MAPK signaling pathway
hsa04010 187 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
P35968 |
KDR | Vascular endothelial growth factor receptor 2 | Homo sapiens | 5667 | Detail |
P00533 |
EGFR | Epidermal growth factor receptor | Homo sapiens | 3433 | Detail |
P11362 |
FGFR1 | Fibroblast growth factor receptor 1 | Homo sapiens | 3320 | Detail |
P22607 |
FGFR3 | Fibroblast growth factor receptor 3 | Homo sapiens | 2742 | Detail |
P15056 |
BRAF | Serine/threonine-protein kinase B-raf | Homo sapiens | 2643 | Detail |
P36888 |
FLT3 | Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens | 2188 | Detail |
P04049 |
RAF1 | RAF proto-oncogene serine/threonine-protein kinase | Homo sapiens | 2133 | Detail |
P21802 |
FGFR2 | Fibroblast growth factor receptor 2 | Homo sapiens | 2130 | Detail |
P04626 |
ERBB2 | Receptor tyrosine-protein kinase erbB-2 | Homo sapiens | 2123 | Detail |
P01116 |
KRAS | GTPase KRas | Homo sapiens | 1811 | Detail |
Q16539 |
MAPK14 | Mitogen-activated protein kinase 14 | Homo sapiens | 1754 | Detail |
P31749 |
AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens | 1633 | Detail |
P09619 |
PDGFRB | Platelet-derived growth factor receptor beta | Homo sapiens | 1527 | Detail |
P22455 |
FGFR4 | Fibroblast growth factor receptor 4 | Homo sapiens | 1506 | Detail |
P17948 |
FLT1 | Vascular endothelial growth factor receptor 1 | Homo sapiens | 1237 | Detail |
P04637 |
TP53 | Cellular tumor antigen p53 | Homo sapiens | 1173 | Detail |
P10721 |
KIT | Mast/stem cell growth factor receptor Kit | Homo sapiens | 1134 | Detail |
P04629 |
NTRK1 | High affinity nerve growth factor receptor | Homo sapiens | 1127 | Detail |
P08581 |
MET | Hepatocyte growth factor receptor | Homo sapiens | 1125 | Detail |
P01111 |
NRAS | GTPase NRas | Homo sapiens | 923 | Detail |
P28482 |
MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens | 906 | Detail |
P07333 |
CSF1R | Macrophage colony-stimulating factor 1 receptor | Homo sapiens | 896 | Detail |
P31751 |
AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens | 896 | Detail |
P16234 |
PDGFRA | Platelet-derived growth factor receptor alpha | Homo sapiens | 860 | Detail |
Q07889 |
SOS1 | Son of sevenless homolog 1 | Homo sapiens | 766 | Detail |
P45983 |
MAPK8 | Mitogen-activated protein kinase 8 | Homo sapiens | 748 | Detail |
P17252 |
PRKCA | Protein kinase C alpha type | Homo sapiens | 679 | Detail |
P45984 |
MAPK9 | Mitogen-activated protein kinase 9 | Homo sapiens | 676 | Detail |
P06213 |
INSR | Insulin receptor | Homo sapiens | 656 | Detail |
P07949 |
RET | Proto-oncogene tyrosine-protein kinase receptor Ret | Homo sapiens | 656 | Detail |
P35916 |
FLT4 | Vascular endothelial growth factor receptor 3 | Homo sapiens | 636 | Detail |
P53779 |
MAPK10 | Mitogen-activated protein kinase 10 | Homo sapiens | 625 | Detail |
P08069 |
IGF1R | Insulin-like growth factor 1 receptor | Homo sapiens | 611 | Detail |
Q9HBH9 |
MKNK2 | MAP kinase-interacting serine/threonine-protein kinase 2 | Homo sapiens | 608 | Detail |
P53778 |
MAPK12 | Mitogen-activated protein kinase 12 | Homo sapiens | 606 | Detail |
Q15759 |
MAPK11 | Mitogen-activated protein kinase 11 | Homo sapiens | 594 | Detail |
Q02750 |
MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens | 543 | Detail |
P29317 |
EPHA2 | Ephrin type-A receptor 2 | Homo sapiens | 540 | Detail |
