Sphingolipid signaling pathway
hsa04071 81 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
P42336 |
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 5616 | Detail |
O00329 |
PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 3772 | Detail |
P30542 |
ADORA1 | Adenosine receptor A1 | Homo sapiens | 3399 | Detail |
P41143 |
OPRD1 | Delta-type opioid receptor | Homo sapiens | 2616 | Detail |
P27986 |
PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | Homo sapiens | 2553 | Detail |
P0DMS8 |
ADORA3 | Adenosine receptor A3 | Homo sapiens | 2190 | Detail |
P04049 |
RAF1 | RAF proto-oncogene serine/threonine-protein kinase | Homo sapiens | 2133 | Detail |
P42338 |
PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 1951 | Detail |
P01116 |
KRAS | GTPase KRas | Homo sapiens | 1811 | Detail |
Q16539 |
MAPK14 | Mitogen-activated protein kinase 14 | Homo sapiens | 1754 | Detail |
O75116 |
ROCK2 | Rho-associated protein kinase 2 | Homo sapiens | 1696 | Detail |
P31749 |
AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens | 1633 | Detail |
Q13464 |
ROCK1 | Rho-associated protein kinase 1 | Homo sapiens | 1614 | Detail |
P04637 |
TP53 | Cellular tumor antigen p53 | Homo sapiens | 1173 | Detail |
P10415 |
BCL2 | Apoptosis regulator Bcl-2 | Homo sapiens | 1065 | Detail |
P01111 |
NRAS | GTPase NRas | Homo sapiens | 923 | Detail |
P28482 |
MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens | 906 | Detail |
P31751 |
AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens | 896 | Detail |
P45983 |
MAPK8 | Mitogen-activated protein kinase 8 | Homo sapiens | 748 | Detail |
P17252 |
PRKCA | Protein kinase C alpha type | Homo sapiens | 679 | Detail |
P45984 |
MAPK9 | Mitogen-activated protein kinase 9 | Homo sapiens | 676 | Detail |
P53779 |
MAPK10 | Mitogen-activated protein kinase 10 | Homo sapiens | 625 | Detail |
P53778 |
MAPK12 | Mitogen-activated protein kinase 12 | Homo sapiens | 606 | Detail |
Q15759 |
MAPK11 | Mitogen-activated protein kinase 11 | Homo sapiens | 594 | Detail |
P07339 |
CTSD | Cathepsin D | Homo sapiens | 551 | Detail |
Q02750 |
MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens | 543 | Detail |
O15264 |
MAPK13 | Mitogen-activated protein kinase 13 | Homo sapiens | 533 | Detail |
O00459 |
PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | Homo sapiens | 485 | Detail |
P05771 |
PRKCB | Protein kinase C beta type | Homo sapiens | 457 | Detail |
Q02156 |
PRKCE | Protein kinase C epsilon type | Homo sapiens | 423 | Detail |
P06241 |
FYN | Tyrosine-protein kinase Fyn | Homo sapiens | 333 | Detail |
Q9Y243 |
AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens | 321 | Detail |
P05129 |
PRKCG | Protein kinase C gamma type | Homo sapiens | 311 | Detail |
O14939 |
PLD2 | Phospholipase D2 | Homo sapiens | 310 | Detail |
P21453 |
S1PR1 | Sphingosine 1-phosphate receptor 1 | Homo sapiens | 309 | Detail |
Q13393 |
PLD1 | Phospholipase D1 | Homo sapiens | 309 | Detail |
Q92569 |
PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | Homo sapiens | 289 | Detail |
P27361 |
MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens | 234 | Detail |
O15530 |
PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | Homo sapiens | 228 | Detail |
Q99500 |
S1PR3 | Sphingosine 1-phosphate receptor 3 | Homo sapiens | 184 | Detail |
Q05513 |
PRKCZ | Protein kinase C zeta type | Homo sapiens | 166 | Detail |
