Ubiquitin mediated proteolysis

hsa04120 42 targets in this pathway

UniProt AC Gene Protein Name Organism Multi-Target Molecules
Q00987 MDM2 E3 ubiquitin-protein ligase Mdm2 Homo sapiens 1334 Detail
P98170 XIAP E3 ubiquitin-protein ligase XIAP Homo sapiens 897 Detail
Q13490 BIRC2 Baculoviral IAP repeat-containing protein 2 Homo sapiens 876 Detail
Q13191 CBLB E3 ubiquitin-protein ligase CBL-B Homo sapiens 746 Detail
Q9ULV8 CBLC E3 ubiquitin-protein ligase CBL-C Homo sapiens 690 Detail
Q14145 KEAP1 Kelch-like ECH-associated protein 1 Homo sapiens 558 Detail
Q13489 BIRC3 Baculoviral IAP repeat-containing protein 3 Homo sapiens 532 Detail
Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 Homo sapiens 188 Detail
Q16531 DDB1 DNA damage-binding protein 1 Homo sapiens 170 Detail
P61081 UBE2M NEDD8-conjugating enzyme Ubc12 Homo sapiens 165 Detail
P40337 VHL von Hippel-Lindau disease tumor suppressor Homo sapiens 158 Detail
Q8TBC4 UBA3 NEDD8-activating enzyme E1 catalytic subunit Homo sapiens 127 Detail
Q9UBT2 UBA2 SUMO-activating enzyme subunit 2 Homo sapiens 111 Detail
Q15369 ELOC Elongin-C Homo sapiens 86 Detail
Q15370 ELOB Elongin-B Homo sapiens 85 Detail
Q9UBE0 SAE1 SUMO-activating enzyme subunit 1 Homo sapiens 84 Detail
Q13617 CUL2 Cullin-2 Homo sapiens 42 Detail
P22314 UBA1 Ubiquitin-like modifier-activating enzyme 1 Homo sapiens 30 Detail
P51965 UBE2E1 Ubiquitin-conjugating enzyme E2 E1 Homo sapiens 27 Detail
P22681 CBL E3 ubiquitin-protein ligase CBL Homo sapiens 16 Detail
P62979 RPS27A Ubiquitin-ribosomal protein eS31 fusion protein Homo sapiens 12 Detail
Q96CA5 BIRC7 Baculoviral IAP repeat-containing protein 7 Homo sapiens 12 Detail
P63279 UBE2I SUMO-conjugating enzyme UBC9 Homo sapiens 8 Detail
Q969M7 UBE2F NEDD8-conjugating enzyme UBE2F Homo sapiens 7 Detail
Q13309 SKP2 S-phase kinase-associated protein 2 Homo sapiens 7 Detail
Q9HCE7 SMURF1 E3 ubiquitin-protein ligase SMURF1 Homo sapiens 5 Detail
Q9HAU4 SMURF2 E3 ubiquitin-protein ligase SMURF2 Homo sapiens 5 Detail
P61088 UBE2N Ubiquitin-conjugating enzyme E2 N Homo sapiens 2 Detail
Q86TM6 SYVN1 E3 ubiquitin-protein ligase synoviolin Homo sapiens 2 Detail
Q13618 CUL3 Cullin-3 Homo sapiens 2 Detail
Q13616 CUL1 Cullin-1 Homo sapiens 2 Detail
Q15386 UBE3C Ubiquitin-protein ligase E3C Homo sapiens 2 Detail
Q9UNE7 STUB1 E3 ubiquitin-protein ligase CHIP Homo sapiens 1 Detail
Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 Homo sapiens 1 Detail
A0AVT1 UBA6 Ubiquitin-like modifier-activating enzyme 6 Homo sapiens 1 Detail
P63208 SKP1 S-phase kinase-associated protein 1 Homo sapiens 1 Detail
P60604 UBE2G2 Ubiquitin-conjugating enzyme E2 G2 Homo sapiens 1 Detail
P68036 UBE2L3 Ubiquitin-conjugating enzyme E2 L3 Homo sapiens 1 Detail
Q93034 CUL5 Cullin-5 Homo sapiens 1 Detail
Q9UJX2 CDC23 Cell division cycle protein 23 homolog Homo sapiens 1 Detail
Q13042 CDC16 Cell division cycle protein 16 homolog Homo sapiens 1 Detail
Q14139 UBE4A Ubiquitin conjugation factor E4 A Homo sapiens 1 Detail