Q16620 |
NTRK2 | BDNF/NT-3 growth factors receptor | Homo sapiens | 538 | Detail |
O15264 |
MAPK13 | Mitogen-activated protein kinase 13 | Homo sapiens | 533 | Detail |
Q02763 |
TEK | Angiopoietin-1 receptor | Homo sapiens | 507 | Detail |
O95819 |
MAP4K4 | Mitogen-activated protein kinase kinase kinase kinase 4 | Homo sapiens | 496 | Detail |
P05771 |
PRKCB | Protein kinase C beta type | Homo sapiens | 457 | Detail |
P17612 |
PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | Homo sapiens | 453 | Detail |
Q9BUB5 |
MKNK1 | MAP kinase-interacting serine/threonine-protein kinase 1 | Homo sapiens | 445 | Detail |
P42574 |
CASP3 | Caspase-3 | Homo sapiens | 444 | Detail |
Q9NWZ3 |
IRAK4 | Interleukin-1 receptor-associated kinase 4 | Homo sapiens | 431 | Detail |
P36897 |
TGFBR1 | TGF-beta receptor type-1 | Homo sapiens | 428 | Detail |
O14920 |
IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | Homo sapiens | 411 | Detail |
Q15303 |
ERBB4 | Receptor tyrosine-protein kinase erbB-4 | Homo sapiens | 336 | Detail |
Q12851 |
MAP4K2 | Mitogen-activated protein kinase kinase kinase kinase 2 | Homo sapiens | 326 | Detail |
P51812 |
RPS6KA3 | Ribosomal protein S6 kinase alpha-3 | Homo sapiens | 322 | Detail |
Q9Y243 |
AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens | 321 | Detail |
P51617 |
IRAK1 | Interleukin-1 receptor-associated kinase 1 | Homo sapiens | 312 | Detail |
P05129 |
PRKCG | Protein kinase C gamma type | Homo sapiens | 311 | Detail |
Q13188 |
STK3 | Serine/threonine-protein kinase 3 | Homo sapiens | 285 | Detail |
O95180 |
CACNA1H | Voltage-dependent T-type calcium channel subunit alpha-1H | Homo sapiens | 265 | Detail |
O43497 |
CACNA1G | Voltage-dependent T-type calcium channel subunit alpha-1G | Homo sapiens | 265 | Detail |
P27361 |
MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens | 234 | Detail |
P54289 |
CACNA2D1 | Voltage-dependent calcium channel subunit alpha-2/delta-1 | Homo sapiens | 234 | Detail |
O43283 |
MAP3K13 | Mitogen-activated protein kinase kinase kinase 13 | Homo sapiens | 234 | Detail |
Q92918 |
MAP4K1 | Mitogen-activated protein kinase kinase kinase kinase 1 | Homo sapiens | 225 | Detail |
Q99558 |
MAP3K14 | Mitogen-activated protein kinase kinase kinase 14 | Homo sapiens | 224 | Detail |
Q9P0X4 |
CACNA1I | Voltage-dependent T-type calcium channel subunit alpha-1I | Homo sapiens | 214 | Detail |
Q13233 |
MAP3K1 | Mitogen-activated protein kinase kinase kinase 1 | Homo sapiens | 188 | Detail |
Q7L7X3 |
TAOK1 | Serine/threonine-protein kinase TAO1 | Homo sapiens | 179 | Detail |
O43318 |
MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | Homo sapiens | 178 | Detail |
O15111 |
CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | Homo sapiens | 170 | Detail |
O75582 |
RPS6KA5 | Ribosomal protein S6 kinase alpha-5 | Homo sapiens | 157 | Detail |
P10636 |
MAPT | Microtubule-associated protein tau | Homo sapiens | 150 | Detail |
P01584 |
IL1B | Interleukin-1 beta | Homo sapiens | 148 | Detail |
Q8IVH8 |
MAP4K3 | Mitogen-activated protein kinase kinase kinase kinase 3 | Homo sapiens | 148 | Detail |
Q13936 |
CACNA1C | Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens | 147 | Detail |
P36507 |
MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | Homo sapiens | 146 | Detail |
