Neuroactive ligand signaling
hsa04082 156 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
P14416 |
DRD2 | D(2) dopamine receptor | Homo sapiens | 6392 | Detail |
P18505 |
GABRB1 | Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens | 5316 | Detail |
P28223 |
HTR2A | 5-hydroxytryptamine receptor 2A | Homo sapiens | 4720 | Detail |
P35372 |
OPRM1 | Mu-type opioid receptor | Homo sapiens | 4568 | Detail |
P35462 |
DRD3 | D(3) dopamine receptor | Homo sapiens | 4507 | Detail |
P29274 |
ADORA2A | Adenosine receptor A2a | Homo sapiens | 4217 | Detail |
P31645 |
SLC6A4 | Sodium-dependent serotonin transporter | Homo sapiens | 3668 | Detail |
P08908 |
HTR1A | 5-hydroxytryptamine receptor 1A | Homo sapiens | 3572 | Detail |
P30542 |
ADORA1 | Adenosine receptor A1 | Homo sapiens | 3399 | Detail |
P41145 |
OPRK1 | Kappa-type opioid receptor | Homo sapiens | 2903 | Detail |
P41143 |
OPRD1 | Delta-type opioid receptor | Homo sapiens | 2616 | Detail |
P28335 |
HTR2C | 5-hydroxytryptamine receptor 2C | Homo sapiens | 2557 | Detail |
P29275 |
ADORA2B | Adenosine receptor A2b | Homo sapiens | 2516 | Detail |
P23975 |
SLC6A2 | Sodium-dependent noradrenaline transporter | Homo sapiens | 2491 | Detail |
P0DMS8 |
ADORA3 | Adenosine receptor A3 | Homo sapiens | 2190 | Detail |
Q01959 |
SLC6A3 | Sodium-dependent dopamine transporter | Homo sapiens | 1959 | Detail |
Q05586 |
GRIN1 | Glutamate receptor ionotropic, NMDA 1 | Homo sapiens | 1847 | Detail |
Q13224 |
GRIN2B | Glutamate receptor ionotropic, NMDA 2B | Homo sapiens | 1823 | Detail |
P21917 |
DRD4 | D(4) dopamine receptor | Homo sapiens | 1796 | Detail |
P34969 |
HTR7 | 5-hydroxytryptamine receptor 7 | Homo sapiens | 1724 | Detail |
P35348 |
ADRA1A | Alpha-1A adrenergic receptor | Homo sapiens | 1709 | Detail |
P08172 |
CHRM2 | Muscarinic acetylcholine receptor M2 | Homo sapiens | 1645 | Detail |
P11229 |
CHRM1 | Muscarinic acetylcholine receptor M1 | Homo sapiens | 1571 | Detail |
P41146 |
OPRL1 | Nociceptin receptor | Homo sapiens | 1506 | Detail |
P41595 |
HTR2B | 5-hydroxytryptamine receptor 2B | Homo sapiens | 1466 | Detail |
P20309 |
CHRM3 | Muscarinic acetylcholine receptor M3 | Homo sapiens | 1440 | Detail |
P14867 |
GABRA1 | Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens | 1420 | Detail |
P35368 |
ADRA1B | Alpha-1B adrenergic receptor | Homo sapiens | 1393 | Detail |
P25100 |
ADRA1D | Alpha-1D adrenergic receptor | Homo sapiens | 1327 | Detail |
P31644 |
GABRA5 | Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens | 1276 | Detail |
P18507 |
GABRG2 | Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens | 1275 | Detail |
P22303 |
ACHE | Acetylcholinesterase | Homo sapiens | 1200 | Detail |
P28472 |
GABRB3 | Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens | 1198 | Detail |
P50406 |
HTR6 | 5-hydroxytryptamine receptor 6 | Homo sapiens | 1058 | Detail |
P28221 |
HTR1D | 5-hydroxytryptamine receptor 1D | Homo sapiens | 1019 | Detail |
P34903 |
GABRA3 | Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens | 1007 | Detail |
P28222 |
HTR1B | 5-hydroxytryptamine receptor 1B | Homo sapiens | 999 | Detail |
P47869 |
GABRA2 | Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens | 901 | Detail |
P35367 |
