cGMP-PKG signaling pathway
hsa04022 99 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
P30542 |
ADORA1 | Adenosine receptor A1 | Homo sapiens | 3399 | Detail |
P41143 |
OPRD1 | Delta-type opioid receptor | Homo sapiens | 2616 | Detail |
P48736 |
PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 2398 | Detail |
P0DMS8 |
ADORA3 | Adenosine receptor A3 | Homo sapiens | 2190 | Detail |
P04049 |
RAF1 | RAF proto-oncogene serine/threonine-protein kinase | Homo sapiens | 2133 | Detail |
P35348 |
ADRA1A | Alpha-1A adrenergic receptor | Homo sapiens | 1709 | Detail |
O75116 |
ROCK2 | Rho-associated protein kinase 2 | Homo sapiens | 1696 | Detail |
P31749 |
AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens | 1633 | Detail |
Q13464 |
ROCK1 | Rho-associated protein kinase 1 | Homo sapiens | 1614 | Detail |
P35368 |
ADRA1B | Alpha-1B adrenergic receptor | Homo sapiens | 1393 | Detail |
P25100 |
ADRA1D | Alpha-1D adrenergic receptor | Homo sapiens | 1327 | Detail |
Q14432 |
PDE3A | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A | Homo sapiens | 995 | Detail |
Q13370 |
PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B | Homo sapiens | 936 | Detail |
P28482 |
MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens | 906 | Detail |
P31751 |
AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens | 896 | Detail |
P08913 |
ADRA2A | Alpha-2A adrenergic receptor | Homo sapiens | 761 | Detail |
P07550 |
ADRB2 | Beta-2 adrenergic receptor | Homo sapiens | 697 | Detail |
P30556 |
AGTR1 | Type-1 angiotensin II receptor | Homo sapiens | 696 | Detail |
P18825 |
ADRA2C | Alpha-2C adrenergic receptor | Homo sapiens | 685 | Detail |
P06213 |
INSR | Insulin receptor | Homo sapiens | 656 | Detail |
P18089 |
ADRA2B | Alpha-2B adrenergic receptor | Homo sapiens | 566 | Detail |
Q02750 |
MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens | 543 | Detail |
P08588 |
ADRB1 | Beta-1 adrenergic receptor | Homo sapiens | 541 | Detail |
P25101 |
EDNRA | Endothelin-1 receptor | Homo sapiens | 535 | Detail |
P24530 |
EDNRB | Endothelin receptor type B | Homo sapiens | 507 | Detail |
Q02156 |
PRKCE | Protein kinase C epsilon type | Homo sapiens | 423 | Detail |
Q9Y243 |
AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens | 321 | Detail |
Q8WYR1 |
PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | Homo sapiens | 297 | Detail |
O00408 |
PDE2A | cGMP-dependent 3',5'-cyclic phosphodiesterase | Homo sapiens | 293 | Detail |
P13945 |
ADRB3 | Beta-3 adrenergic receptor | Homo sapiens | 254 | Detail |
P27361 |
MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens | 234 | Detail |
Q02108 |
GUCY1A1 | Guanylate cyclase soluble subunit alpha-1 | Homo sapiens | 231 | Detail |
Q02153 |
GUCY1B1 | Guanylate cyclase soluble subunit beta-1 | Homo sapiens | 231 | Detail |
O76074 |
PDE5A | cGMP-specific 3',5'-cyclic phosphodiesterase | Homo sapiens | 188 | Detail |
P30405 |
PPIF | Peptidyl-prolyl cis-trans isomerase F, mitochondrial | Homo sapiens | 172 | Detail |
Q13936 |
CACNA1C | Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens | 147 | Detail |
P36507 |
MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | Homo sapiens | 146 | Detail |
P05023 |
ATP1A1 | Sodium/potassium-transporting ATPase subunit alpha-1 | Homo sapiens | 135 | Detail |
Q13976 |
PRKG1 | cGMP-dependent protein kinase 1 | Homo sapiens | 135 | Detail |
P50993 |
ATP1A2 | Sodium/potassium-transporting ATPase subunit alpha-2 | Homo sapiens | 134 | Detail |
P05026 |
ATP1B1 | Sodium/potassium-transporting ATPase subunit beta-1 | Homo sapiens | 122 | Detail |
P54709 |
ATP1B3 | Sodium/potassium-transporting ATPase subunit beta-3 | Homo sapiens | 120 | Detail |
P14415 |
ATP1B2 | Sodium/potassium-transporting ATPase subunit beta-2 | Homo sapiens | 119 | Detail |
Q01668 |
CACNA1D | Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens | 117 | Detail |
O60840 |
CACNA1F | Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens | 117 | Detail |
Q13698 |
CACNA1S | Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens | 117 | Detail |
P13637 |
ATP1A3 | Sodium/potassium-transporting ATPase subunit alpha-3 | Homo sapiens | 100 | Detail |
Q13733 |
ATP1A4 | Sodium/potassium-transporting ATPase subunit alpha-4 | Homo sapiens | 100 | Detail |
P54710 |
FXYD2 | Sodium/potassium-transporting ATPase subunit gamma | Homo sapiens | 100 | Detail |
