Apoptosis
hsa04210 101 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
P42336 |
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 5616 | Detail |
O00329 |
PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 3772 | Detail |
P27986 |
PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | Homo sapiens | 2553 | Detail |
P04049 |
RAF1 | RAF proto-oncogene serine/threonine-protein kinase | Homo sapiens | 2133 | Detail |
Q07820 |
MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Homo sapiens | 2063 | Detail |
P42338 |
PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 1951 | Detail |
O43521 |
BCL2L11 | Bcl-2-like protein 11 | Homo sapiens | 1888 | Detail |
P01116 |
KRAS | GTPase KRas | Homo sapiens | 1811 | Detail |
P31749 |
AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens | 1633 | Detail |
P04637 |
TP53 | Cellular tumor antigen p53 | Homo sapiens | 1173 | Detail |
P04629 |
NTRK1 | High affinity nerve growth factor receptor | Homo sapiens | 1127 | Detail |
P10415 |
BCL2 | Apoptosis regulator Bcl-2 | Homo sapiens | 1065 | Detail |
Q07817 |
BCL2L1 | Bcl-2-like protein 1 | Homo sapiens | 990 | Detail |
P07711 |
CTSL | Procathepsin L | Homo sapiens | 975 | Detail |
P25774 |
CTSS | Cathepsin S | Homo sapiens | 925 | Detail |
P01111 |
NRAS | GTPase NRas | Homo sapiens | 923 | Detail |
P28482 |
MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens | 906 | Detail |
P98170 |
XIAP | E3 ubiquitin-protein ligase XIAP | Homo sapiens | 897 | Detail |
P31751 |
AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens | 896 | Detail |
P09874 |
PARP1 | Poly [ADP-ribose] polymerase 1 | Homo sapiens | 886 | Detail |
Q13490 |
BIRC2 | Baculoviral IAP repeat-containing protein 2 | Homo sapiens | 876 | Detail |
P43235 |
CTSK | Cathepsin K | Homo sapiens | 835 | Detail |
P45983 |
MAPK8 | Mitogen-activated protein kinase 8 | Homo sapiens | 748 | Detail |
P45984 |
MAPK9 | Mitogen-activated protein kinase 9 | Homo sapiens | 676 | Detail |
P53779 |
MAPK10 | Mitogen-activated protein kinase 10 | Homo sapiens | 625 | Detail |
Q9UGN5 |
PARP2 | Poly [ADP-ribose] polymerase 2 | Homo sapiens | 571 | Detail |
P07339 |
CTSD | Cathepsin D | Homo sapiens | 551 | Detail |
Q02750 |
MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens | 543 | Detail |
Q13489 |
BIRC3 | Baculoviral IAP repeat-containing protein 3 | Homo sapiens | 532 | Detail |
P07858 |
CTSB | Cathepsin B | Homo sapiens | 494 | Detail |
O00459 |
PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | Homo sapiens | 485 | Detail |
P42574 |
CASP3 | Caspase-3 | Homo sapiens | 444 | Detail |
O14920 |
IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | Homo sapiens | 411 | Detail |
Q9Y243 |
AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens | 321 | Detail |
Q13546 |
RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | Homo sapiens | 315 | Detail |
P55210 |
CASP7 | Caspase-7 | Homo sapiens | 306 | Detail |
Q92569 |
PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | Homo sapiens | 289 | Detail |
P68366 |
TUBA4A | Tubulin alpha-4A chain | Homo sapiens | 268 | Detail |
Q71U36 |
TUBA1A | Tubulin alpha-1A chain | Homo sapiens | 267 | Detail |
Q9BQE3 |
TUBA1C | Tubulin alpha-1C chain | Homo sapiens | 267 | Detail |
P68363 |
TUBA1B | Tubulin alpha-1B chain | Homo sapiens | 266 | Detail |
Q6PEY2 |
TUBA3E | Tubulin alpha-3E chain | Homo sapiens | 266 | Detail |
P0DPH7 |
TUBA3C | Tubulin alpha-3C chain | Homo sapiens | 266 | Detail |
P27361 |
MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens | 234 | Detail |
O15530 |
PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | Homo sapiens | 228 | Detail |
Q99558 |
MAP3K14 | Mitogen-activated protein kinase kinase kinase 14 | Homo sapiens | 224 | Detail |
Q14790 |
CASP8 | Caspase-8 | Homo sapiens | 219 | Detail |
O15111 |
CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | Homo sapiens | 170 | Detail |
Q13315 |
ATM | Serine-protein kinase ATM | Homo sapiens | 170 | Detail |
P07384 |
CAPN1 | Calpain-1 catalytic subunit | Homo sapiens | 168 | Detail |