HRH1 | Histamine H1 receptor | Homo sapiens | 872 | Detail |
P17787 |
CHRNB2 | Neuronal acetylcholine receptor subunit beta-2 | Homo sapiens | 781 | Detail |
P32245 |
MC4R | Melanocortin receptor 4 | Homo sapiens | 771 | Detail |
P08913 |
ADRA2A | Alpha-2A adrenergic receptor | Homo sapiens | 761 | Detail |
P43681 |
CHRNA4 | Neuronal acetylcholine receptor subunit alpha-4 | Homo sapiens | 755 | Detail |
Q9Y5N1 |
HRH3 | Histamine H3 receptor | Homo sapiens | 740 | Detail |
P21728 |
DRD1 | D(1A) dopamine receptor | Homo sapiens | 738 | Detail |
P07550 |
ADRB2 | Beta-2 adrenergic receptor | Homo sapiens | 697 | Detail |
P08173 |
CHRM4 | Muscarinic acetylcholine receptor M4 | Homo sapiens | 686 | Detail |
P18825 |
ADRA2C | Alpha-2C adrenergic receptor | Homo sapiens | 685 | Detail |
P17252 |
PRKCA | Protein kinase C alpha type | Homo sapiens | 679 | Detail |
P25103 |
TACR1 | Substance-P receptor | Homo sapiens | 589 | Detail |
P08912 |
CHRM5 | Muscarinic acetylcholine receptor M5 | Homo sapiens | 585 | Detail |
P18089 |
ADRA2B | Alpha-2B adrenergic receptor | Homo sapiens | 566 | Detail |
P41968 |
MC3R | Melanocortin receptor 3 | Homo sapiens | 557 | Detail |
P56373 |
P2RX3 | P2X purinoceptor 3 | Homo sapiens | 550 | Detail |
P08588 |
ADRB1 | Beta-1 adrenergic receptor | Homo sapiens | 541 | Detail |
Q9UBL9 |
P2RX2 | P2X purinoceptor 2 | Homo sapiens | 535 | Detail |
P32297 |
CHRNA3 | Neuronal acetylcholine receptor subunit alpha-3 | Homo sapiens | 506 | Detail |
Q8N1C3 |
GABRG1 | Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens | 485 | Detail |
P05771 |
PRKCB | Protein kinase C beta type | Homo sapiens | 457 | Detail |
P17612 |
PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | Homo sapiens | 453 | Detail |
P47870 |
GABRB2 | Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens | 445 | Detail |
P30926 |
CHRNB4 | Neuronal acetylcholine receptor subunit beta-4 | Homo sapiens | 431 | Detail |
P21452 |
TACR2 | Substance-K receptor | Homo sapiens | 400 | Detail |
Q16445 |
GABRA6 | Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens | 398 | Detail |
P46098 |
HTR3A | 5-hydroxytryptamine receptor 3A | Homo sapiens | 382 | Detail |
P48169 |
GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens | 364 | Detail |
O14764 |
GABRD | Gamma-aminobutyric acid receptor subunit delta | Homo sapiens | 327 | Detail |
Q99928 |
GABRG3 | Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens | 326 | Detail |
P78334 |
GABRE | Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens | 325 | Detail |
O00591 |
GABRP | Gamma-aminobutyric acid receptor subunit pi | Homo sapiens | 325 | Detail |
Q9UN88 |
GABRQ | Gamma-aminobutyric acid receptor subunit theta | Homo sapiens | 325 | Detail |
P36544 |
CHRNA7 | Neuronal acetylcholine receptor subunit alpha-7 | Homo sapiens | 311 | Detail |
P05129 |
PRKCG | Protein kinase C gamma type | Homo sapiens | 311 | Detail |
Q5TC84 |
OGFRL1 | Opioid growth factor receptor-like protein 1 | Homo sapiens | 273 | Detail |
Q12879 |
GRIN2A | Glutamate receptor ionotropic, NMDA 2A | Homo sapiens | 270 | Detail |
Q14957 |
GRIN2C | Glutamate receptor ionotropic, NMDA 2C | Homo sapiens | 243 | Detail |
O60391 |
GRIN3B | Glutamate receptor ionotropic, NMDA 3B | Homo sapiens | 240 | Detail |
