PI3K-Akt signaling pathway

hsa04151 154 targets in this pathway

UniProt AC Gene Protein Name Organism Multi-Target Molecules
O60674 JAK2 Tyrosine-protein kinase JAK2 Homo sapiens 10545 Detail
P23458 JAK1 Tyrosine-protein kinase JAK1 Homo sapiens 8920 Detail
P35968 KDR Vascular endothelial growth factor receptor 2 Homo sapiens 5667 Detail
P42336 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub Homo sapiens 5616 Detail
P24941 CDK2 Cyclin-dependent kinase 2 Homo sapiens 5432 Detail
P52333 JAK3 Tyrosine-protein kinase JAK3 Homo sapiens 5161 Detail
O00329 PIK3CD Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub Homo sapiens 3772 Detail
P00533 EGFR Epidermal growth factor receptor Homo sapiens 3433 Detail
P11362 FGFR1 Fibroblast growth factor receptor 1 Homo sapiens 3320 Detail
P11802 CDK4 Cyclin-dependent kinase 4 Homo sapiens 2896 Detail
P22607 FGFR3 Fibroblast growth factor receptor 3 Homo sapiens 2742 Detail
P27986 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha Homo sapiens 2553 Detail
P42345 MTOR Serine/threonine-protein kinase mTOR Homo sapiens 2517 Detail
P05106 ITGB3 Integrin beta-3 Homo sapiens 2474 Detail
P48736 PIK3CG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub Homo sapiens 2398 Detail
P49841 GSK3B Glycogen synthase kinase-3 beta Homo sapiens 2206 Detail
P24864 CCNE1 G1/S-specific cyclin-E1 Homo sapiens 2204 Detail
P36888 FLT3 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens 2188 Detail
P04049 RAF1 RAF proto-oncogene serine/threonine-protein kinase Homo sapiens 2133 Detail
P21802 FGFR2 Fibroblast growth factor receptor 2 Homo sapiens 2130 Detail
P04626 ERBB2 Receptor tyrosine-protein kinase erbB-2 Homo sapiens 2123 Detail
Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Homo sapiens 2063 Detail
P42338 PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub Homo sapiens 1951 Detail
Q00534 CDK6 Cyclin-dependent kinase 6 Homo sapiens 1915 Detail
O43521 BCL2L11 Bcl-2-like protein 11 Homo sapiens 1888 Detail
P01116 KRAS GTPase KRas Homo sapiens 1811 Detail
P08172 CHRM2 Muscarinic acetylcholine receptor M2 Homo sapiens 1645 Detail
P24385 CCND1 G1/S-specific cyclin-D1 Homo sapiens 1643 Detail
P31749 AKT1 RAC-alpha serine/threonine-protein kinase Homo sapiens 1633 Detail
P06756 ITGAV Integrin alpha-V Homo sapiens 1632 Detail
P05556 ITGB1 Integrin beta-1 Homo sapiens 1572 Detail
P11229 CHRM1 Muscarinic acetylcholine receptor M1 Homo sapiens 1571 Detail
P09619 PDGFRB Platelet-derived growth factor receptor beta Homo sapiens 1527 Detail
P22455 FGFR4 Fibroblast growth factor receptor 4 Homo sapiens 1506 Detail
Q00987 MDM2 E3 ubiquitin-protein ligase Mdm2 Homo sapiens 1334 Detail
P08514 ITGA2B Integrin alpha-IIb Homo sapiens 1322 Detail
P13612 ITGA4 Integrin alpha-4 Homo sapiens 1260 Detail
P17948 FLT1 Vascular endothelial growth factor receptor 1 Homo sapiens 1237 Detail
P23443 RPS6KB1 Ribosomal protein S6 kinase beta-1 Homo sapiens 1180 Detail
P04637 TP53 Cellular tumor antigen p53 Homo sapiens 1173 Detail
P10721 KIT Mast/stem cell growth factor receptor Kit Homo sapiens 1134 Detail
P04629 NTRK1 High affinity nerve growth factor receptor Homo sapiens 1127 Detail
P08581 MET Hepatocyte growth factor receptor Homo sapiens 1125 Detail
P10415 BCL2 Apoptosis regulator Bcl-2 Homo sapiens 1065 Detail
Q07817 BCL2L1 Bcl-2-like protein 1 Homo sapiens 990 Detail
P01111 NRAS GTPase NRas Homo sapiens 923 Detail
P28482 MAPK1 Mitogen-activated protein kinase 1 Homo sapiens 906 Detail
P07333 CSF1R Macrophage colony-stimulating factor 1 receptor Homo sapiens 896 Detail
P31751 AKT2 RAC-beta serine/threonine-protein kinase Homo sapiens 896 Detail