Q15418 |
RPS6KA1 | Ribosomal protein S6 kinase alpha-1 | Homo sapiens | 144 | Detail |
P37173 |
TGFBR2 | TGF-beta receptor type-2 | Homo sapiens | 144 | Detail |
P01375 |
TNF | Tumor necrosis factor | Homo sapiens | 144 | Detail |
P19838 |
NFKB1 | Nuclear factor NF-kappa-B p105 subunit | Homo sapiens | 140 | Detail |
Q04206 |
RELA | Transcription factor p65 | Homo sapiens | 134 | Detail |
Q00653 |
NFKB2 | Nuclear factor NF-kappa-B p100 subunit | Homo sapiens | 126 | Detail |
P49137 |
MAPKAPK2 | MAP kinase-activated protein kinase 2 | Homo sapiens | 124 | Detail |
P22694 |
PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Homo sapiens | 121 | Detail |
Q9NYL2 |
MAP3K20 | Mitogen-activated protein kinase kinase kinase 20 | Homo sapiens | 117 | Detail |
Q01668 |
CACNA1D | Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens | 117 | Detail |
O60840 |
CACNA1F | Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens | 117 | Detail |
Q13698 |
CACNA1S | Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens | 117 | Detail |
P22612 |
PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | Homo sapiens | 111 | Detail |
P21860 |
ERBB3 | Receptor tyrosine-protein kinase erbB-3 | Homo sapiens | 109 | Detail |
Q15349 |
RPS6KA2 | Ribosomal protein S6 kinase alpha-2 | Homo sapiens | 109 | Detail |
Q13153 |
PAK1 | Serine/threonine-protein kinase PAK 1 | Homo sapiens | 107 | Detail |
Q15750 |
TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | Homo sapiens | 97 | Detail |
Q00975 |
CACNA1B | Voltage-dependent N-type calcium channel subunit alpha-1B | Homo sapiens | 96 | Detail |
Q13043 |
STK4 | Serine/threonine-protein kinase 4 | Homo sapiens | 94 | Detail |
Q02641 |
CACNB1 | Voltage-dependent L-type calcium channel subunit beta-1 | Homo sapiens | 85 | Detail |
Q99683 |
MAP3K5 | Mitogen-activated protein kinase kinase kinase 5 | Homo sapiens | 81 | Detail |
Q16584 |
MAP3K11 | Mitogen-activated protein kinase kinase kinase 11 | Homo sapiens | 79 | Detail |
Q9H2K8 |
TAOK3 | Serine/threonine-protein kinase TAO3 | Homo sapiens | 73 | Detail |
P09038 |
FGF2 | Fibroblast growth factor 2 | Homo sapiens | 69 | Detail |
P05412 |
JUN | Transcription factor Jun | Homo sapiens | 69 | Detail |
P80192 |
MAP3K9 | Mitogen-activated protein kinase kinase kinase 9 | Homo sapiens | 68 | Detail |
Q13163 |
MAP2K5 | Dual specificity mitogen-activated protein kinase kinase 5 | Homo sapiens | 65 | Detail |
Q9NY47 |
CACNA2D2 | Voltage-dependent calcium channel subunit alpha-2/delta-2 | Homo sapiens | 63 | Detail |
Q8WXS5 |
CACNG8 | Voltage-dependent calcium channel gamma-8 subunit | Homo sapiens | 62 | Detail |
Q8IW41 |
MAPKAPK5 | MAP kinase-activated protein kinase 5 | Homo sapiens | 61 | Detail |
O75676 |
RPS6KA4 | Ribosomal protein S6 kinase alpha-4 | Homo sapiens | 60 | Detail |
Q9Y698 |
CACNG2 | Voltage-dependent calcium channel gamma-2 subunit | Homo sapiens | 59 | Detail |
Q8IV61 |
RASGRP3 | Ras guanyl-releasing protein 3 | Homo sapiens | 57 | Detail |
Q9UBE8 |
NLK | Serine/threonine-protein kinase NLK | Homo sapiens | 54 | Detail |
Q12852 |
MAP3K12 | Mitogen-activated protein kinase kinase kinase 12 | Homo sapiens | 54 | Detail |
Q9UK32 |
RPS6KA6 | Ribosomal protein S6 kinase alpha-6 | Homo sapiens | 53 | Detail |
P54284 |
CACNB3 | Voltage-dependent L-type calcium channel subunit beta-3 | Homo sapiens | 49 | Detail |
