ErbB signaling pathway
hsa04012 65 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
P42336 |
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 5616 | Detail |
O00329 |
PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 3772 | Detail |
P00533 |
EGFR | Epidermal growth factor receptor | Homo sapiens | 3433 | Detail |
P15056 |
BRAF | Serine/threonine-protein kinase B-raf | Homo sapiens | 2643 | Detail |
P27986 |
PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | Homo sapiens | 2553 | Detail |
P42345 |
MTOR | Serine/threonine-protein kinase mTOR | Homo sapiens | 2517 | Detail |
P49841 |
GSK3B | Glycogen synthase kinase-3 beta | Homo sapiens | 2206 | Detail |
P04049 |
RAF1 | RAF proto-oncogene serine/threonine-protein kinase | Homo sapiens | 2133 | Detail |
P04626 |
ERBB2 | Receptor tyrosine-protein kinase erbB-2 | Homo sapiens | 2123 | Detail |
P12931 |
SRC | Proto-oncogene tyrosine-protein kinase Src | Homo sapiens | 1978 | Detail |
P42338 |
PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 1951 | Detail |
P01116 |
KRAS | GTPase KRas | Homo sapiens | 1811 | Detail |
P31749 |
AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens | 1633 | Detail |
P00519 |
ABL1 | Tyrosine-protein kinase ABL1 | Homo sapiens | 1419 | Detail |
P23443 |
RPS6KB1 | Ribosomal protein S6 kinase beta-1 | Homo sapiens | 1180 | Detail |
P01111 |
NRAS | GTPase NRas | Homo sapiens | 923 | Detail |
P28482 |
MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens | 906 | Detail |
P31751 |
AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens | 896 | Detail |
Q07889 |
SOS1 | Son of sevenless homolog 1 | Homo sapiens | 766 | Detail |
P45983 |
MAPK8 | Mitogen-activated protein kinase 8 | Homo sapiens | 748 | Detail |
Q13191 |
CBLB | E3 ubiquitin-protein ligase CBL-B | Homo sapiens | 746 | Detail |
P17252 |
PRKCA | Protein kinase C alpha type | Homo sapiens | 679 | Detail |
P45984 |
MAPK9 | Mitogen-activated protein kinase 9 | Homo sapiens | 676 | Detail |
P53779 |
MAPK10 | Mitogen-activated protein kinase 10 | Homo sapiens | 625 | Detail |
Q02750 |
MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens | 543 | Detail |
O00459 |
PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | Homo sapiens | 485 | Detail |
P05771 |
PRKCB | Protein kinase C beta type | Homo sapiens | 457 | Detail |
Q13541 |
EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein | Homo sapiens | 358 | Detail |
Q15303 |
ERBB4 | Receptor tyrosine-protein kinase erbB-4 | Homo sapiens | 336 | Detail |
Q05397 |
PTK2 | Focal adhesion kinase 1 | Homo sapiens | 325 | Detail |
Q9Y243 |
AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens | 321 | Detail |
P05129 |
PRKCG | Protein kinase C gamma type | Homo sapiens | 311 | Detail |
Q92569 |
PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | Homo sapiens | 289 | Detail |
P27361 |
MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens | 234 | Detail |
P42684 |
ABL2 | Tyrosine-protein kinase ABL2 | Homo sapiens | 202 | Detail |
O96013 |
PAK4 | Serine/threonine-protein kinase PAK 4 | Homo sapiens | 189 | Detail |
Q13557 |
CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 150 | Detail |
P36507 |
MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | Homo sapiens | 146 | Detail |
Q13555 |
CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 123 | Detail |
P21860 |
ERBB3 | Receptor tyrosine-protein kinase erbB-3 | Homo sapiens | 109 | Detail |
Q13153 |
PAK1 | Serine/threonine-protein kinase PAK 1 | Homo sapiens | 107 | Detail |
Q9UQM7 |
CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 75 | Detail |
P05412 |
JUN | Transcription factor Jun | Homo sapiens | 69 | Detail |
Q13554 |
CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit | Homo sapiens | 68 | Detail |
Q13177 |
PAK2 | Serine/threonine-protein kinase PAK 2 | Homo sapiens | 47 | Detail |
P10398 |
ARAF | Serine/threonine-protein kinase A-Raf | Homo sapiens | 37 | Detail |
O75914 |
PAK3 | Serine/threonine-protein kinase PAK 3 | Homo sapiens | 35 | Detail |
P45985 |
MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | Homo sapiens | 31 | Detail |
Q92934 |
BAD | Bcl2-associated agonist of cell death | Homo sapiens | 27 | Detail |
Q9P286 |
PAK5 | Serine/threonine-protein kinase PAK 5 | Homo sapiens | 23 | Detail |
Q9NQU5 |
PAK6 | Serine/threonine-protein kinase PAK 6 | Homo sapiens | 21 | Detail |
P01106 |
MYC | Myc proto-oncogene protein | Homo sapiens | 19 | Detail |
P22681 |
CBL | E3 ubiquitin-protein ligase CBL | Homo sapiens | 16 | Detail |
O14733 |
MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 | Homo sapiens | 15 | Detail |
P01112 |
HRAS | GTPase HRas | Homo sapiens | 14 | Detail |
Q9UBS0 |
RPS6KB2 | Ribosomal protein S6 kinase beta-2 | Homo sapiens | 13 | Detail |
P42229 |
STAT5A | Signal transducer and activator of transcription 5A | Homo sapiens | 11 | Detail |
P15514 |
AREG | Amphiregulin | Homo sapiens | 7 | Detail |
P51692 |
STAT5B | Signal transducer and activator of transcription 5B | Homo sapiens | 5 | Detail |
P62993 |
GRB2 | Growth factor receptor-bound protein 2 | Homo sapiens | 4 | Detail |
Q13480 |
GAB1 | GRB2-associated-binding protein 1 | Homo sapiens | 2 | Detail |
P19174 |
PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase ga | Homo sapiens | 2 | Detail |
P16885 |
PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase ga | Homo sapiens | 2 | Detail |
P38936 |
CDKN1A | Cyclin-dependent kinase inhibitor 1 | Homo sapiens | 1 | Detail |
P46109 |
CRKL | Crk-like protein | Homo sapiens | 1 | Detail |