P16234 PDGFRA Platelet-derived growth factor receptor alpha Homo sapiens 860 Detail
P43405 SYK Tyrosine-protein kinase SYK Homo sapiens 852 Detail
Q07889 SOS1 Son of sevenless homolog 1 Homo sapiens 766 Detail
P19793 RXRA Retinoic acid receptor RXR-alpha Homo sapiens 702 Detail
P17252 PRKCA Protein kinase C alpha type Homo sapiens 679 Detail
P07900 HSP90AA1 Heat shock protein HSP 90-alpha Homo sapiens 674 Detail
P06213 INSR Insulin receptor Homo sapiens 656 Detail
P07949 RET Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens 656 Detail
P30281 CCND3 G1/S-specific cyclin-D3 Homo sapiens 656 Detail
P35916 FLT4 Vascular endothelial growth factor receptor 3 Homo sapiens 636 Detail
P08069 IGF1R Insulin-like growth factor 1 receptor Homo sapiens 611 Detail
P08238 HSP90AB1 Heat shock protein HSP 90-beta Homo sapiens 602 Detail
Q02750 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens 543 Detail
P29317 EPHA2 Ephrin type-A receptor 2 Homo sapiens 540 Detail
Q16620 NTRK2 BDNF/NT-3 growth factors receptor Homo sapiens 538 Detail
Q02763 TEK Angiopoietin-1 receptor Homo sapiens 507 Detail
O96020 CCNE2 G1/S-specific cyclin-E2 Homo sapiens 504 Detail
O00459 PIK3R2 Phosphatidylinositol 3-kinase regulatory subunit beta Homo sapiens 485 Detail
P18564 ITGB6 Integrin beta-6 Homo sapiens 451 Detail
O14920 IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta Homo sapiens 411 Detail
P18084 ITGB5 Integrin beta-5 Homo sapiens 402 Detail
P08648 ITGA5 Integrin alpha-5 Homo sapiens 366 Detail
Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein Homo sapiens 358 Detail
P26010 ITGB7 Integrin beta-7 Homo sapiens 355 Detail
Q15303 ERBB4 Receptor tyrosine-protein kinase erbB-4 Homo sapiens 336 Detail
Q05397 PTK2 Focal adhesion kinase 1 Homo sapiens 325 Detail
Q9Y243 AKT3 RAC-gamma serine/threonine-protein kinase Homo sapiens 321 Detail
Q8WYR1 PIK3R5 Phosphoinositide 3-kinase regulatory subunit 5 Homo sapiens 297 Detail
Q92569 PIK3R3 Phosphatidylinositol 3-kinase regulatory subunit gamma Homo sapiens 289 Detail
Q13131 PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens 282 Detail
P27361 MAPK3 Mitogen-activated protein kinase 3 Homo sapiens 234 Detail
O15530 PDPK1 3-phosphoinositide-dependent protein kinase 1 Homo sapiens 228 Detail
Q16513 PKN2 Serine/threonine-protein kinase N2 Homo sapiens 219 Detail
Q9BVC4 MLST8 Target of rapamycin complex subunit LST8 Homo sapiens 219 Detail
Q8N122 RPTOR Regulatory-associated protein of mTOR Homo sapiens 189 Detail
O15111 CHUK Inhibitor of nuclear factor kappa-B kinase subunit alpha Homo sapiens 170 Detail
P26012 ITGB8 Integrin beta-8 Homo sapiens 163 Detail
P05112 IL4 Interleukin-4 Homo sapiens 146 Detail
P36507 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 Homo sapiens 146 Detail
P19838 NFKB1 Nuclear factor NF-kappa-B p105 subunit Homo sapiens 140 Detail
Q04206 RELA Transcription factor p65 Homo sapiens 134 Detail
Q92633 LPAR1 Lysophosphatidic acid receptor 1 Homo sapiens 122 Detail
P21860 ERBB3 Receptor tyrosine-protein kinase erbB-3 Homo sapiens 109 Detail
Q9HBY8 SGK2 Serine/threonine-protein kinase Sgk2 Homo sapiens 99 Detail
P29474 NOS3 Nitric oxide synthase 3 Homo sapiens 94 Detail
Q9H1C0 LPAR5 Lysophosphatidic acid receptor 5 Homo sapiens 80 Detail
P54646 PRKAA2 5'-AMP-activated protein kinase catalytic subunit alpha-2 Homo sapiens 75 Detail
P30279 CCND2 G1/S-specific cyclin-D2 Homo sapiens 71 Detail
P09038 FGF2 Fibroblast growth factor 2 Homo sapiens 69 Detail
P14625 HSP90B1 Endoplasmin Homo sapiens 67 Detail
P17301 ITGA2 Integrin alpha-2 Homo sapiens 65 Detail