Q13177 |
PAK2 | Serine/threonine-protein kinase PAK 2 | Homo sapiens | 47 | Detail |
Q13164 |
MAPK7 | Mitogen-activated protein kinase 7 | Homo sapiens | 46 | Detail |
P05230 |
FGF1 | Fibroblast growth factor 1 | Homo sapiens | 45 | Detail |
O00555 |
CACNA1A | Voltage-dependent P/Q-type calcium channel subunit alpha-1A | Homo sapiens | 45 | Detail |
Q08289 |
CACNB2 | Voltage-dependent L-type calcium channel subunit beta-2 | Homo sapiens | 45 | Detail |
Q06432 |
CACNG1 | Voltage-dependent calcium channel gamma-1 subunit | Homo sapiens | 45 | Detail |
O60359 |
CACNG3 | Voltage-dependent calcium channel gamma-3 subunit | Homo sapiens | 44 | Detail |
Q9UF02 |
CACNG5 | Voltage-dependent calcium channel gamma-5 subunit | Homo sapiens | 44 | Detail |
Q9UBN1 |
CACNG4 | Voltage-dependent calcium channel gamma-4 subunit | Homo sapiens | 44 | Detail |
Q8IZS8 |
CACNA2D3 | Voltage-dependent calcium channel subunit alpha-2/delta-3 | Homo sapiens | 44 | Detail |
P62955 |
CACNG7 | Voltage-dependent calcium channel gamma-7 subunit | Homo sapiens | 44 | Detail |
Q9BXT2 |
CACNG6 | Voltage-dependent calcium channel gamma-6 subunit | Homo sapiens | 44 | Detail |
P15692 |
VEGFA | Vascular endothelial growth factor A, long form | Homo sapiens | 44 | Detail |
Q15878 |
CACNA1E | Voltage-dependent R-type calcium channel subunit alpha-1E | Homo sapiens | 44 | Detail |
O00305 |
CACNB4 | Voltage-dependent L-type calcium channel subunit beta-4 | Homo sapiens | 44 | Detail |
Q7Z3S7 |
CACNA2D4 | Voltage-dependent calcium channel subunit alpha-2/delta-4 | Homo sapiens | 44 | Detail |
P51452 |
DUSP3 | Dual specificity protein phosphatase 3 | Homo sapiens | 38 | Detail |
P10398 |
ARAF | Serine/threonine-protein kinase A-Raf | Homo sapiens | 37 | Detail |
Q9Y2U5 |
MAP3K2 | Mitogen-activated protein kinase kinase kinase 2 | Homo sapiens | 36 | Detail |
Q02779 |
MAP3K10 | Mitogen-activated protein kinase kinase kinase 10 | Homo sapiens | 33 | Detail |
P45985 |
MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | Homo sapiens | 31 | Detail |
P48454 |
PPP3CC | Serine/threonine-protein phosphatase 2B catalytic subunit ga | Homo sapiens | 27 | Detail |
Q9UL54 |
TAOK2 | Serine/threonine-protein kinase TAO2 | Homo sapiens | 27 | Detail |
Q99759 |
MAP3K3 | Mitogen-activated protein kinase kinase kinase 3 | Homo sapiens | 26 | Detail |
P01100 |
FOS | Protein c-Fos | Homo sapiens | 25 | Detail |
P35236 |
PTPN7 | Tyrosine-protein phosphatase non-receptor type 7 | Homo sapiens | 24 | Detail |
P01106 |
MYC | Myc proto-oncogene protein | Homo sapiens | 19 | Detail |
P52564 |
MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | Homo sapiens | 17 | Detail |
P01127 |
PDGFB | Platelet-derived growth factor subunit B | Homo sapiens | 16 | Detail |
P60953 |
CDC42 | Cell division control protein 42 homolog | Homo sapiens | 16 | Detail |
P41279 |
MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | Homo sapiens | 15 | Detail |
O14733 |
MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 | Homo sapiens | 15 | Detail |
Q16644 |
MAPKAPK3 | MAP kinase-activated protein kinase 3 | Homo sapiens | 15 | Detail |
P01112 |
HRAS | GTPase HRas | Homo sapiens | 14 | Detail |
P30305 |
CDC25B | M-phase inducer phosphatase 2 | Homo sapiens | 14 | Detail |
O95267 |
