HIF-1 signaling pathway

hsa04066 80 targets in this pathway

UniProt AC Gene Protein Name Organism Multi-Target Molecules
P42336 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub Homo sapiens 5616 Detail
O00329 PIK3CD Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub Homo sapiens 3772 Detail
P00533 EGFR Epidermal growth factor receptor Homo sapiens 3433 Detail
P27986 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha Homo sapiens 2553 Detail
P42345 MTOR Serine/threonine-protein kinase mTOR Homo sapiens 2517 Detail
P04626 ERBB2 Receptor tyrosine-protein kinase erbB-2 Homo sapiens 2123 Detail
P42338 PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub Homo sapiens 1951 Detail
P31749 AKT1 RAC-alpha serine/threonine-protein kinase Homo sapiens 1633 Detail
P17948 FLT1 Vascular endothelial growth factor receptor 1 Homo sapiens 1237 Detail
P23443 RPS6KB1 Ribosomal protein S6 kinase beta-1 Homo sapiens 1180 Detail
P10415 BCL2 Apoptosis regulator Bcl-2 Homo sapiens 1065 Detail
P28482 MAPK1 Mitogen-activated protein kinase 1 Homo sapiens 906 Detail
P31751 AKT2 RAC-beta serine/threonine-protein kinase Homo sapiens 896 Detail
P17252 PRKCA Protein kinase C alpha type Homo sapiens 679 Detail
P06213 INSR Insulin receptor Homo sapiens 656 Detail
P08069 IGF1R Insulin-like growth factor 1 receptor Homo sapiens 611 Detail
Q9HBH9 MKNK2 MAP kinase-interacting serine/threonine-protein kinase 2 Homo sapiens 608 Detail
Q02750 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens 543 Detail
Q15118 PDK1 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozym Homo sapiens 524 Detail
Q02763 TEK Angiopoietin-1 receptor Homo sapiens 507 Detail
O00459 PIK3R2 Phosphatidylinositol 3-kinase regulatory subunit beta Homo sapiens 485 Detail
P05771 PRKCB Protein kinase C beta type Homo sapiens 457 Detail
Q9BUB5 MKNK1 MAP kinase-interacting serine/threonine-protein kinase 1 Homo sapiens 445 Detail
Q92793 CREBBP CREB-binding protein Homo sapiens 423 Detail
Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein Homo sapiens 358 Detail
Q9Y243 AKT3 RAC-gamma serine/threonine-protein kinase Homo sapiens 321 Detail
Q09472 EP300 Histone acetyltransferase p300 Homo sapiens 320 Detail
P05129 PRKCG Protein kinase C gamma type Homo sapiens 311 Detail
Q92569 PIK3R3 Phosphatidylinositol 3-kinase regulatory subunit gamma Homo sapiens 289 Detail
P27361 MAPK3 Mitogen-activated protein kinase 3 Homo sapiens 234 Detail
P11166 SLC2A1 Solute carrier family 2, facilitated glucose transporter mem Homo sapiens 189 Detail
P40337 VHL von Hippel-Lindau disease tumor suppressor Homo sapiens 158 Detail
P15260 IFNGR1 Interferon gamma receptor 1 Homo sapiens 150 Detail
P35228 NOS2 Nitric oxide synthase, inducible Homo sapiens 150 Detail
Q13557 CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit Homo sapiens 150 Detail
P36507 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 Homo sapiens 146 Detail
P19838 NFKB1 Nuclear factor NF-kappa-B p105 subunit Homo sapiens 140 Detail
Q04206 RELA Transcription factor p65 Homo sapiens 134 Detail
Q9GZT9 EGLN1 Egl nine homolog 1 Homo sapiens 133 Detail
P00338 LDHA L-lactate dehydrogenase A chain Homo sapiens 125 Detail
Q13555 CAMK2G Calcium/calmodulin-dependent protein kinase type II subunit Homo sapiens 123 Detail
Q96KS0 EGLN2 Prolyl hydroxylase EGLN2 Homo sapiens 120 Detail
P07195 LDHB L-lactate dehydrogenase B chain Homo sapiens 119 Detail
Q9H6Z9 EGLN3 Prolyl hydroxylase EGLN3 Homo sapiens 117 Detail
Q99814 EPAS1 Endothelial PAS domain-containing protein 1 Homo sapiens 107 Detail
P29474 NOS3 Nitric oxide synthase 3 Homo sapiens 94 Detail
Q15369 ELOC Elongin-C Homo sapiens 86 Detail
Q15370 ELOB Elongin-B Homo sapiens 85 Detail
Q16665 HIF1A Hypoxia-inducible factor 1-alpha Homo sapiens 81 Detail
Q9UQM7 CAMK2A Calcium/calmodulin-dependent protein kinase type II subunit Homo sapiens 75 Detail
Q13554 CAMK2B Calcium/calmodulin-dependent protein kinase type II subunit Homo sapiens 68 Detail
P40763 STAT3 Signal transducer and activator of transcription 3 Homo sapiens 49 Detail
P06730 EIF4E Eukaryotic translation initiation factor 4E Homo sapiens 46 Detail
P15692 VEGFA Vascular endothelial growth factor A, long form Homo sapiens 44 Detail
Q13617 CUL2 Cullin-2 Homo sapiens 42 Detail
P27540 ARNT Aryl hydrocarbon receptor nuclear translocator Homo sapiens 30 Detail
P05231 IL6 Interleukin-6 Homo sapiens 17 Detail
Q16875 PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 Homo sapiens 15 Detail
P62753 RPS6 Small ribosomal subunit protein eS6 Homo sapiens 13 Detail
Q9UBS0 RPS6KB2 Ribosomal protein S6 kinase beta-2 Homo sapiens 13 Detail
P19367 HK1 Hexokinase-1 Homo sapiens 12 Detail
P52789 HK2 Hexokinase-2 Homo sapiens 11 Detail
P01160 NPPA Natriuretic peptides A Homo sapiens 11 Detail
P00558 PGK1 Phosphoglycerate kinase 1 Homo sapiens 10 Detail
O00206 TLR4 Toll-like receptor 4 Homo sapiens 9 Detail
P07205 PGK2 Phosphoglycerate kinase 2 Homo sapiens 8 Detail
P04839 CYBB NADPH oxidase 2 Homo sapiens 6 Detail
P06733 ENO1 Alpha-enolase Homo sapiens 3 Detail
V9HWB9 HEL-S-133P L-lactate dehydrogenase Homo sapiens 3 Detail
P09104 ENO2 Gamma-enolase Homo sapiens 2 Detail
P08559 PDHA1 Pyruvate dehydrogenase E1 component subunit alpha, somatic f Homo sapiens 2 Detail
Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type Homo sapiens 2 Detail
P19174 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase ga Homo sapiens 2 Detail
P16885 PLCG2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase ga Homo sapiens 2 Detail
P38936 CDKN1A Cyclin-dependent kinase inhibitor 1 Homo sapiens 1 Detail
P04075 ALDOA Fructose-bisphosphate aldolase A Homo sapiens 1 Detail
P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 1 Detail
P09601 HMOX1 Heme oxygenase 1 Homo sapiens 1 Detail
P17858 PFKL ATP-dependent 6-phosphofructokinase, liver type Homo sapiens 1 Detail
P02786 TFRC Transferrin receptor protein 1 Homo sapiens 1 Detail