FoxO signaling pathway
hsa04068 85 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
P42336 |
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 5616 | Detail |
P24941 |
CDK2 | Cyclin-dependent kinase 2 | Homo sapiens | 5432 | Detail |
O00329 |
PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 3772 | Detail |
P00533 |
EGFR | Epidermal growth factor receptor | Homo sapiens | 3433 | Detail |
P15056 |
BRAF | Serine/threonine-protein kinase B-raf | Homo sapiens | 2643 | Detail |
P27986 |
PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | Homo sapiens | 2553 | Detail |
P04049 |
RAF1 | RAF proto-oncogene serine/threonine-protein kinase | Homo sapiens | 2133 | Detail |
P42338 |
PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 1951 | Detail |
O43521 |
BCL2L11 | Bcl-2-like protein 11 | Homo sapiens | 1888 | Detail |
P01116 |
KRAS | GTPase KRas | Homo sapiens | 1811 | Detail |
Q16539 |
MAPK14 | Mitogen-activated protein kinase 14 | Homo sapiens | 1754 | Detail |
P24385 |
CCND1 | G1/S-specific cyclin-D1 | Homo sapiens | 1643 | Detail |
P31749 |
AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens | 1633 | Detail |
Q00987 |
MDM2 | E3 ubiquitin-protein ligase Mdm2 | Homo sapiens | 1334 | Detail |
P01111 |
NRAS | GTPase NRas | Homo sapiens | 923 | Detail |
P28482 |
MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens | 906 | Detail |
P31751 |
AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens | 896 | Detail |
P49674 |
CSNK1E | Casein kinase I isoform epsilon | Homo sapiens | 844 | Detail |
Q07889 |
SOS1 | Son of sevenless homolog 1 | Homo sapiens | 766 | Detail |
P45983 |
MAPK8 | Mitogen-activated protein kinase 8 | Homo sapiens | 748 | Detail |
P45984 |
MAPK9 | Mitogen-activated protein kinase 9 | Homo sapiens | 676 | Detail |
P06213 |
INSR | Insulin receptor | Homo sapiens | 656 | Detail |
P53779 |
MAPK10 | Mitogen-activated protein kinase 10 | Homo sapiens | 625 | Detail |
P08069 |
IGF1R | Insulin-like growth factor 1 receptor | Homo sapiens | 611 | Detail |
P53778 |
MAPK12 | Mitogen-activated protein kinase 12 | Homo sapiens | 606 | Detail |
Q15759 |
MAPK11 | Mitogen-activated protein kinase 11 | Homo sapiens | 594 | Detail |
P14635 |
CCNB1 | G2/mitotic-specific cyclin-B1 | Homo sapiens | 552 | Detail |
Q02750 |
MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens | 543 | Detail |
O00444 |
PLK4 | Serine/threonine-protein kinase PLK4 | Homo sapiens | 542 | Detail |
O15264 |
MAPK13 | Mitogen-activated protein kinase 13 | Homo sapiens | 533 | Detail |
O00459 |
PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | Homo sapiens | 485 | Detail |
P41182 |
BCL6 | B-cell lymphoma 6 protein | Homo sapiens | 472 | Detail |
P36897 |
TGFBR1 | TGF-beta receptor type-1 | Homo sapiens | 428 | Detail |
Q92793 |
CREBBP | CREB-binding protein | Homo sapiens | 423 | Detail |
O14920 |
IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | Homo sapiens | 411 | Detail |
P53350 |
PLK1 | Serine/threonine-protein kinase PLK1 | Homo sapiens | 357 | Detail |
Q9Y243 |
AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens | 321 | Detail |
Q09472 |
EP300 | Histone acetyltransferase p300 | Homo sapiens | 320 | Detail |
P21453 |
S1PR1 | Sphingosine 1-phosphate receptor 1 | Homo sapiens | 309 | Detail |
Q92569 |
PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | Homo sapiens | 289 | Detail |
Q13131 |
PRKAA1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | Homo sapiens | 282 | Detail |
Q8WWL7 |
CCNB3 | G2/mitotic-specific cyclin-B3 | Homo sapiens | 242 | Detail |
O95067 |
CCNB2 | G2/mitotic-specific cyclin-B2 | Homo sapiens | 242 | Detail |