O15399 |
GRIN2D | Glutamate receptor ionotropic, NMDA 2D | Homo sapiens | 229 | Detail |
Q8TCU5 |
GRIN3A | Glutamate receptor ionotropic, NMDA 3A | Homo sapiens | 226 | Detail |
P21918 |
DRD5 | D(1B) dopamine receptor | Homo sapiens | 220 | Detail |
O95264 |
HTR3B | 5-hydroxytryptamine receptor 3B | Homo sapiens | 185 | Detail |
Q8WXA8 |
HTR3C | 5-hydroxytryptamine receptor 3C | Homo sapiens | 183 | Detail |
A5X5Y0 |
HTR3E | 5-hydroxytryptamine receptor 3E | Homo sapiens | 183 | Detail |
Q70Z44 |
HTR3D | 5-hydroxytryptamine receptor 3D | Homo sapiens | 182 | Detail |
P29371 |
TACR3 | Neuromedin-K receptor | Homo sapiens | 164 | Detail |
P42261 |
GRIA1 | Glutamate receptor 1 | Homo sapiens | 143 | Detail |
Q14416 |
GRM2 | Metabotropic glutamate receptor 2 | Homo sapiens | 134 | Detail |
P41594 |
GRM5 | Metabotropic glutamate receptor 5 | Homo sapiens | 125 | Detail |
P22694 |
PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Homo sapiens | 121 | Detail |
P25021 |
HRH2 | Histamine H2 receptor | Homo sapiens | 120 | Detail |
P47898 |
HTR5A | 5-hydroxytryptamine receptor 5A | Homo sapiens | 120 | Detail |
Q14832 |
GRM3 | Metabotropic glutamate receptor 3 | Homo sapiens | 115 | Detail |
P22612 |
PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | Homo sapiens | 111 | Detail |
P42262 |
GRIA2 | Glutamate receptor 2 | Homo sapiens | 105 | Detail |
P48058 |
GRIA4 | Glutamate receptor 4 | Homo sapiens | 103 | Detail |
P30939 |
HTR1F | 5-hydroxytryptamine receptor 1F | Homo sapiens | 95 | Detail |
P42263 |
GRIA3 | Glutamate receptor 3 | Homo sapiens | 93 | Detail |
Q13255 |
GRM1 | Metabotropic glutamate receptor 1 | Homo sapiens | 92 | Detail |
Q15825 |
CHRNA6 | Neuronal acetylcholine receptor subunit alpha-6 | Homo sapiens | 92 | Detail |
Q13639 |
HTR4 | 5-hydroxytryptamine receptor 4 | Homo sapiens | 85 | Detail |
P28566 |
HTR1E | 5-hydroxytryptamine receptor 1E | Homo sapiens | 60 | Detail |
Q13519 |
PNOC | Prepronociceptin | Homo sapiens | 58 | Detail |
P39086 |
GRIK1 | Glutamate receptor ionotropic, kainate 1 | Homo sapiens | 44 | Detail |
P43004 |
SLC1A2 | Excitatory amino acid transporter 2 | Homo sapiens | 32 | Detail |
Q16572 |
SLC18A3 | Vesicular acetylcholine transporter | Homo sapiens | 31 | Detail |
Q08828 |
ADCY1 | Adenylate cyclase type 1 | Homo sapiens | 30 | Detail |
P43003 |
SLC1A3 | Excitatory amino acid transporter 1 | Homo sapiens | 28 | Detail |
P40145 |
ADCY8 | Adenylate cyclase type 8 | Homo sapiens | 27 | Detail |
Q9UBS5 |
GABBR1 | Gamma-aminobutyric acid type B receptor subunit 1 | Homo sapiens | 27 | Detail |
P43005 |
SLC1A1 | Excitatory amino acid transporter 3 | Homo sapiens | 26 | Detail |
O75899 |
GABBR2 | Gamma-aminobutyric acid type B receptor subunit 2 | Homo sapiens | 26 | Detail |
O95622 |
ADCY5 | Adenylate cyclase type 5 | Homo sapiens | 23 | Detail |
Q08462 |
ADCY2 | Adenylate cyclase type 2 | Homo sapiens | 21 | Detail |
O60266 |
ADCY3 | Adenylate cyclase type 3 | Homo sapiens | 21 | Detail |
O43306 |
ADCY6 | Adenylate cyclase type 6 | Homo sapiens | 21 | Detail |
P51828 |
ADCY7 | Adenylate cyclase type 7 | Homo sapiens | 21 | Detail |
O60503 |
ADCY9 | Adenylate cyclase type 9 | Homo sapiens | 21 | Detail |
Q8NFM4 |
