Longevity regulating pathway
hsa04211 55 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
P42336 |
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 5616 | Detail |
O00329 |
PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 3772 | Detail |
P27986 |
PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | Homo sapiens | 2553 | Detail |
P42345 |
MTOR | Serine/threonine-protein kinase mTOR | Homo sapiens | 2517 | Detail |
P42338 |
PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 1951 | Detail |
P01116 |
KRAS | GTPase KRas | Homo sapiens | 1811 | Detail |
P31749 |
AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens | 1633 | Detail |
P23443 |
RPS6KB1 | Ribosomal protein S6 kinase beta-1 | Homo sapiens | 1180 | Detail |
P04637 |
TP53 | Cellular tumor antigen p53 | Homo sapiens | 1173 | Detail |
P01111 |
NRAS | GTPase NRas | Homo sapiens | 923 | Detail |
P31751 |
AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens | 896 | Detail |
P06213 |
INSR | Insulin receptor | Homo sapiens | 656 | Detail |
P08069 |
IGF1R | Insulin-like growth factor 1 receptor | Homo sapiens | 611 | Detail |
O00459 |
PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | Homo sapiens | 485 | Detail |
P17612 |
PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | Homo sapiens | 453 | Detail |
P37231 |
PPARG | Peroxisome proliferator-activated receptor gamma | Homo sapiens | 417 | Detail |
Q13541 |
EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein | Homo sapiens | 358 | Detail |
Q9Y243 |
AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens | 321 | Detail |
Q92569 |
PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | Homo sapiens | 289 | Detail |
Q13131 |
PRKAA1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | Homo sapiens | 282 | Detail |
Q8N122 |
RPTOR | Regulatory-associated protein of mTOR | Homo sapiens | 189 | Detail |
Q96KQ7 |
EHMT2 | Histone-lysine N-methyltransferase EHMT2 | Homo sapiens | 185 | Detail |
P19838 |
NFKB1 | Nuclear factor NF-kappa-B p105 subunit | Homo sapiens | 140 | Detail |
Q04206 |
RELA | Transcription factor p65 | Homo sapiens | 134 | Detail |
P22694 |
PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Homo sapiens | 121 | Detail |
P22612 |
PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | Homo sapiens | 111 | Detail |
Q9H9B1 |
EHMT1 | Histone-lysine N-methyltransferase EHMT1 | Homo sapiens | 109 | Detail |
P54619 |
PRKAG1 | 5'-AMP-activated protein kinase subunit gamma-1 | Homo sapiens | 83 | Detail |
Q96RR4 |
CAMKK2 | Calcium/calmodulin-dependent protein kinase kinase 2 | Homo sapiens | 81 | Detail |
Q96EB6 |
SIRT1 | NAD-dependent protein deacetylase sirtuin-1 | Homo sapiens | 78 | Detail |
P54646 |
PRKAA2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | Homo sapiens | 75 | Detail |
Q9Y478 |
PRKAB1 | 5'-AMP-activated protein kinase subunit beta-1 | Homo sapiens | 65 | Detail |
O75385 |
ULK1 | Serine/threonine-protein kinase ULK1 | Homo sapiens | 55 | Detail |
P06730 |
EIF4E | Eukaryotic translation initiation factor 4E | Homo sapiens | 46 | Detail |
O43741 |
PRKAB2 | 5'-AMP-activated protein kinase subunit beta-2 | Homo sapiens | 45 | Detail |
Q9UGJ0 |
PRKAG2 | 5'-AMP-activated protein kinase subunit gamma-2 | Homo sapiens | 44 | Detail |
Q08828 |
ADCY1 | Adenylate cyclase type 1 | Homo sapiens | 30 | Detail |
Q9UGI9 |
PRKAG3 | 5'-AMP-activated protein kinase subunit gamma-3 | Homo sapiens | 30 | Detail |
P40145 |
ADCY8 | Adenylate cyclase type 8 | Homo sapiens | 27 | Detail |
O95622 |
ADCY5 | Adenylate cyclase type 5 | Homo sapiens | 23 | Detail |
Q96B36 |
AKT1S1 | Proline-rich AKT1 substrate 1 | Homo sapiens | 22 | Detail |
Q08462 |
ADCY2 | Adenylate cyclase type 2 | Homo sapiens | 21 | Detail |
O60266 |
ADCY3 | Adenylate cyclase type 3 | Homo sapiens | 21 | Detail |
O43306 |
ADCY6 | Adenylate cyclase type 6 | Homo sapiens | 21 | Detail |
P51828 |
ADCY7 | Adenylate cyclase type 7 | Homo sapiens | 21 | Detail |
O60503 |
ADCY9 | Adenylate cyclase type 9 | Homo sapiens | 21 | Detail |
Q8NFM4 |
ADCY4 | Adenylate cyclase type 4 | Homo sapiens | 21 | Detail |
Q15831 |
STK11 | Serine/threonine-protein kinase STK11 | Homo sapiens | 17 | Detail |
P01112 |
HRAS | GTPase HRas | Homo sapiens | 14 | Detail |
Q16566 |
CAMK4 | Calcium/calmodulin-dependent protein kinase type IV | Homo sapiens | 14 | Detail |
Q9UBS0 |
RPS6KB2 | Ribosomal protein S6 kinase beta-2 | Homo sapiens | 13 | Detail |
P35568 |
IRS1 | Insulin receptor substrate 1 | Homo sapiens | 2 | Detail |
Q07812 |
BAX | Apoptosis regulator BAX | Homo sapiens | 1 | Detail |
P04040 |
CAT | Catalase | Homo sapiens | 1 | Detail |
O75143 |
ATG13 | Autophagy-related protein 13 | Homo sapiens | 1 | Detail |