P29474 |
NOS3 | Nitric oxide synthase 3 | Homo sapiens | 94 | Detail |
Q13237 |
PRKG2 | cGMP-dependent protein kinase 2 | Homo sapiens | 91 | Detail |
Q14814 |
MEF2D | Myocyte-specific enhancer factor 2D | Homo sapiens | 66 | Detail |
P01042 |
KNG1 | Kininogen-1 | Homo sapiens | 59 | Detail |
Q9Y210 |
TRPC6 | Short transient receptor potential channel 6 | Homo sapiens | 48 | Detail |
Q86YV6 |
MYLK4 | Myosin light chain kinase family member 4 | Homo sapiens | 43 | Detail |
Q15746 |
MYLK | Myosin light chain kinase, smooth muscle | Homo sapiens | 42 | Detail |
P30411 |
BDKRB2 | B2 bradykinin receptor | Homo sapiens | 32 | Detail |
Q08828 |
ADCY1 | Adenylate cyclase type 1 | Homo sapiens | 30 | Detail |
P40145 |
ADCY8 | Adenylate cyclase type 8 | Homo sapiens | 27 | Detail |
P48454 |
PPP3CC | Serine/threonine-protein phosphatase 2B catalytic subunit ga | Homo sapiens | 27 | Detail |
Q92934 |
BAD | Bcl2-associated agonist of cell death | Homo sapiens | 27 | Detail |
Q32MK0 |
MYLK3 | Myosin light chain kinase 3 | Homo sapiens | 27 | Detail |
O95622 |
ADCY5 | Adenylate cyclase type 5 | Homo sapiens | 23 | Detail |
Q9H1R3 |
MYLK2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Homo sapiens | 22 | Detail |
Q08462 |
ADCY2 | Adenylate cyclase type 2 | Homo sapiens | 21 | Detail |
O60266 |
ADCY3 | Adenylate cyclase type 3 | Homo sapiens | 21 | Detail |
O43306 |
ADCY6 | Adenylate cyclase type 6 | Homo sapiens | 21 | Detail |
P51828 |
ADCY7 | Adenylate cyclase type 7 | Homo sapiens | 21 | Detail |
O60503 |
ADCY9 | Adenylate cyclase type 9 | Homo sapiens | 21 | Detail |
Q8NFM4 |
ADCY4 | Adenylate cyclase type 4 | Homo sapiens | 21 | Detail |
P16066 |
NPR1 | Atrial natriuretic peptide receptor 1 | Homo sapiens | 19 | Detail |
Q15842 |
KCNJ8 | ATP-sensitive inward rectifier potassium channel 8 | Homo sapiens | 11 | Detail |
P01160 |
NPPA | Natriuretic peptides A | Homo sapiens | 11 | Detail |
P0DP23 |
CALM1 | Calmodulin-1 | Homo sapiens | 8 | Detail |
P16615 |
ATP2A2 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | Homo sapiens | 5 | Detail |
P20594 |
NPR2 | Atrial natriuretic peptide receptor 2 | Homo sapiens | 5 | Detail |
P36873 |
PPP1CC | Serine/threonine-protein phosphatase PP1-gamma catalytic sub | Homo sapiens | 5 | Detail |
Q14643 |
ITPR1 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 | Homo sapiens | 4 | Detail |
Q14573 |
ITPR3 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 | Homo sapiens | 4 | Detail |
Q08209 |
PPP3CA | Protein phosphatase 3 catalytic subunit alpha | Homo sapiens | 4 | Detail |
P04899 |
GNAI2 | Guanine nucleotide-binding protein G(i) subunit alpha-2 | Homo sapiens | 3 | Detail |
P12236 |
SLC25A6 | ADP/ATP translocase 3 | Homo sapiens | 3 | Detail |
Q14571 |
ITPR2 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 | Homo sapiens | 3 | Detail |
P29992 |
GNA11 | Guanine nucleotide-binding protein subunit alpha-11 | Homo sapiens | 2 | Detail |
P08754 |
GNAI3 | Guanine nucleotide-binding protein G(i) subunit alpha-3 | Homo sapiens | 2 | Detail |
P50148 |
GNAQ | Guanine nucleotide-binding protein G(q) subunit alpha | Homo sapiens | 2 | Detail |
P05141 |
SLC25A5 | ADP/ATP translocase 2 | Homo sapiens | 2 | Detail |
P35568 |
IRS1 | Insulin receptor substrate 1 | Homo sapiens | 2 | Detail |
Q12791 |
KCNMA1 | Calcium-activated potassium channel subunit alpha-1 | Homo sapiens | 2 | Detail |
O14983 |
ATP2A1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Homo sapiens | 2 | Detail |
Q93084 |
ATP2A3 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | Homo sapiens | 2 | Detail |
P62136 |
PPP1CA | Serine/threonine-protein phosphatase PP1-alpha catalytic sub | Homo sapiens | 2 | Detail |
P21796 |
VDAC1 | Non-selective voltage-gated ion channel VDAC1 | Homo sapiens | 2 | Detail |
Q9Y277 |
VDAC3 | Non-selective voltage-gated ion channel VDAC3 | Homo sapiens | 2 | Detail |
Q86W47 |
KCNMB4 | Calcium-activated potassium channel subunit beta-4 | Homo sapiens | 1 | Detail |
P78347 |
GTF2I | General transcription factor II-I | Homo sapiens | 1 | Detail |
Q16558 |
KCNMB1 | Calcium-activated potassium channel subunit beta-1 | Homo sapiens | 1 | Detail |
P50552 |
VASP | Vasodilator-stimulated phosphoprotein | Homo sapiens | 1 | Detail |
P45880 |
VDAC2 | Non-selective voltage-gated ion channel VDAC2 | Homo sapiens | 1 | Detail |