Q16512 PKN1 Serine/threonine-protein kinase N1 Homo sapiens 60 Detail
P06730 EIF4E Eukaryotic translation initiation factor 4E Homo sapiens 46 Detail
P05230 FGF1 Fibroblast growth factor 1 Homo sapiens 45 Detail
P15692 VEGFA Vascular endothelial growth factor A, long form Homo sapiens 44 Detail
P25116 F2R Proteinase-activated receptor 1 Homo sapiens 37 Detail
Q9UBY5 LPAR3 Lysophosphatidic acid receptor 3 Homo sapiens 36 Detail
O00141 SGK1 Serine/threonine-protein kinase Sgk1 Homo sapiens 34 Detail
Q9HBW0 LPAR2 Lysophosphatidic acid receptor 2 Homo sapiens 33 Detail
P55211 CASP9 Caspase-9 Homo sapiens 32 Detail
P60568 IL2 Interleukin-2 Homo sapiens 29 Detail
Q92934 BAD Bcl2-associated agonist of cell death Homo sapiens 27 Detail
P53708 ITGA8 Integrin alpha-8 Homo sapiens 21 Detail
P01106 MYC Myc proto-oncogene protein Homo sapiens 19 Detail
P05231 IL6 Interleukin-6 Homo sapiens 17 Detail
Q15831 STK11 Serine/threonine-protein kinase STK11 Homo sapiens 17 Detail
Q96BR1 SGK3 Serine/threonine-protein kinase Sgk3 Homo sapiens 16 Detail
P01127 PDGFB Platelet-derived growth factor subunit B Homo sapiens 16 Detail
P01112 HRAS GTPase HRas Homo sapiens 14 Detail
O60603 TLR2 Toll-like receptor 2 Homo sapiens 14 Detail
P62753 RPS6 Small ribosomal subunit protein eS6 Homo sapiens 13 Detail
Q9UBS0 RPS6KB2 Ribosomal protein S6 kinase beta-2 Homo sapiens 13 Detail
Q9Y6K9 IKBKG NF-kappa-B essential modulator Homo sapiens 13 Detail
O00206 TLR4 Toll-like receptor 4 Homo sapiens 9 Detail
P15514 AREG Amphiregulin Homo sapiens 7 Detail
P56199 ITGA1 Integrin alpha-1 Homo sapiens 6 Detail
Q16543 CDC37 Hsp90 co-chaperone Cdc37 Homo sapiens 5 Detail
P67775 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit al Homo sapiens 5 Detail
P62993 GRB2 Growth factor receptor-bound protein 2 Homo sapiens 4 Detail
Q6P5Z2 PKN3 Serine/threonine-protein kinase N3 Homo sapiens 4 Detail
P14210 HGF Hepatocyte growth factor Homo sapiens 4 Detail
P22736 NR4A1 Nuclear receptor subfamily 4immunitygroup A member 1 Homo sapiens 4 Detail
Q15172 PPP2R5A Serine/threonine-protein phosphatase 2A 56 kDa regulatory su Homo sapiens 4 Detail
O60346 PHLPP1 PH domain leucine-rich repeat-containing protein phosphatase Homo sapiens 3 Detail
P02751 FN1 Fibronectin Homo sapiens 3 Detail
P49763 PGF Placenta growth factor Homo sapiens 3 Detail
P63000 RAC1 Ras-related C3 botulinum toxin substrate 1 Homo sapiens 3 Detail
P61981 YWHAG 14-3-3 protein gamma Homo sapiens 3 Detail
Q04917 YWHAH 14-3-3 protein eta Homo sapiens 3 Detail
P27348 YWHAQ 14-3-3 protein theta Homo sapiens 2 Detail
P23588 EIF4B Eukaryotic translation initiation factor 4B Homo sapiens 2 Detail
P62873 GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit be Homo sapiens 2 Detail
Q99677 LPAR4 Lysophosphatidic acid receptor 4 Homo sapiens 2 Detail
P35568 IRS1 Insulin receptor substrate 1 Homo sapiens 2 Detail
Q16822 PCK2 Phosphoenolpyruvate carboxykinase [GTP], mitochondrial Homo sapiens 2 Detail
P59768 GNG2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit ga Homo sapiens 2 Detail
P63151 PPP2R2A Serine/threonine-protein phosphatase 2A 55 kDa regulatory su Homo sapiens 2 Detail
P31946 YWHAB 14-3-3 protein beta/alpha Homo sapiens 2 Detail
P38936 CDKN1A Cyclin-dependent kinase inhibitor 1 Homo sapiens 1 Detail
P02458 COL2A1 Collagen alpha-1(II) chain Homo sapiens 1 Detail
P23229 ITGA6 Integrin alpha-6 Homo sapiens 1 Detail
P01138 NGF Beta-nerve growth factor Homo sapiens 1 Detail
P04085 PDGFA Platelet-derived growth factor subunit A Homo sapiens 1 Detail
P62258 YWHAE 14-3-3 protein epsilon Homo sapiens 1 Detail
P63104 YWHAZ 14-3-3 protein zeta/delta Homo sapiens 1 Detail