ADCY4 | Adenylate cyclase type 4 | Homo sapiens | 21 | Detail |
P23415 |
GLRA1 | Glycine receptor subunit alpha-1 | Homo sapiens | 20 | Detail |
Q15391 |
P2RY14 | P2Y purinoceptor 14 | Homo sapiens | 20 | Detail |
P48167 |
GLRB | Glycine receptor subunit beta | Homo sapiens | 19 | Detail |
Q13002 |
GRIK2 | Glutamate receptor ionotropic, kainate 2 | Homo sapiens | 19 | Detail |
P51575 |
P2RX1 | P2X purinoceptor 1 | Homo sapiens | 19 | Detail |
Q13003 |
GRIK3 | Glutamate receptor ionotropic, kainate 3 | Homo sapiens | 16 | Detail |
Q99571 |
P2RX4 | P2X purinoceptor 4 | Homo sapiens | 16 | Detail |
P48067 |
SLC6A9 | Sodium- and chloride-dependent glycine transporter 1 | Homo sapiens | 16 | Detail |
Q16478 |
GRIK5 | Glutamate receptor ionotropic, kainate 5 | Homo sapiens | 15 | Detail |
P20366 |
TAC1 | Protachykinin-1 | Homo sapiens | 13 | Detail |
Q16099 |
GRIK4 | Glutamate receptor ionotropic, kainate 4 | Homo sapiens | 8 | Detail |
P47900 |
P2RY1 | P2Y purinoceptor 1 | Homo sapiens | 8 | Detail |
Q9Y345 |
SLC6A5 | Sodium- and chloride-dependent glycine transporter 2 | Homo sapiens | 7 | Detail |
Q05940 |
SLC18A2 | Synaptic vesicular amine transporter | Homo sapiens | 6 | Detail |
Q9UHF0 |
TAC3 | Tachykinin-3 | Homo sapiens | 6 | Detail |
Q9H244 |
P2RY12 | P2Y purinoceptor 12 | Homo sapiens | 4 | Detail |
A8MPY1 |
GABRR3 | Gamma-aminobutyric acid receptor subunit rho-3 | Homo sapiens | 3 | Detail |
P24046 |
GABRR1 | Gamma-aminobutyric acid receptor subunit rho-1 | Homo sapiens | 3 | Detail |
P04899 |
GNAI2 | Guanine nucleotide-binding protein G(i) subunit alpha-2 | Homo sapiens | 3 | Detail |
O15303 |
GRM6 | Metabotropic glutamate receptor 6 | Homo sapiens | 3 | Detail |
O00222 |
GRM8 | Metabotropic glutamate receptor 8 | Homo sapiens | 3 | Detail |
P29992 |
GNA11 | Guanine nucleotide-binding protein subunit alpha-11 | Homo sapiens | 2 | Detail |
P08754 |
GNAI3 | Guanine nucleotide-binding protein G(i) subunit alpha-3 | Homo sapiens | 2 | Detail |
P50148 |
GNAQ | Guanine nucleotide-binding protein G(q) subunit alpha | Homo sapiens | 2 | Detail |
P62873 |
GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit be | Homo sapiens | 2 | Detail |
Q14833 |
GRM4 | Metabotropic glutamate receptor 4 | Homo sapiens | 2 | Detail |
Q96G91 |
P2RY11 | P2Y purinoceptor 11 | Homo sapiens | 2 | Detail |
P59768 |
GNG2 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit ga | Homo sapiens | 2 | Detail |
Q9NZT2 |
OGFR | Opioid growth factor receptor | Homo sapiens | 1 | Detail |
P28476 |
GABRR2 | Gamma-aminobutyric acid receptor subunit rho-2 | Homo sapiens | 1 | Detail |
Q14831 |
GRM7 | Metabotropic glutamate receptor 7 | Homo sapiens | 1 | Detail |
P01213 |
PDYN | Proenkephalin-B | Homo sapiens | 1 | Detail |
Q9GZV3 |
SLC5A7 | High affinity choline transporter 1 | Homo sapiens | 1 | Detail |
P30531 |
SLC6A1 | Sodium- and chloride-dependent GABA transporter 1 | Homo sapiens | 1 | Detail |
P48066 |
SLC6A11 | Sodium- and chloride-dependent GABA transporter 3 | Homo sapiens | 1 | Detail |
P48065 |
SLC6A12 | Sodium- and chloride-dependent betaine transporter | Homo sapiens | 1 | Detail |
P28329 |
CHAT | Choline O-acetyltransferase | Homo sapiens | 0 | Detail |
Q15077 |
P2RY6 | P2Y purinoceptor 6 | Homo sapiens | 0 | Detail |