P27361 |
MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens | 234 | Detail |
O15530 |
PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | Homo sapiens | 228 | Detail |
Q9H4B4 |
PLK3 | Serine/threonine-protein kinase PLK3 | Homo sapiens | 203 | Detail |
O15111 |
CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | Homo sapiens | 170 | Detail |
Q13315 |
ATM | Serine-protein kinase ATM | Homo sapiens | 170 | Detail |
P36507 |
MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | Homo sapiens | 146 | Detail |
P37173 |
TGFBR2 | TGF-beta receptor type-2 | Homo sapiens | 144 | Detail |
O95977 |
S1PR4 | Sphingosine 1-phosphate receptor 4 | Homo sapiens | 120 | Detail |
Q9NYY3 |
PLK2 | Serine/threonine-protein kinase PLK2 | Homo sapiens | 110 | Detail |
Q9HBY8 |
SGK2 | Serine/threonine-protein kinase Sgk2 | Homo sapiens | 99 | Detail |
Q13043 |
STK4 | Serine/threonine-protein kinase 4 | Homo sapiens | 94 | Detail |
Q13255 |
GRM1 | Metabotropic glutamate receptor 1 | Homo sapiens | 92 | Detail |
Q99873 |
PRMT1 | Protein arginine N-methyltransferase 1 | Homo sapiens | 86 | Detail |
P54619 |
PRKAG1 | 5'-AMP-activated protein kinase subunit gamma-1 | Homo sapiens | 83 | Detail |
Q96EB6 |
SIRT1 | NAD-dependent protein deacetylase sirtuin-1 | Homo sapiens | 78 | Detail |
P54646 |
PRKAA2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | Homo sapiens | 75 | Detail |
P30279 |
CCND2 | G1/S-specific cyclin-D2 | Homo sapiens | 71 | Detail |
Q9Y478 |
PRKAB1 | 5'-AMP-activated protein kinase subunit beta-1 | Homo sapiens | 65 | Detail |
Q9UBE8 |
NLK | Serine/threonine-protein kinase NLK | Homo sapiens | 54 | Detail |
P40763 |
STAT3 | Signal transducer and activator of transcription 3 | Homo sapiens | 49 | Detail |
O43741 |
PRKAB2 | 5'-AMP-activated protein kinase subunit beta-2 | Homo sapiens | 45 | Detail |
Q9UGJ0 |
PRKAG2 | 5'-AMP-activated protein kinase subunit gamma-2 | Homo sapiens | 44 | Detail |
P14672 |
SLC2A4 | Solute carrier family 2, facilitated glucose transporter mem | Homo sapiens | 40 | Detail |
P10398 |
ARAF | Serine/threonine-protein kinase A-Raf | Homo sapiens | 37 | Detail |
O00141 |
SGK1 | Serine/threonine-protein kinase Sgk1 | Homo sapiens | 34 | Detail |
Q9UGI9 |
PRKAG3 | 5'-AMP-activated protein kinase subunit gamma-3 | Homo sapiens | 30 | Detail |
P05231 |
IL6 | Interleukin-6 | Homo sapiens | 17 | Detail |
Q15831 |
STK11 | Serine/threonine-protein kinase STK11 | Homo sapiens | 17 | Detail |
Q96BR1 |
SGK3 | Serine/threonine-protein kinase Sgk3 | Homo sapiens | 16 | Detail |
P01112 |
HRAS | GTPase HRas | Homo sapiens | 14 | Detail |
P84022 |
SMAD3 | SMAD family member 3 | Homo sapiens | 11 | Detail |
Q93009 |
USP7 | Ubiquitin carboxyl-terminal hydrolase 7 | Homo sapiens | 11 | Detail |
P01137 |
TGFB1 | Transforming growth factor beta-1 proprotein | Homo sapiens | 8 | Detail |
Q13309 |
SKP2 | S-phase kinase-associated protein 2 | Homo sapiens | 7 | Detail |
P62993 |
GRB2 | Growth factor receptor-bound protein 2 | Homo sapiens | 4 | Detail |
P35568 |
IRS1 | Insulin receptor substrate 1 | Homo sapiens | 2 | Detail |
Q16822 |
PCK2 | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial | Homo sapiens | 2 | Detail |
P61812 |
TGFB2 | Transforming growth factor beta-2 proprotein | Homo sapiens | 2 | Detail |
Q8WTS6 |
SETD7 | Histone-lysine N-methyltransferase SETD7 | Homo sapiens | 2 | Detail |
P38936 |
CDKN1A | Cyclin-dependent kinase inhibitor 1 | Homo sapiens | 1 | Detail |
P60520 |
GABARAPL2 | Gamma-aminobutyric acid receptor-associated protein-like 2 | Homo sapiens | 1 | Detail |
P04040 |
CAT | Catalase | Homo sapiens | 1 | Detail |