5B | Signal transducer and activator of transcription 5B | Homo sapiens | 5 | Detail |
P42224 |
STAT1 | Signal transducer and activator of transcription 1-alpha/bet | Homo sapiens | 4 | Detail |
P0C869 |
PLA2G4B | Cytosolic phospholipase A2 beta | Homo sapiens | 3 | Detail |
P12236 |
SLC25A6 | ADP/ATP translocase 3 | Homo sapiens | 3 | Detail |
P09429 |
HMGB1 | High mobility group protein B1 | Homo sapiens | 3 | Detail |
Q08752 |
PPID | Peptidyl-prolyl cis-trans isomerase D | Homo sapiens | 3 | Detail |
P05141 |
SLC25A5 | ADP/ATP translocase 2 | Homo sapiens | 2 | Detail |
P19438 |
TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A | Homo sapiens | 2 | Detail |
P21796 |
VDAC1 | Non-selective voltage-gated ion channel VDAC1 | Homo sapiens | 2 | Detail |
Q9Y277 |
VDAC3 | Non-selective voltage-gated ion channel VDAC3 | Homo sapiens | 2 | Detail |
Q9UP65 |
PLA2G4C | Cytosolic phospholipase A2 gamma | Homo sapiens | 2 | Detail |
O95831 |
AIFM1 | Apoptosis-inducing factor 1, mitochondrial | Homo sapiens | 2 | Detail |
Q9BYM8 |
RBCK1 | RanBP-type and C3HC4-type zinc finger-containing protein 1 | Homo sapiens | 1 | Detail |
Q96HS1 |
PGAM5 | Serine/threonine-protein phosphatase PGAM5, mitochondrial | Homo sapiens | 1 | Detail |
Q9UK80 |
USP21 | Ubiquitin carboxyl-terminal hydrolase 21 | Homo sapiens | 1 | Detail |
Q96EP0 |
RNF31 | E3 ubiquitin-protein ligase RNF31 | Homo sapiens | 1 | Detail |
Q07812 |
BAX | Apoptosis regulator BAX | Homo sapiens | 1 | Detail |
P11216 |
PYGB | Glycogen phosphorylase, brain form | Homo sapiens | 1 | Detail |
Q14765 |
STAT4 | Signal transducer and activator of transcription 4 | Homo sapiens | 1 | Detail |
O15455 |
TLR3 | Toll-like receptor 3 | Homo sapiens | 1 | Detail |
Q12933 |
TRAF2 | TNF receptor-associated factor 2 | Homo sapiens | 1 | Detail |
P45880 |
VDAC2 | Non-selective voltage-gated ion channel VDAC2 | Homo sapiens | 1 | Detail |
Q9H0F6 |
SHARPIN | Sharpin | Homo sapiens | 1 | Detail |
O00220 |
TNFRSF10A | Tumor necrosis factor receptor superfamily member 10A | Homo sapiens | 1 | Detail |
Q13501 |
SQSTM1 | Sequestosome-1 | Homo sapiens | 1 | Detail |