RASGRP1 | RAS guanyl-releasing protein 1 | Homo sapiens | 13 | Detail |
Q9Y6K9 |
IKBKG | NF-kappa-B essential modulator | Homo sapiens | 13 | Detail |
P46734 |
MAP2K3 | Dual specificity mitogen-activated protein kinase kinase 3 | Homo sapiens | 12 | Detail |
O95382 |
MAP3K6 | Mitogen-activated protein kinase kinase kinase 6 | Homo sapiens | 11 | Detail |
P47712 |
PLA2G4A | Cytosolic phospholipase A2 | Homo sapiens | 10 | Detail |
P04792 |
HSPB1 | Heat shock protein beta-1 | Homo sapiens | 8 | Detail |
P01137 |
TGFB1 | Transforming growth factor beta-1 proprotein | Homo sapiens | 8 | Detail |
P15514 |
AREG | Amphiregulin | Homo sapiens | 7 | Detail |
Q9Y6R4 |
MAP3K4 | Mitogen-activated protein kinase kinase kinase 4 | Homo sapiens | 7 | Detail |
P53041 |
PPP5C | Serine/threonine-protein phosphatase 5 | Homo sapiens | 7 | Detail |
P0DMV8 |
HSPA1A | Heat shock 70 kDa protein 1A | Homo sapiens | 6 | Detail |
P11142 |
HSPA8 | Heat shock cognate 71 kDa protein | Homo sapiens | 5 | Detail |
P28562 |
DUSP1 | Dual specificity protein phosphatase 1 | Homo sapiens | 4 | Detail |
P62993 |
GRB2 | Growth factor receptor-bound protein 2 | Homo sapiens | 4 | Detail |
P14210 |
HGF | Hepatocyte growth factor | Homo sapiens | 4 | Detail |
P22736 |
NR4A1 | Nuclear receptor subfamily 4immunitygroup A member 1 | Homo sapiens | 4 | Detail |
Q08209 |
PPP3CA | Protein phosphatase 3 catalytic subunit alpha | Homo sapiens | 4 | Detail |
P0C869 |
PLA2G4B | Cytosolic phospholipase A2 beta | Homo sapiens | 3 | Detail |
P49763 |
PGF | Placenta growth factor | Homo sapiens | 3 | Detail |
O75688 |
PPM1B | Protein phosphatase 1B | Homo sapiens | 3 | Detail |
P63000 |
RAC1 | Ras-related C3 botulinum toxin substrate 1 | Homo sapiens | 3 | Detail |
P15153 |
RAC2 | Ras-related C3 botulinum toxin substrate 2 | Homo sapiens | 3 | Detail |
Q16690 |
DUSP5 | Dual specificity protein phosphatase 5 | Homo sapiens | 2 | Detail |
P60763 |
RAC3 | Ras-related C3 botulinum toxin substrate 3 | Homo sapiens | 2 | Detail |
P61812 |
TGFB2 | Transforming growth factor beta-2 proprotein | Homo sapiens | 2 | Detail |
P19438 |
TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A | Homo sapiens | 2 | Detail |
Q9UP65 |
PLA2G4C | Cytosolic phospholipase A2 gamma | Homo sapiens | 2 | Detail |
P08571 |
CD14 | Monocyte differentiation antigen CD14 | Homo sapiens | 2 | Detail |
P46109 |
CRKL | Crk-like protein | Homo sapiens | 1 | Detail |
Q16828 |
DUSP6 | Dual specificity protein phosphatase 6 | Homo sapiens | 1 | Detail |
P21333 |
FLNA | Filamin-A | Homo sapiens | 1 | Detail |
P0DMV9 |
HSPA1B | Heat shock 70 kDa protein 1B | Homo sapiens | 1 | Detail |
P14778 |
IL1R1 | Interleukin-1 receptor type 1 | Homo sapiens | 1 | Detail |
P49407 |
ARRB1 | Beta-arrestin-1 | Homo sapiens | 1 | Detail |
P61244 |
MAX | Protein max | Homo sapiens | 1 | Detail |
P01138 |
NGF | Beta-nerve growth factor | Homo sapiens | 1 | Detail |
P04085 |
PDGFA | Platelet-derived growth factor subunit A | Homo sapiens | 1 | Detail |
P35813 |
PPM1A | Protein phosphatase 1A | Homo sapiens | 1 | Detail |
Q12933 |
TRAF2 | TNF receptor-associated factor 2 | Homo sapiens | 1 | Detail |
Q5TCX8 |
MAP3K21 | Mitogen-activated protein kinase kinase kinase 21 | Homo sapiens | 1 | Detail |
Q9UHA4 |
LAMTOR3 | Ragulator complex protein LAMTOR3 | Homo sapiens | 1 | Detail |