P36507 |
MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | Homo sapiens | 146 | Detail |
P01375 |
TNF | Tumor necrosis factor | Homo sapiens | 144 | Detail |
P19838 |
NFKB1 | Nuclear factor NF-kappa-B p105 subunit | Homo sapiens | 140 | Detail |
Q04206 |
RELA | Transcription factor p65 | Homo sapiens | 134 | Detail |
Q9H228 |
S1PR5 | Sphingosine 1-phosphate receptor 5 | Homo sapiens | 132 | Detail |
O95977 |
S1PR4 | Sphingosine 1-phosphate receptor 4 | Homo sapiens | 120 | Detail |
P29474 |
NOS3 | Nitric oxide synthase 3 | Homo sapiens | 94 | Detail |
O95136 |
S1PR2 | Sphingosine 1-phosphate receptor 2 | Homo sapiens | 90 | Detail |
Q99683 |
MAP3K5 | Mitogen-activated protein kinase kinase kinase 5 | Homo sapiens | 81 | Detail |
Q9NRA0 |
SPHK2 | Sphingosine kinase 2 | Homo sapiens | 60 | Detail |
Q9NYA1 |
SPHK1 | Sphingosine kinase 1 | Homo sapiens | 60 | Detail |
P01042 |
KNG1 | Kininogen-1 | Homo sapiens | 59 | Detail |
O95470 |
SGPL1 | Sphingosine-1-phosphate lyase 1 | Homo sapiens | 50 | Detail |
P55957 |
BID | BH3-interacting domain death agonist | Homo sapiens | 41 | Detail |
P30411 |
BDKRB2 | B2 bradykinin receptor | Homo sapiens | 32 | Detail |
P33527 |
ABCC1 | Multidrug resistance-associated protein 1 | Homo sapiens | 23 | Detail |
P01112 |
HRAS | GTPase HRas | Homo sapiens | 14 | Detail |
O15270 |
SPTLC2 | Serine palmitoyltransferase 2 | Homo sapiens | 6 | Detail |
Q13510 |
ASAH1 | Acid ceramidase | Homo sapiens | 5 | Detail |
P67775 |
PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit al | Homo sapiens | 5 | Detail |
O15269 |
SPTLC1 | Serine palmitoyltransferase 1 | Homo sapiens | 4 | Detail |
Q15172 |
PPP2R5A | Serine/threonine-protein phosphatase 2A 56 kDa regulatory su | Homo sapiens | 4 | Detail |
Q8NHU3 |
SGMS2 | Phosphatidylcholine:ceramide cholinephosphotransferase 2 | Homo sapiens | 3 | Detail |
P04899 |
GNAI2 | Guanine nucleotide-binding protein G(i) subunit alpha-2 | Homo sapiens | 3 | Detail |
Q9NUV7 |
SPTLC3 | Serine palmitoyltransferase 3 | Homo sapiens | 3 | Detail |
P63000 |
RAC1 | Ras-related C3 botulinum toxin substrate 1 | Homo sapiens | 3 | Detail |
P15153 |
RAC2 | Ras-related C3 botulinum toxin substrate 2 | Homo sapiens | 3 | Detail |
O15121 |
DEGS1 | Sphingolipid delta(4)-desaturase DES1 | Homo sapiens | 3 | Detail |
Q86VZ5 |
SGMS1 | Phosphatidylcholine:ceramide cholinephosphotransferase 1 | Homo sapiens | 2 | Detail |
P08754 |
GNAI3 | Guanine nucleotide-binding protein G(i) subunit alpha-3 | Homo sapiens | 2 | Detail |
P50148 |
GNAQ | Guanine nucleotide-binding protein G(q) subunit alpha | Homo sapiens | 2 | Detail |
P63151 |
PPP2R2A | Serine/threonine-protein phosphatase 2A 55 kDa regulatory su | Homo sapiens | 2 | Detail |
P60763 |
RAC3 | Ras-related C3 botulinum toxin substrate 3 | Homo sapiens | 2 | Detail |
P19438 |
TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A | Homo sapiens | 2 | Detail |
Q96G23 |
CERS2 | Ceramide synthase 2 | Homo sapiens | 1 | Detail |
Q5QJU3 |
ACER2 | Alkaline ceramidase 2 | Homo sapiens | 1 | Detail |
Q07812 |
BAX | Apoptosis regulator BAX | Homo sapiens | 1 | Detail |
Q12933 |
TRAF2 | TNF receptor-associated factor 2 | Homo sapiens | 1 | Detail |
P27544 |
CERS1 | Ceramide synthase 1 | Homo sapiens | 0 | Detail |
O60906 |
SMPD2 | Sphingomyelin phosphodiesterase 2 | Homo sapiens | 0 | Detail |