Q9NZJ5 |
EIF2AK3 | Eukaryotic translation initiation factor 2-alpha kinase 3 | Homo sapiens | 154 | Detail |
P36507 |
MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | Homo sapiens | 146 | Detail |
P01375 |
TNF | Tumor necrosis factor | Homo sapiens | 144 | Detail |
P19838 |
NFKB1 | Nuclear factor NF-kappa-B p105 subunit | Homo sapiens | 140 | Detail |
Q04206 |
RELA | Transcription factor p65 | Homo sapiens | 134 | Detail |
P17655 |
CAPN2 | Calpain-2 catalytic subunit | Homo sapiens | 114 | Detail |
P55212 |
CASP6 | Caspase-6 | Homo sapiens | 112 | Detail |
Q99683 |
MAP3K5 | Mitogen-activated protein kinase kinase kinase 5 | Homo sapiens | 81 | Detail |
O60911 |
CTSV | Cathepsin L2 | Homo sapiens | 70 | Detail |
P05412 |
JUN | Transcription factor Jun | Homo sapiens | 69 | Detail |
Q16548 |
BCL2A1 | Bcl-2-related protein A1 | Homo sapiens | 59 | Detail |
O75460 |
ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | Homo sapiens | 46 | Detail |
Q9Y6F1 |
PARP3 | Protein mono-ADP-ribosyltransferase PARP3 | Homo sapiens | 41 | Detail |
P55957 |
BID | BH3-interacting domain death agonist | Homo sapiens | 41 | Detail |
P53634 |
CTSC | Dipeptidyl peptidase 1 | Homo sapiens | 33 | Detail |
P55211 |
CASP9 | Caspase-9 | Homo sapiens | 32 | Detail |
Q92934 |
BAD | Bcl2-associated agonist of cell death | Homo sapiens | 27 | Detail |
Q9UBX1 |
CTSF | Cathepsin F | Homo sapiens | 26 | Detail |
P01100 |
FOS | Protein c-Fos | Homo sapiens | 25 | Detail |
P05198 |
EIF2S1 | Eukaryotic translation initiation factor 2 subunit 1 | Homo sapiens | 22 | Detail |
P09668 |
CTSH | Pro-cathepsin H | Homo sapiens | 19 | Detail |
P42575 |
CASP2 | Caspase-2 | Homo sapiens | 16 | Detail |
P01112 |
HRAS | GTPase HRas | Homo sapiens | 14 | Detail |
Q9Y6K9 |
IKBKG | NF-kappa-B essential modulator | Homo sapiens | 13 | Detail |
Q9UKK3 |
PARP4 | Protein mono-ADP-ribosyltransferase PARP4 | Homo sapiens | 11 | Detail |
Q92851 |
CASP10 | Caspase-10 | Homo sapiens | 10 | Detail |
O43464 |
HTRA2 | Serine protease HTRA2, mitochondrial | Homo sapiens | 6 | Detail |
Q16611 |
BAK1 | Bcl-2 homologous antagonist/killer | Homo sapiens | 6 | Detail |
O14727 |
APAF1 | Apoptotic protease-activating factor 1 | Homo sapiens | 5 | Detail |
P10144 |
GZMB | Granzyme B | Homo sapiens | 4 | Detail |
Q14643 |
ITPR1 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 | Homo sapiens | 4 | Detail |
Q14573 |
ITPR3 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 | Homo sapiens | 4 | Detail |
Q14571 |
ITPR2 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 | Homo sapiens | 3 | Detail |
Q9UBR2 |
CTSZ | Cathepsin Z | Homo sapiens | 2 | Detail |
P20700 |
LMNB1 | Lamin-B1 | Homo sapiens | 2 | Detail |
Q9NY65 |
TUBA8 | Tubulin alpha-8 chain | Homo sapiens | 2 | Detail |
Q13813 |
SPTAN1 | Spectrin alpha chain, non-erythrocytic 1 | Homo sapiens | 2 | Detail |
P19438 |
TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A | Homo sapiens | 2 | Detail |
A6NHL2 |
TUBAL3 | Tubulin alpha chain-like 3 | Homo sapiens | 2 | Detail |
O95831 |
AIFM1 | Apoptosis-inducing factor 1, mitochondrial | Homo sapiens | 2 | Detail |
Q5VWQ8 |
DAB2IP | Disabled homolog 2-interacting protein | Homo sapiens | 1 | Detail |
Q9BXH1 |
BBC3 | Bcl-2-binding component 3, isoforms 1/2 | Homo sapiens | 1 | Detail |
P02545 |
LMNA | Prelamin-A/C | Homo sapiens | 1 | Detail |
P25963 |
NFKBIA | NF-kappa-B inhibitor alpha | Homo sapiens | 1 | Detail |
P01138 |
NGF | Beta-nerve growth factor | Homo sapiens | 1 | Detail |
Q13794 |
PMAIP1 | Phorbol-12-myristate-13-acetate-induced protein 1 | Homo sapiens | 1 | Detail |
P99999 |
CYCS | Cytochrome c | Homo sapiens | 1 | Detail |
Q12923 |
PTPN13 | Tyrosine-protein phosphatase non-receptor type 13 | Homo sapiens | 1 | Detail |
Q07812 |
BAX | Apoptosis regulator BAX | Homo sapiens | 1 | Detail |
Q12933 |
TRAF2 | TNF receptor-associated factor 2 | Homo sapiens | 1 | Detail |
O00220 |
TNFRSF10A | Tumor necrosis factor receptor superfamily member 10A | Homo sapiens | 1 | Detail |